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Öğe Adli yaş tahminine yönelik web of science veritabanında yer alan araştırma çalışmaların bibliometrik analizi(2023) Öcal, Zeynep Ayvat; Bakıcı, Rukiye Sümeyye; Meral, Orhan; Öner, Zülal; Öner, SerkanAmaç: Günümüzde yaş tahmini, biyolojik profil oluşturulmasında yararlanılan, adli bilimlerde kimliklendirme amacıyla sıklıkla kullanılan ve önemli veriler sunan bir yöntemdir. Bu çalışmanın amacı, ISI Web of Knowledge- Science veritabanında yer alan yaş tahmini konusundaki eserlerin bibliometrik analizini yaparak, disiplinler arası etkileşim ve araştırma trendlerini belirlemeye yönelik öneriler sunmaktır. Materyal ve metod: WoS veritabanında yer alan eserler arasından başlığında "age" sözcüğü ve bunun yanı sıra “estimation”, “determination”, “prediction” veya “assessment” sözcüklerinden herhangi birini içeren ma- kaleler tespit edilmiştir. Veritabanının filtreleme özelliğinden yararlanılarak bu makalelerin yazım dili, yayın yılı, yayınlandığı dergi, makalenin yazarları, yazar kurumları, çalışmaların yapıldığı ülke ve makalelere yapılan atıf sayısı ile çalışmaların finansal destek alıp almadığı araştırıldı. Bulgular: -Çalışmamız kapsamını oluşturan 1020 makalenin, (n=990,%97.1) kadarının İngilizce olarak yayın- landığı, eserlerin yayınlandığı günden bugüne toplam 23704 atıf aldığı, incelenen makalelerin (n=993,%97.4) kadarının SCI-E kapsamında indekslenen dergilerde yer aldığı ve en çok çalışmanın (n=145, %10.4) makale ile Almanya’da yapıldığı bilgisine ulaşıldı. Sonuç: Çalışma verileri, WoS veritabanında yer alan makalelerin analiz edilmesi sonucu elde edilen veriler ışığında ülkeler, kurumlar ve araştırmacıların adli yaş tahmini konusundaki bibliometrik analizini ortaya koy- maktadır. Sunulan çalışma, bu alanda yapılan ilk çalışma niteliğindedir. Elde edilen bilgiler araştırmacılar, aka- demisyenler ve diğer paydaşlar için değerli bir kaynak olabilir ve gelecekteki yaş tahmini araştırmalarının yön- lendirilmesine katkı sağlayabilir. Background: Nowadays, age estimation is a method that is utilized in biological profiling, frequently used in forensic sciences for identification purposes and provides important data. The aim of this study is to conduct a bibliometric analysis of the works on age estimation in the ISI Web of Science (WoS) database and to provide suggestions for interdisciplinary interaction and research trends. Materials and Methods: Among the articles in the WoS database, articles containing the word "age" in the title, as well as those containing any of the words "estimation," "determination," "prediction," or "assess- ment," were identified. The filtering feature of the database was used to investigate the language of these articles, publication year, journal of publication, authors, affiliations of authors, countries where the studies were conducted, citation counts of the articles, and the financial support received for the studies. Results: It was found that 990 (97.1%) of the 1020 articles within the scope of our study were published in English, the works have received a total of 23704 citations since their publication, 993 (97.4%) of the articles examined were included in journals indexed within the scope of SCI-E, and the most studies were conducted in Germany with 145 articles (10.4%). Conclusions: The study findings shed light on the bibliometric analysis of countries, institutions, and research- ers involved in forensic age estimation based on the analysis of articles available in the WoS database. This study is the first of its kind conducted in this field. The obtained information can serve as a valuable resource for researchers, academics, and other stakeholders, contributing to the guidance of future research on age estimation.Öğe Analysis of the correlation between thyroid hormones and thyroid volume by gender: a volumetric computed tomography study(2022) Öner, Serkan; Seçgin, Yusuf; Öner, Zülal; Toy, ŞeymaThe aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland\rvolume with volumetric analysis performed by using computed tomography (CT) images. In this retrospective study, IV contrasted thoracic CT images taken for different\rindications between 2019 January and 2020 January were scanned from the archive system of the hospital. 