Bicer, M.Akil, M.Avunduk, M.C.Kilic, M.Mogulkoc, R.Baltaci, A.K.2024-09-292024-09-2920110423-104Xhttps://hdl.handle.net/20.500.14619/9934Background: This study aimed to examine the effects of melatonin supplementation on liver glycogen levels in rats with streptozotocin-induced diabetes and subjected to acute swimming exercise. Material and methods: Eighty Sprague-Dawley type adult male rats were divided into eight groups: Group 1, general control; Group 2, melatonin-supplemented control; Group 3, melatonin-supplemented diabetes; Group 4, swimming control; Group 5, melatonin-supplemented swimming; Group 6, melatonin-supplemented diabetic swimming; Group 7, diabetic swimming; Group 8, diabetic control. Melatonin was supplemented at a dose of 3 mg/kg/day intraperitoneally for four weeks. Liver tissue samples were collected and evaluated using a Nikon Eclipse E400 light microscope. All images obtained from the light microscope were transferred to PC medium and evaluated using Clemex PE 3.5 image analysis software. Results: The lowest liver glycogen levels in the study were found in group 4. Liver glycogen levels in groups 3, 6, 7 and 8 (the diabetic groups) were higher than group 4, but lower than those in groups 1 and 2. The lowest liver glycogen levels were obtained in groups 1 and 2. Conclusions: The study indicates that melatonin supplementation maintains the liver glycogen levels that decrease in acute swimming exercise, while induced diabetes prevents this maintenance effect in rats.eninfo:eu-repo/semantics/closedAccessAcute swimming exerciseDiabetesGlycogenMelatoninArticle2-s2.0-79960822229255321717409Q325262