Arslantas, AliAgirtas, Mehmet Salih2024-09-292024-09-2920181300-0527https://doi.org/10.3906/kim-1805-18https://search.trdizin.gov.tr/tr/yayin/detay/381733https://hdl.handle.net/20.500.14619/7501In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide was synthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of the zinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorption spectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurements in a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymus DNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study was also carried out to verify the interaction of CT-DNA with the PcZn complex. The results demonstrated that the octakis phenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative binding mode.eninfo:eu-repo/semantics/openAccessDNA bindingabsorption spectroscopygel electrophoresisthermal meltingphthalocyanine compoundArticle10.3906/kim-1805-182-s2.0-8505490494213205Q3131038173342WOS:000451313100010Q3