Microvawe assisted synthesis of N-(methyl and methoxy) benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition properties

Celik, HulyaKuzu, Muslum2024-09-292024-09-2920191307-6175https://doi.org/10.25135/acg.oc.66.19.07.1327https://hdl.handle.net/20.500.14619/7148In this study, some Schiff base derivatives (6a-f) were synthesized using a microwave method. The synthesized compounds were characterized by 1D, 2D NMR and mass spectral data. Their inhibitory effects were studied on carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulfanilamide affinity chromatography and the compounds N-3-Methylbenzylidene-4-fluoroaniline (6b), N-4-Methylbenzylidene-4-fluoroaniline (6c), N-2-Methoxybenzylidene-4-fluoroaniline (6d) showed moderate activity on hCAII in the range of IC50 values.eninfo:eu-repo/semantics/openAccessSchiff basecarbonic anhydrasemicrobialN-benzylideneanilineMicrovawe assisted synthesis of N-(methyl and methoxy) benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition propertiesArticle10.25135/acg.oc.66.19.07.13272-s2.0-850788474442164Q421012WOS:000504859200004N/A