Yilmaz, NesibeDeniz, Omur GulsumSecgin, SeydaSecgin, YusufBozduman, Ferhat2025-03-042025-03-042024-05-13Yılmaz, N., Deniz, O. G., Secgin, S., Secgin, Y., & Bozduman, F. (2024). An investigation of the effectiveness of atmospheric pressure cold plasma on sciatic nerve injury in rats. Folia morphologica, 83(4), 813–822. https://doi.org/10.5603/fm.1000190015-5659https://doi.org/10.5603/fm.100019https://hdl.handle.net/20.500.14619/15109Background: The aim of this study was to evaluate the efficacy of atmospheric pressure cold plasma jet and plasma activated medium (PAM) on sciatic nerve injury (SNI). Materials and methods: Rats were divided into 6 groups (n = 10); group 1 (sham), group 2 (SNI), group 3 (SNI + atmospheric pressure cold plasma jet 5 min), group 4 (SNI + atmospheric pressure cold plasma jet 10 min), group 5 (SNI + PAM 5 min), and group 6 (SNI + PAM 10 min). On days 1, 8, 15, and 22 of the study, atmospheric pressure cold plasma jet was applied to rats in groups 3 and 4, and PAM was applied to rats in groups 5 and 6. A hot plate test was applied to all rats on the same days. On day 28, the experiment was terminated, and sciatic nerve tissues were removed for histopathological evaluation. Results: According to the 4-week average of the hot plate tests, a significant relationship was found between group 2 and group 4 and group 6 (p < 0.05). When evaluated within each week, significant differences were found between group 2 and group 4 in week 1, between group 2 and group 5 and group 6 in week 2, between group 2 and group 4 in week 3, and between group 2 and group 4 and group 6 in week 4 (p < 0.05). As a result of histopathological analysis, except for the control group, the other groups had similar characteristics in terms of axonal degeneration, periaxonal swelling, and axon density. Conclusions: As a result of our study, we found that plasma application showed an improvement in the duration of the hot plate test but did not show any improvement histopathologically.eninfo:eu-repo/semantics/openAccessatmospheric pressure cold plasma jethistopathologyhot plate testplasma-activated mediasciatic injuryArticle10.5603/fm.1000192-s2.0-85213831480822438757499Q281383