Tumer, YaseminAsmafiliz, NuranKilic, ZeynelAydin, BetulAcik, LeylaHokelek, Tuncer2024-09-292024-09-2920180022-28601872-8014https://doi.org/10.1016/j.molstruc.2018.07.050https://hdl.handle.net/20.500.14619/5129The cis- (5 and 6) and trans-dispiroferrocenylphosphazenes (7 and 8) containing ferrocenyl pendant arms were synthesized from the reactions of hexachlorocyclotriphosphazene, N3P3Cl6, with two equimolar amounts of the sodium salts of the ligands; [2-(N-ferrocenylmethylamino)-1-ethanoxide (1) and 3-(N-ferrocenylmethylamino)-1-propanoxide (2)]. The monospiroferrocenylcyclotriphosphazenes (3 and 4) were also isolated from the reaction mixtures as by-products. The characterizations of the new compounds (5-8) were elucidated using MS, FTIR and H-1, C-13 and P-31 NMR techniques. The molecular structure of 6 was established by X-ray crystallography. As expected, compounds 5, 6, 7 and 8 have two stereogenic P-atoms. The compounds 5 and 6 are likely to be in cis (meso) forms, whereas the compounds 7 and 8 are in trans (racemic) forms. Besides, the antimicrobial activities of the cyclotriphosphazenes against G(+) and G(-) bacteria and fungi were evaluated. The interactions of the compounds with pBR322 plasmid DNA were also investigated. (C) 2018 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessDispiroferrocenylphosphazenesSpectroscopyChiral phosphazenesAntimicrobial activityCrystal structureArticle10.1016/j.molstruc.2018.07.0502-s2.0-85050486217893Q28851173WOS:000446286200096Q3