Bulbul, MehmetTekce, AliAnnac, EbruKorkmaz, OmerOnderci, MuhittinKorkmaz, DenizDemirci, Akin Mustafa2024-09-292024-09-2920232233-82332233-8241https://doi.org/10.5653/cerm.2022.05596https://hdl.handle.net/20.500.14619/7866Objective: The aim of this study was to investigate the effect of royal jelly (RJ), a powerful natural antioxidant, on cyclophosphamide-induced ovarian damage.Methods: Thirty-two Wistar albino rats were divided into four groups. Oral treatment was administered to all rats for 16 days after a single intraperitoneal injection. The control group received intraperitoneal and oral saline; the RJ group received intraperitoneal saline and 100 mg/ kg/day oral RJ; the cyclophosphamide group received intraperitoneal 100 mg/kg cyclophosphamide and oral saline; and the treatment group received intraperitoneal 100 mg/kg cyclophosphamide and 100 mg/kg/day oral RJ. The groups were compared in terms of ovarian reserve tests and histopathological changes in the ovary and uterus.Results: All follicle counts were higher in the treatment group than in the cyclophosphamide group. The increase in the number of preantral follicles (p=0.001) and the decrease in the number of atretic follicles (p=0.004) were statistically significant. RJ treatment significantly improved follicular degeneration and cortical fibrosis in the ovary and epithelial and gland degeneration in the uterus due to cyclophosphamide toxicity.Conclusion: According to these results, RJ reduces cyclophosphamide-related ovarian and endometrial damage in rats. For this reason, it should be further investigated to determine its effects on reproductive function.eninfo:eu-repo/semantics/openAccessCyclophosphamideOvarian follicleOvarian reserveRoyal jellyArticle10.5653/cerm.2022.055962-s2.0-8515081034943136935410Q33450WOS:000941567700005Q3