Amelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intake

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dc.contributor.authorErdemli, M.E.
dc.contributor.authorDogan, Z.
dc.contributor.authorÇigremis, Y.
dc.contributor.authorAkgöz, M.
dc.contributor.authorAltinöz, E.
dc.contributor.authorGeçer, M.
dc.contributor.authorTürköz, Y.
dc.date.accessioned2024-09-29T16:16:13Z
dc.date.available2024-09-29T16:16:13Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractAcrylamide (AA) has neurotoxic, mutagenic, and genotoxic effects in humans and experimental animals. Fruit consumption is important for human health, because fruits are the source of many nutrients such as vitamins, minerals, carotenoids, dietary fiber, and phytonutrients. Many agricultural products provide natural melatonin in the diet. At the onset of the study, rats were weighted and randomly divided into four groups each containing 10 rats as follows: group 1: control (fed with normal diet and normal drinking water); group 2: apricot (fed with a daily diet with 5% apricot and normal drinking water); group 3: AA (administered daily acrylamide at 500 ?g/kg b.w. via drinking water and fed a normal diet); group 4: apricot-AA (administered daily acrylamide at 500 ?g/kg b.w. via drinking water and fed with a diet with 5% apricot). The diet schedule was continued for 12 weeks. At the end of the study, samples of large intestine were collected for biochemical analyses. The highest lipid peroxidation (as malondialdehyde, MDA) levels were observed in the AA groups, but MDA levels decreased significantly (P < 0.05) with apricot intake. Glutathione peroxidase activity in the apricot- AA group was higher than in the other three groups (P < 0.05). Glutathione S-transferase (GST) enzyme activity increased significantly in the AA group as compared with the other groups (P < 0.05). However, GST activity was significantly (P < 0.05) decreased by the apricot-supplemented diet. GST-Pi mRNA levels in the AA group increased significantly (P < 0.05) as compared with the other groups. In conclusion, the results of the current study demonstrated that AA caused large intestine damage and showed the efficiency of apricot in preventing this damage by inhibiting lipid peroxidation and improving antioxidant enzyme activities. © TÜBİTAKen_US
dc.identifier.doi10.3906/biy-1505-31
dc.identifier.endpage878en_US
dc.identifier.issn1300-0152
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84946717386en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage872en_US
dc.identifier.urihttps://doi.org/10.3906/biy-1505-31
dc.identifier.urihttps://hdl.handle.net/20.500.14619/8944
dc.identifier.volume39en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScientific and Technical Research Council of Turkeyen_US
dc.relation.ispartofTurkish Journal of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcrylamideen_US
dc.subjectAntioxidant enzymesen_US
dc.subjectApricoten_US
dc.subjectGST-Pien_US
dc.subjectLarge intestineen_US
dc.subjectRaten_US
dc.titleAmelioration of subchronic acrylamide toxicity in large intestine of rats by organic dried apricot intakeen_US
dc.typeArticleen_US

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