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Öğe Aortic stiffness increases in proportion to the severity of apnoea–hypopnea index in patients with obstructive sleep apnoea syndrome(Blackwell Publishing Ltd, 2016) Çörtük, M.; Akyol, S.; Baykan, A.O.; Kiraz, K.; Uçar, H.; Çayli, M.; Kandis, H.Background and Aims: Obstructive sleep apnoea syndrome (OSA) and aortic stiffness are associated with an increased risk of cardiovascular morbidity and mortality. Although aortic stiffness increased in patients with OSA, the relationship between severity of OSA indicated with apnoea–hypopnea index (AHI) and aortic stiffness was not investigated in previous studies. The aim of this study is to investigate the relationship between the severity of OSA and aortic stiffness. Methods: In the present study, 90 consecutive OSA patients definite diagnosed with sleep test were prospectively included (mean age 54.5 ± 11.6 years). Aortic pulse wave velocity (PWV) and augmentation index (AIx) were calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm. Aortic distensibility (AD) was calculated from the echocardiographically derived ascending aorta diameters and haemodynamic pressure measurements. Overnight full-laboratory polysomnography examination was conducted on each subject. Patients were classified into two groups according to their median AHI values (AHIlow and AHIhigh groups). Results: PWV values were higher and AD values were lower in AHIhigh group compared with AHIlow group (P < 0.05, for all). AHI was associated with body mass index (BMI), systolic blood pressure, pulse pressure, aortic diameter, AD, AIx and PWV in bivariate analysis (P < 0.05, for all). Multivariate linear regression analysis showed that AHI was independently associated with BMI (? = 0.175, P = 0.047), PWV (? = 0.521, P < 0.001) and aortic distensibility (? = ?0.223, P = 0.020). Conclusions: Aortic stiffness is associated both with the presence and the severity of OSA. © 2014 John Wiley & Sons LtdÖğe Results of bronchoscopic excision in typical carcinoid tumors of the lung in Turkey(Medical Association of Zenica-Doboj Canton, 2017) Boyaci, H.; Çörtük, M.; Gül, S.; Tanriverdi, E.; Özgül, M.A.; Dinçer, H.E.; Çetinkaya, E.Aim Carcinoid tumors of the lung are the tumors originating from the neuroendocrine cells. Surgical excision remains the gold standard for the treatment. Treatment with interventional bronchoscopic excision has also been reported as an alternative option in typical carcinoid tumors of the lung. The aim of this study was to present results and outcomes in patients who were bronchoscopically treated and followed-up. Methods Data of 14 patients, who had undergone bronchoscopic excision due to typical carcinoid tumor of the lung between April 2008 and July 2015 were retrospectively evaluated. Bronchoscopic excision procedures were performed under general anesthesia, while control bronchoscopies were carried out with flexible bronchoscopy. Time between the first and last bronchoscopies was accepted as the follow-up duration. Results A total of 14 patients was evaluated with eight (57.1%) males. Mean age was 43.57±14.07 (23-68) years. The most common symptoms were shortness of breath and coughing. Mean of 5.69±3.35 (2-12) bronchoscopy procedures were performed in the patients during the diagnosis, treatment and follow-up. Mean follow-up duration was 32.0±19.22 months. At the long-term follow-up, two patients developed 50% stenosis and one patient developed granulation tissue in the endobronchial treatment site. None of the patients developed recurrence during the mean 32-month follow-up. Conclusion Endobronchial treatment is a safe and successful treatment method in well selected typical carcinoid tumor cases that are centrally located, having no radiological suspicion of local or distant metastasis, distally visible but not located on the bronchi with a wide base on bronchoscopy. © 2017, Medical Association of Zenica-Doboj Canton. All rights reserved.
