Eroglu, SemraHaskul, IsmailAziz, VusaleYurtcu, EnginKaratas, FatihNeselioglu, SalimErel, Ozcan2024-09-292024-09-2920170301-21151872-7654https://doi.org/10.1016/j.ejogrb.2017.06.045https://hdl.handle.net/20.500.14619/4574Background: The aim of this study is to measure and compare the dynamic thiol and disulphide homeostasis between patients with Uterine Myoma (UM) and healthy subjects. Material and method: A total of 54 patients with UM who were diagnosed by transvaginal ultrasonography and 37 age-and body mass index-matched healthy individuals were included in this study. Thiol/disulphide homeostasis was measured by a novel automatic spectrophotometric method. Results: The mean serum native thiol, disulphide, and thiol levels were statistically lower in UM group than those in the control group [(284.66 +/- 59.41 mu mol/L vs. 320.98 +/- 56.17 mu mol/L, P < 0.0001), (17.27 +/- 5.59 mu mol/L vs. 22.38 +/- 6.93 mu mol/L P < 0.0001) and (319.21 +/- 61.69 vs. 365.76 +/- 61.46 mu mol/L, P < 0.0001), respectively]. There were no statistically significant differences in ratios of the disulphide/native thiol: native thiol/total thiol, and disulphide/total thiol among patients with UM versus healthy control group (P = 0.096, 0.092, 0.092, respectively). Conclusion: It was found that the native thiol, total thiol, and disulphide levels in patients with UM decreased while the ratio of native thiol/disulphide remained unchanged. It is necessary to investigate whether these findings have a role in the etiology and clinical course of the UM. (C) 2017 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessSerumThiolDisulphideRatioUterine myomaArticle10.1016/j.ejogrb.2017.06.0452-s2.0-850219293042628697394N/A24216WOS:000411771700004Q3