The protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorAltinoz, E.
dc.contributor.authorTurkoz, Y.
dc.contributor.authorVardi, N.
dc.date.accessioned2024-09-29T16:08:28Z
dc.date.available2024-09-29T16:08:28Z
dc.date.issued2015
dc.departmentKarabük Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the protective effects of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissues in rats. The rats were divided into four groups. Acrylamide administration increased MDA levels in all tissues significantly (p < 0.05). But acrylamide+NAC administration decreased MDA levels significantly as compared to the acrylamide group, and lowered it to a level close to the control group values (p < 0.05). GSH levels in liver and small intestine tissues reduced significantly in the acrylamide group (p < 0.05). But acrylamide+NAC administration increased GSH levels significantly in all tissues. Whereas GST activity decreased significantly in the acrylamide group in liver and small intestine tissues as compared to the other groups (p < 0.05), the GST activity increased significantly in the acrylamide+NAC group in all tissues as compared to the acrylamide group (p < 0.05). Liver histopathology showed that the liver epithelial cells were damaged significantly in the acrylamide group. Small intestine histopathology showed that the intestinal villous epithelial cells were damaged significantly in the acrylamide group. Our results indicate that a high level of acrylamide causes oxidative damage in liver and small and large intestine tissues, while N-acetylcysteine administration in a pharmacological dose shows to have an antioxidant effect in preventing this damage (Tab. 2, Fig. 2, Ref. 66). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2015_049
dc.identifier.endpage258en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue4en_US
dc.identifier.pmid25773954en_US
dc.identifier.scopus2-s2.0-84928521784en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage252en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_049
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7571
dc.identifier.volume116en_US
dc.identifier.wosWOS:000351975100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectacrylamideen_US
dc.subjectN-acetylcysteineen_US
dc.subjectoxidative stressen_US
dc.subjectliveren_US
dc.subjectsmall and large intestineen_US
dc.titleThe protective effect of N-acetylcysteine against acrylamide toxicity in liver and small and large intestine tissuesen_US
dc.typeArticleen_US

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