Investigation of the effects of acrylamide applied during pregnancy on fetal brain development in rats and protective role of the vitamin E

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dc.authoridAltinoz, Eyup/0000-0002-3991-9773
dc.contributor.authorErdemli, M. E.
dc.contributor.authorTurkoz, Y.
dc.contributor.authorAltinoz, E.
dc.contributor.authorElibol, E.
dc.contributor.authorDogan, Z.
dc.date.accessioned2024-09-29T16:05:02Z
dc.date.available2024-09-29T16:05:02Z
dc.date.issued2016
dc.departmentKarabük Üniversitesien_US
dc.description.abstractA liberal amount of acrylamide (AA) is produced as a result of frying or baking foods in high temperatures, and individuals take certain amounts of AA everyday by consuming these food items. Pregnant women are also exposed to AA originating from food during pregnancy and their fetus are probably affected. The rats were divided into five different groups: control (C), corn oil (CO), vitamin E (Vit E), AA, and Vit E + AA, with eight pregnant rats in each group. On the 20th day of pregnancy, fetuses were removed and brain tissues of fetuses were examined for biochemical and histological changes. AA caused degeneration in neuron structures in fetal brain tissue and caused hemorrhagic damages; dramatically decreased brain-derived neurotrophic factor levels; increased malondialdehyde, total oxidant capacity levels; and decreased reduced glutathione and total antioxidant capacity levels (p < 0.05). On the other hand, it was determined that the Vit E, a neuroprotectant and a powerful antioxidant, suppressed the effects of AA on fetal development and fetal brain tissue damage for the above-mentioned parameters (p < 0.05). It is recommended to consume food containing Vit E as a protection to minimize the toxic effects of food-oriented AA on fetus development due to the widespread nature of fast-food culture in today's life and the impossibility of protection from AA toxicity.en_US
dc.description.sponsorshipScientific Research Fund of Inonu University [INU-BAP 2015/92]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by a grant from the Scientific Research Fund of Inonu University (Grant number: INU-BAP 2015/92).en_US
dc.identifier.doi10.1177/0960327116632049
dc.identifier.endpage1344en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue12en_US
dc.identifier.pmid26916244en_US
dc.identifier.scopus2-s2.0-84994619223en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1337en_US
dc.identifier.urihttps://doi.org/10.1177/0960327116632049
dc.identifier.urihttps://hdl.handle.net/20.500.14619/6476
dc.identifier.volume35en_US
dc.identifier.wosWOS:000387361200010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectvitamin Een_US
dc.subjectpregnancyen_US
dc.subjectbrain-derived neurotrophic factor (BDNF)en_US
dc.subjectoxidative stressen_US
dc.titleInvestigation of the effects of acrylamide applied during pregnancy on fetal brain development in rats and protective role of the vitamin Een_US
dc.typeArticleen_US

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