Deniz, Muzaffer SerdarKaraahmetoglu, Selma2024-09-292024-09-292023https://doi.org/10.14744/ejmi.2023.93800https://search.trdizin.gov.tr/tr/yayin/detay/1184766https://hdl.handle.net/20.500.14619/10249Objectives: The study aimed to investigate the patients with isolated iron deficiency (IID) and chronic disease-ac- companied iron deficiency (CDID) and to analyze the predictive values of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) that can help us to distinguish IID from CDID. Methods: Three hundred patients joined the present cross-sectional thesis study. Half had chronic diseases+ID (with- out anemia) called as CDID, while the other half did not have any chronic disease or anemia called IID in the text. Labo- ratory parameters and patient histories were obtained from the automation system and analyzed. Results: The CDID was associated with ferritin increase (Odds Ratio [OR]=1.123; 95% Confidence Intervals [CI]=1.084– 1.165). Increased sedimentation was associated with an increased risk of having a CDID (OR=1.023; 95% CI = 1.003– 1.045). Ferritin showed a predictive potential for CDID with 67.2% specificity and 71.1% sensitivity at a 12.1 cutoff value (Auc:0.781; p<0.0001). NLR was the second strong predictor of CDID against IID, with 64.1% specificity and 63.5% sensitivity at a 2.09 cutoff (Auc:0.629; p<0.0001). PLR had no significance for discrimination of CDID and IID. Conclusion: NLR can provide diagnostic support like ferritin in predicting CDID against IID and benefit physicians in the clinical use of differentiation, unlike PLR.eninfo:eu-repo/semantics/openAccessArticle10.14744/ejmi.2023.93800145214111847667