67 (31F, 36M) individuals chosen randomly among patients\rwhose CT results were reported as normal and who had taken thyroid hormone tests within the past week were included in the study. Images in Digital Imaging and\rCommunications in Medicine format were transferred to the personal work station program (Horos Medical Image Viewer). By using the Region of Interest (ROI) console\rin the current program, a three dimensional model was obtained by drawing the border of the thyroid gland in sections varying between 15 and 25. Volume values of this\rthree-dimensional model and TSH, T3, T4 values of the individuals were compared. While no correlation was found between thyroid gland volume and T3 and T4 hormones, a negative significant correlation was found with TSH. In terms of gender, thyroid gland volume, T3, T4 values were found to be statistically significantly higher in\rwomen when compared with men (p?0.05). TSH value was found to be higher in women when compared with men (p=0.005). No statistically significant difference was\rfound in T4 value (p=0.057). Radio-anatomical volumetric data of the thyroid gland presented in this study and its correlation with thyroid functions will be beneficial to\rclinicians working in the field in both internal and surgical medicine branches and will also guide future studies.Öğe Arteria renalis varyasyonları: bir multidetektör bt anjiyografi çalışması(2019) Öner, Serkan; Öner, ZülalAmaç: Aorta abdominalis’in bir çift dalı olan arteria renalis (AR)’invaryasyonları oldukça sık görülmektedir. Literatürde farklı popülasyonlardakadavra çalışmaları ve görüntüleme yöntemleri ile buvaryasyonlar gösterilmiştir. Bu çalışmanın amacı MD-BTA ile ARçaplarını, sayılarını, orjin seviyelerini ve dallanmalarını değerlendirmekve saptanan varyasyonların literatürde yer alan sonuçlarlakarşılaştırmasını yapmaktır.Materyal ve Metot: Çalışmaya 18–85 yaş arası 206 olguya ait BTAgörüntüsü dahil edilmiştir. Tüm görüntüler deneyimli bir radyolog tarafındaniki ve üç boyutlu rekonstrüksiyonlarla analiz edilmiştir. ARçapları, sayıları, dallanmaları ve çıkış düzeyleri değerlendirilmiştir.Bulgular: Toplam 412 böbrekte, 71 çoklu AR ve 32 erken dallanmaolmak üzere %50 AR varyasyonu saptandı. Çoklu AR ve erkendallanma prevelansı erkeklerde sırasıyla %39,7, %34,9 iken,kadınlarda sırasıyla %26, %18,8 olarak gözlendi. En çok gözlenenvaryasyon sağ veya sol böbrekte aksesuar bir AR bulunması şeklindeydi(%23,5). AR çapları sağ böbrek arterleri için ortalama 5,17mm (1,8–7,9 mm), sol AR için 5,13 mm (1,5–9,1 mm) bulundu. TümAR orjin düzeyleri T12 corpus vertebralis ile L4–5 discus intervertebralismesafesi arasında olup; en sık L1 corpus vertebralis (%46)seviyesindeydi.Sonuç: Sonuç olarak AR’de normal paterne göre %50 oranındavaryasyon görülmekte olup; bu varyasyonlarının bilinmesi böbrektransplantasyonu açısından önemlidir. BTA, bu varyasyonların gösterilmesindeoldukça faydalı ve etkin bir yöntemdir.Öğe Associating craniofacial morphometry determined by photo analysis with somatotype in healthy young individuals(2023) Toy, Şeyma; Senol, Deniz; Öner, ZülalObjectives: Evaluation of the relationship between craniofacial parameters and somatotype provides important contributions to specialist physicians and anatomists in determining diseases and obtaining objective results of anthropometric measurements. The study was designed in line with this hypothesis and the aim was to find out how this relationship changed in healthy individuals. Methods: The study was conducted by examining 191 healthy individuals between the ages of 18 and 30. The individuals’ faces were photographed from a distance of 1 meter and craniofacial parameters were measured in Image J program. Somatotype analysis was conducted by using Heath-Carter somatotype method. Results: As a result of our study, the individuals were found to be grouped in four classes according to Heath-Carter somatotype method: (1) mesomorph endomorph, (2) endomorph ectomorph, (3) endomorph mesomorph and (4) central. Significant correlation was found between the second and first somatotype groups in terms of total nasal length, while significant correlation was found between second and first/second and third/fourth and third/first and third somatotype groups in terms of body mass index (BMI) parameter (p < 0.05). Craniofacial parameters were also evaluated and a very high correlation was found between total facial height and mandibular height, while there was a high correlation between total facial height and the other 16 parameters. Conclusions: As a result of our study, a relationship was found between somatotype groups and craniofacial parameters, within craniofacial parameters, and between somatotype and BMI. We believe that this relationship will guide morphological studies in basic medical sciences and surgical interventions in clinical sciences.