Arikan, MugeAslan, BilgeArikan, OsmanHorasanli, EyupBut, Abdulkadir2024-09-292024-09-2920160102-86501678-2674https://doi.org/10.1590/S0102-865020160010000010https://hdl.handle.net/20.500.14619/6815PURPOSE: To compare the effects of magnesium sulfate and ketamine on postoperative pain and total morphine consumption in a placebo-controlled design. METHODS: One hundred and twenty women scheduled for total abdominal hysterectomy were included in this prospective, randomized, double-blind study. Postoperatively, when the Numeric Pain Rating Scale (NPRS) was four or more, IV-PCA morphine was applied to all patients. The patients were randomized into three groups: Group K ketamine, Group M magnesium, and Group C saline received as infusion. Total morphine consumption for 48h, pain scores, adverse effects, and patients' satisfaction were evaluated. RESULTS: Total morphine consumption was significantly lower in Group K (32.6 +/- 9.2 mg) than in Group M (58.9 +/- 6.5 mg) and in Group C (65.7 +/- 8.2 mg). The satisfaction level of patients in Group K was higher than the other two groups (p<0.05). Pruritus and nausea were observed more frequently in Group C. CONCLUSION: The addition of ketamine to IV-PCA morphine reduces the total consumption of morphine without psychotic effects; however, magnesium did not influence morphine consumption.eninfo:eu-repo/semantics/openAccessAnalgesia, Patient-ControlledMorphineMagnesium SulfateKetamineArticle10.1590/S0102-8650201600100000102-s2.0-8495691009773126840358Q36731WOS:000369657900010Q4