Motameni, AliDalgic, Ali DenizAlshemary, Ammar Z.Keskin, DilekEvis, Zafer2024-09-292024-09-2920202352-4928https://doi.org/10.1016/j.mtcomm.2020.101151https://hdl.handle.net/20.500.14619/5162In this study, mesoporous particles of beta-tricalcium phosphate (beta TCP, beta Ca-3(PO4)(2)) and lanthanum (La) doped beta TCP were synthesized using wet precipitation method attached with microwave refluxing system. The obtained materials were characterized and analysed using different sort of techniques such; X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Inductively coupled plasma optical emission spectroscopy (ICP-OES), Brunauer-Emmett-Teller (BET) and helium pycnometer. With incorporation of La3+ ions, relevant expansion in lattice parameters of beta TCP crystal was observed along with inhibition growth rate was observed. beta TCP and La-beta TCP materials were mesoporous in nature, pore diameter and pore volume were expanded with incorporation of La3+ ions. The loading/release on beta TCP and La-beta TCP particles surfaces were evaluated using fetal bovine serum (FBS) proteins. In vitro cell culture studies were performed with human osteosarcoma cell line (Saos-2). The outcomes approved that all La-beta TCP materials were cytocompatible and strict dose dependent effect of La3+ ions was observed on cell viability and alkaline phosphatase (ALP) activity. These results strongly suggest that La-beta TCP materials have a potential application in bone tissue engineering.eninfo:eu-repo/semantics/closedAccessbeta-Tricalcium phosphateLanthanumMesoporous particlesIn vitro degradationBone graft materialsArticle10.1016/j.mtcomm.2020.1011512-s2.0-85083590584Q223WOS:000536945200002Q2