Öğe Can insulin resistance be predicted with vitamin b12, ferritin, vitamin d and demographic information using machine learning algorithms?(2024) Yıgıt, Meltem; Seçgın, Yusuf; Öner, Zülal; Olukman, ÖzgürIn this study, we aimed to investigate the relationship between insulin resistance and vitamin D, vitamin B12 and ferritin levels. Between January 2022 and October 2023, 322 patients (133 females, 189 males) between the ages of 3-16 years who were admitted to the Pediatrics outpatient clinics of İzmir Bakırçay University Çiğli Training and Research Hospital were included. Pediatric patients with no known chronic disease and measured vitamin B12, vitamin D, ferritin and HOMA- IR levels were retrospectively included in the study. Individuals with HOMA-IR<2.5 were considered as (normal) controls and those with HOMA-IR?2.5 were considered as insulin resistant children. HOMA-IR groups were predicted with an accuracy rate of 0.80 with the Random Forest (RF) algorithm, one of the machine learning algorithms. In addition, the highest contribution of RF to the determination of HOMA-IR with the SHAP analyzer was found to be provided by age, followed by vitamin B12. The results of the study revealed that vitamin B12, vitamin D, ferritin level and age are important factors on insulin resistance. Early vitamin D, vitamin B12 and ferritin replacement is important for the control of metabolic diseases in the future.Öğe The correlation between deformity and metatarsus projection area and the ratios of projection to all metatarsi in direct radiographs in hallux valgus cases(2020) Yedıgül, Meral; Öner, Serkan; Öner, ZülalAim: Hallux valgus (HV) is a common deformity where the hallux deviates laterally in the metatarsophalangeal joint. Although variousradiographic measurements have been developed to assess HV, not all are considered universally necessary and the correlationsbetween these methods were not determined. The present study aimed to investigate the correlation between the metatarsus (MT)projection area and the projection rates to all MTs and deformity observed in direct radiographs in HV cases.Material and Methods: We retrospectively analyzed foot radiographs of 100 female cases (20-60 years old). The cases were dividedinto two groups of 50 HV and 50 non-HV based on HV angles (HVA). HVA>15? was accepted as HV. The MT projection areas and theprojection rates to all MTs, HVA, and intermetatarsal angle (IMA) were measured in HV cases. Paired t-tests were used to comparecontinuous numeric variables (Significance: p ? 0.05).Results: HVA was higher in HV cases (mean, 22.2?) when compared to the non-HV group (mean, 7.4?) (p = 0.000). There was nodifference between the mean MT projection areas in HV and non-HV groups. While there was no significant difference between theratios of the projection area in MT I, II, III and IV to total MT area in HV and non-HV groups, the ratio of the projection area of MT V tothe total MT area was lower in HV cases when compared to that of the non-HV group (p = 0.027).Conclusion: Although it was observed that HV did not affect the projection area of each MT, when the total MT area was considered,it was observed that the projection area of MT V was lower. This finding supported that HV is a condition that affects the whole foot.Öğe Determination of gender by machine learning algorithms, through using craniocervical junction parameters and dimensions of the cervical spinal canal(2023) Taşkın Şenol, Gamze; Kürtül, İbrahim; Ray, Abdullah; Ahmetoglu, Gülçin; Seçgın, Yusuf; Öner, ZülalGender determination is the first step for biological identification. With the widespread use of machine learning algorithms (MLA) for diagnosis, the significance of applying them also in gender determination studies has become apparent. This study has therefore aimed at determining gender from the parameters obtained out of magnetic resonance images (MRI) of the cranio-cervical junction and cervical-spinal canal by using MLA. MRI of the craniocervical junction and cervical-spinal canal of 110 men and 110 women were included in this study. The 15 parameters were