Altinoz, EyupTaskin, EmreOner, ZulalElbe, HulyaArslan, Belkis Atasever2024-09-292024-09-2920150189-6016https://doi.org/10.4314/ajtcam.v12i5.1https://hdl.handle.net/20.500.14619/7622Background: Diabetes mellitus (DM) causes serious complications such as coronary heart disease, atherosclerosis, nephropathy, retinopathy and neuropathy. Materials and Methods: Rats were randomly divided into three groups, each containing 10 rats: control group, DM group; DM+crocin group. Normal saline was administered in the control and DM groups, and crocin was administered in DM+crocin group at a dose of 20 mg/kg bw/day for 21 days. Trunk blood and the hearth tissue were collected for histopathological and biochemical examination. Results: DM led to increment of MDA levels (p<0.05) and the serum levels of total cholesterol, TG, LDL and VLDL (p<0.05) and decrease of GSH levels (p<0.01) compared to control group in serum and heart tissue. Diabetic rats were treated with crocin, MDA levels (p<0.05) and the levels of total cholesterol, TG and VLDL decreased significantly, but GSH levels (p<0.05) increased remarkably compared to DM rats. Statistically significant increase in histopathological damage score was found in the DM group (p<0.0001). Histopathological changes markedly regressed in DM+crocin group. Conclusion: Our results showed that crocin might prevent diabetes induced cardiovascular complications by reduction of oxidative stress and dyslipidemia.eninfo:eu-repo/semantics/openAccessOxidative stressMDAGSHcrocinDiabetesdislipidemiaArticle10.4314/ajtcam.v12i5.12-s2.0-8496514642975N/A112WOS:000372327600001Q4