Effect of Luteolin on Biochemical, Immunohistochemical, and Morphometrical Changes in Rat Spinal Cord following Exposure to a 900 MHz Electromagnetic Field
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Chinese Center Disease Control & Prevention
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective This study aimed to investigate the effect of exposure to a 900 MHz electromagnetic field (EMF) on the cervical spinal cord (CSC) of rats and the possible protective effect of luteolin (LUT) against CSC tissue damage. Methods Quantitative data were obtained via stereological, biochemical, immunohistochemical, and histopathological techniques. We investigated morphometric value, superoxide dismutase (SOD) level, and the expression of high-mobility group box 1 protein molecules, as well as histological changes. Results The total number of motor neurons in the EMF group significantly decreased in comparison with that in the control group (P < 0.05). In the EMF + LUT group, we found a significant increase in the total number of motor neurons compared with that in the EMF group (P < 0.05). SOD enzyme activity in the EMF group significantly increased in comparison with that in the control group (P < 0.05). By contrast, the EMF+LUT group exhibited a decrease in SOD level compared with the EMF group (P < 0.05). Conclusion Our results suggested that exposure to EMF could be deleterious to CSC tissues. Furthermore, the protective efficacy of LUT against SC damage might have resulted from the alleviation of oxidative stress caused by EMF.
Açıklama
Anahtar Kelimeler
Electromagnetic field, Luteolin, Motor neuron, Oxidative stress, Rat, Spinal cord
Kaynak
Biomedical and Environmental Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
33
Sayı
8