tested with Decision Tree (DT), Random Forest (RF), Logistic Regression (LR), Linear Discriminant Analysis (LDA), Quadratic Discriminant Analysis (QDA) algorithms. Accuracy (Acc), Specificity (Spe), Sensitivity (Sen), F1 score (F1), Matthews-correlation coefficient (Mcc) values were used as performance criteria. The Acc, Spe, Sen, F1, and Mcc were found to be 1.00 in the LR, LDA, QDA and RF algorithms. The ratios of the Acc, Spe, Sen, and F1 were 0.98, and of the Mcc was 0.96 in the DT algorithm. It was found that the ratio between the SHAP analyzer of the RF algorithm and the belt of the ratio between the arch of the atlas and the anterior-posterior distance of the dens (R3) parameter had a higher contribution to the estimation of gender compared to other parameters. It was concluded that the LDA, QDA, LR, DT and RF algorithms applied to the parameters acquired from the MRI of the craniocervical junction and cervical-spinal canal, could determine the gender with very high accuracy.Öğe Estimation of gender by using decision tree, a machine learning algorithm, with patellar measurements obtained from mdct images(2021) Öner, Serkan; Turan, Muhammed Kamil; Öner, ZülalAim: The present study aimed to analyze whether gender could be determined with the decision tree (DT) method, a machine learning algorithm, based on patellar multidetector computed tomography (MDCT) image measurements. Material and Methods: The study was conducted on 219 male and 131 female MDCT images. The patellar anteroposterior (Ap), craniocaudal (Cc), transverse (Trv) length and volume (Vol), adjusted on the orthogonal plane by the radiologist, were calculated. In patellar length measurements, initially linear discriminant outliers were detected to clear the data for gender prediction. Accuracy (Acc), Sensitivity (Sen), Specificity (Spe), F1-Score (F1) and Matthew’s Correlation Coefficient (Mcc) criteria were taken as the performance criteria for DT. Results: It was determined that male Ap, Trv, Cc, and Vol values were higher when compared to the female values and there was a significant difference between these values based on gender (pAp, Trv, Cc, Vol = 0.000). Using the above-mentioned measurements, it was calculated that the prediction rate for male individuals was 98.2% and for female individuals, it was 98.4%. Conclusion: DT analysis based on patella morphometry provided a simple, adequate and highly accurate approach for gender estimation. Furthermore, it was determined that it would provide an advantage for researchers in gender prediction using only branching and cut-off values on the tree structure without the need to use a computer.Öğe An evaluation of spinal deformities and quality of life in male patients with ankylosing spondylitis(2014) Canbay, Özden; Köse, Evren; Öner, Zülal; Altay, Zuhal; Ekıncı, NihatAmaç: Postür, vücudun her hareketinde eklemlerin aldığı pozisyonların birleşimidir. Çalışmamızın amacı; Ankilozan Spondilit'li (AS) hastalarda postür analizine bakılarak omurga deformitelerinin belirlenmesi ve bunların AS'li hastaların günlük yaşam aktiviteleri ve kalitesi üzerine nasıl bir etkide bulunduğunun araştırılmasıdır. Gereç ve Yöntem: Çalışmaya 30 AS'li ve 30 sağlıklı birey alındı. Tüm bireylere postür analizi, SF-36 yaşam kalitesi değerlendirme anketi ve Beck Depresyon ölçeği uygulandı. Kaslarda kısalık ve kas kuvveti değerlendirildi. Bulgular: Postür analizi değerlendirmesi sonucunda hasta bireylerin torakal kifoz artışı, lumbal lordozda azalma, yuvarlak omuz, genu valgum ve pes planus deformitelerinin anlamlı oranda arttığı gözlendi. Vücut kitle indeksi ortalamaları ile postür analizi sonuçlarından servikal lordozda artış, düşük omuz ve genu varum açısından anlamlı bir fark bulunmadı. Belirli kas gruplarında ise kas kuvvetinde azalma ve kas kısalığı tespit edildi. Ankilozan spondilit'li hastalarda yaşam kalitesinin postüre bağlı olarak olumsuz etkilendiği belirlendi. Sonuç: Ankilozan spondilit'li hastalarda postürün bozulduğu, kaslardaki kısalığın hareketleri sınırlandırdığı ve buna bağlı olarak ortaya çıkan kas zayıflamasından dolayı yaşam kalitesinin düştüğü düşünülmektedir. Ayrıca eğitim seviyesi düşük olan bireylerin, hastalık hakkında yeterli bilgiye sahip olmadığı ve gereken önemi göstermedikleri görülmektedirÖğe Gender prediction with parameters obtained from pelvis computed tomography images and decision tree algorithm(2021) Seçgin, Yusuf; Öner, Zülal; Turan, Muhammed