Comparative evaluation of the trabecular structure of the mandibular condyle, the levels of salivary cortisol, MMP-3, TNF-a, IL-1,6 in individuals with and without temporomandibular joint disorder
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Temporomandibular disorder (TMD) is still a challenge in terms of diagnosis and management. The aim of this study is to explore if the evaluation of salivary biomarkers and fractal dimension (FD) of mandibu-lar condyle could be useful for interpreting early degenerative changes and the effectiveness of salivary corti-sol in determining the stress levels of TMD patients.Materials and Methods: 34 patients with TMD, and 34 healthy controls were included in this study. Saliva samples were obtained from all participants between 09:00-12:00 am. Salivary cortisol, IL-1,6, TNF-a, and MMP-3 levels were evaluated with ELISA method. FD of the mandibular condyle was determined by means of box-counting method. Depression and anxiety were determined with PHQ-9 and GAD-7 questionnaires.Results: The salivary cortisol and depression/anxiety were higher in study group; however, not significant (p>0.05). FD of the study group was found significantly lower than the control group (p<0.01). Salivary TNF-a, IL-1,6 and MMP-3 levels were showed no significant difference between the two groups (p>0.05). There were no significant correlations between the evaluated parameters.Conclusion: Salivary cortisol seems to be a non-invasive way of measuring physiological stress of TMD patients. Fractal analysis may be a useful tool in detecting early structural changes in mandibular condyle. Salivary TNF-a. IL-1,6 and MMP-3 have not a diagnostic value in terms of interpreting early degenerative changes.(c) 2023 Elsevier Masson SAS. All rights reserved.
Açıklama
Anahtar Kelimeler
Biomarker, Fractal analysis, Mandibular condyle, Microstructure of bone Saliva, Temporomandibular disorders
Kaynak
Journal of Stomatology Oral and Maxillofacial Surgery
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
124
Sayı
4
