Neuroprotection against CCl4 induced brain damage with crocin in Wistar rats

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorAltinoz, E.
dc.contributor.authorErdemli, M. E.
dc.contributor.authorGul, M.
dc.contributor.authorAksungur, Z.
dc.contributor.authorGul, S.
dc.contributor.authorBag, H. G.
dc.contributor.authorKaya, G. B.
dc.date.accessioned2024-09-29T16:02:51Z
dc.date.available2024-09-29T16:02:51Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractOwing to its lipophilic property, carbon tetrachloride (CCl4) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl4. Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl4 and CCl4 + crocin. CCl4 administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl4 treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture. We found that crocin administration nearly eliminated CCl4 induced brain damage by preventing oxidative stress.en_US
dc.identifier.doi10.1080/10520295.2018.1519725
dc.identifier.endpage631en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue8en_US
dc.identifier.pmid30273072en_US
dc.identifier.scopus2-s2.0-85054386999en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage623en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2018.1519725
dc.identifier.urihttps://hdl.handle.net/20.500.14619/5733
dc.identifier.volume93en_US
dc.identifier.wosWOS:000451027400011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain damageen_US
dc.subjectcarbon tetrachlorideen_US
dc.subjectcatalaseen_US
dc.subjectcrocinen_US
dc.subjectglutathioneen_US
dc.subjectmalondialdehydeen_US
dc.subjectoxidative stressen_US
dc.titleNeuroprotection against CCl4 induced brain damage with crocin in Wistar ratsen_US
dc.typeArticleen_US

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