Ataseyer-Arslan, BelkisYilancioglu, KaanBekaroglu, Maide G.Taskin, EmreAltinoz, EyupCetiner, Selim2024-09-292024-09-2920150231-58821338-4325https://doi.org/10.4149/gpb_2014034https://hdl.handle.net/20.500.14619/7576Cytotoxic effects of essential oils extracted from Dunaliella sauna on SH-SY5Y human neuroblastoma cells were investigated in this study. GC-MS analysis was used for determination of the composition of essential oils found in Dunaliella salina extract. All experimented concentrations of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells were significantly more cytotoxic than the tested concentrations of the extract on ECV304 human endothelial cells used as a control. Fifthy compounds were detected in GC-MS analysis of the extract, and five major compounds were predominantly found as follows: octadecanoic acid, methyl ester (27.43%); hexadecanoic acid, methyl ester (Cas) methyl palmitate (24.82%); 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (7.39%); octadecanoic acid (5.03%), pentadecanoic acid (3.60%). The cytotoxic activity of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells might be due to high concentrations of octadecanoic acid and hexadecanoic acid. Furthermore, results indicate that the extract demonstrates some proliferative effect on ECV304 cells in a dose-dependent manner between 0.25 and 5 mu g/ml. These results suggest that Dunaliella sauna may have anticancer potential against human neuroblastoma cells.eninfo:eu-repo/semantics/openAccessAlgaeCytotoxicityDunaliella salinaEssential oilSH-SY5Y human neuroblastoma cellsArticle10.4149/gpb_201403420722567538820134WOS:000353181500010Q4