Does the type of nephrectomy affect oncologic outcomes in pathological stage ptt1 renal cell carcinoma with high fuhrman grade?
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
INTRODUCTION: In clinical stage I renal cell carcinoma (RCC), partial nephrectomy (PN) is actualrecommended surgical technique. However, poor pathological tumor features have more negative prognosis. Weaimed to evaluate the effects of performing partial or radical nephrectomy(RN) on local recurrence, distantmetastasis and cancer-specific survival in stage pT1 RCC with high Fuhrman grade.METHODS: Data of patients who underwent PN or RN due to pathological stage pT1 RCC with high Fuhrmangrade, between January 2009 and July 2016 were retrospectively evaluated. 66 of them whose datas were fullyaccessible, were included to study. Demographic datas, histological tumor types, Fuhrman grading, local recurrence, distant metastasis and survival rates after nephrectomy were recorded. The patients were divided intotwo groups as RN (Group I) and PN (Group II).RESULTS: Mean age of patients was 57.67±10.23. Among them, 6(9.1%) patients had local recurrence,8(12.1%) had distant metastasis and 8(12.1%) had cancer related death. Group II had higher local recurrence rate(11.1%, p=0.532), distant metastasis rate (18.9%, p=0.630), cancer-specific survival (94.16 months, p=0.560);lower predicted recurrence-free survival (89.46 months, p=0.433) and metastasis-free survival (84.94 months,p=0.617). But there were no significantly difference. In multivariate analysis, hypertension for local recurrence;Fuhrman grade 4, female gender, BMI>27 for distant metastasis, and estimated glomerular filtration rate<90 forcancer-specific survival were independent predictive factors.DISCUSSION and CONCLUSION: We found that PN or RN did not significantly alter the oncologicoutcomes in follow-up of patients with high Fuhrman grade, stage pT1 RCC. For this reason, it is moreappropriate to use nephron sparing technique.
Açıklama
Anahtar Kelimeler
Tıbbi İnformatik, Genel ve Dahili Tıp, Temel Sağlık Hizmetleri, Onkoloji, Sağlık Bilimleri ve Hizmetleri
Kaynak
ACTA ONCOLOGICA TURCICA
WoS Q Değeri
Scopus Q Değeri
Cilt
51
Sayı
3
