Akkiz, HikmetTaskin, EmreKaraogullarindan, UmitDelik, AnilKuran, SedefKutlu, Ozlem2024-09-292024-09-2920210025-79741536-5964https://doi.org/10.1097/MD.0000000000025893https://hdl.handle.net/20.500.14619/5942We aimed to elucidate the frequency of polymorphic genotypes and alleles of patatin-like phospholipase domain containing 3 rs738409 polymorphism and its possible associations with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis in a cohort from Turkey. We enrolled 200 patients diagnosed with NAFLD and genotyped for rs738409 I148M polymorphism by real-time polymerase chain reaction, particularly by melting curve analysis. SPSS analysis software was used for statistical significance. Continuous variable values were expressed as mean +/- standard deviation. Significant statistical level was chosen as p = 0.05. Our results demonstrate in a cohort from Turkey that rs738409 C > G polymorphism (I148M) of patatin-like phospholipase domain containing 3 gene is significantly able to affect individuals to have NAFLD in unadjusted regression model. Consistent with the previous studies in other populations, our study group showed a significantly higher risk of having NAFLD in unadjusted regression model but not in the adjusted model indicating that non-genetic factors such as age and sex may be responsible for the association. However, independent studies need to validate our findings with a larger group of NAFLD patients, as well as in different ethnic cohorts.eninfo:eu-repo/semantics/openAccessNAFLDNASHPNPLA3rs738409Turkish patientsArticle10.1097/MD.00000000000258932-s2.0-851079604421934106646Q3100WOS:000658910800066Q3