Kamil; Öner, SerkanGender prediction is among the most critical topics in forensic medicine and anthropology since it is the basis of identity (height, weight, ancestry, age). Today, osteometry which is a low-cost, easily accessible method that requires no expertise is preferred when compared to DNA technology, which has several disadvantages such as high cost, accessibility, laboratory facilities, and expert personnel requirements. The Computed Tomography (CT) method, which is little affected by orientation and provides reconstruction opportunities, was selected instead of traditional methods for osteometry. This study aims to predict high and accurate gender with the Decision Tree (DT) algorithms used in the field of health recently. In the present study, CT images of 300 individuals (150 females, 150 males) without a pathology on the pelvic skeleton and between the ages of 25 and 50 were transformed into orthogonal form, landmarks were placed on promontorium, sacroiliac joint, iliac crest, terminal line, anterior superior iliac spine, anterior inferior iliac spine, greater trochanter, obturator foramen, lesser trochanter, femoral head, femoral neck, the body of femur, ischial tuberosity, acetabulum, and pubic symphysis, and the coordinates of these landmarks were determined. Then, parameters such as angle and length were obtained with various combinations. These parameters were analyzed with the DT algorithm.The analysis conducted with the DT algorithm revealed that accuracy (Acc) was 0.93, sensitivity was 0.95, specificity was 0.90, and the Matthews correlation coefficient was 0.86 for the pelvic skeleton. It was observed that the accuracy was quite high and more realistic when determined with the DT algorithm. In conclusion, the DT algorithm with multiple parameters and samples on pelvic CT images could improve the Acc of gender prediction.Öğe Sekazu: an integrated solution tool for gender determination based on machine learning models(2021) Turan, Muhammed Kamil; Sehırlı, Eftal; Öner, Zülal; Öner, SerkanGender determination is the first stage of identification used in forensic investigation, anthropology, archeology, and bioarchaeology, which helps accelerate the process of narrowing possible matches in a medical-legal context. Without DNA analysis, the dimorphic property of bones comprises a basis for gender determination with measurements taken on only bones. In this work, 9 different bones such as cranium, mandibula, femur, patella, calcaneus, condylus occipitalis, sternum, hand bones, and foot bones were used for gender determination. Machine learning methods and artificial neural networks, especially linear and quadratic discriminant analysis, while determining the gender, machine learning also were technically adopted. 13 different machine learning algorithms were used as a model for gender determination. Many tools were designed to perform processes like designing necessary bookmarks to try models, designing measurements where machine learning algorithms are used as features, determining coordinates of designed bookmarks, and computation of features. A software named Sekazu was developed by presenting an integrated solution proposal. Thanks to the developed software, models used in gender determination were developed and tried in a fast way and researchers can obtain results reported based on performance metrics flexiblyÖğe Usage length of sternum components and sternal angle through images obtained by computerized tomography image reconstruction in gender determination(2019) Öner, Zülal; Öner, Serkan; Kürtül, İbrahim; Şahin, BünyaminAim: This study investigates the total sternum length and the lengths of each part of the sternum using computed tomography (CT) images oriented orthogonally to reveal whether there are any significant gender differences with respect to these values.Material and Methods: Thin-section thorax CT images from 60 subjects (30F, 30M) between 20 and 40 years of age were used, oriented to the orthogonal plane using an image-processing program.The sternal angle (SA), manubrium length (ML), corpus length (CL), xiphoid processlength (XPL), total sternum length (TSL), manubrium-corpus length proportion (sternal index; SI), and the proportion of the three parts separate from the TSL were compared by gender.Results: The values of the ML (M: 5.36 cm, F: 4.76 cm), CL (M: 10.11 cm, F: 8.75 cm), and TSL (M: 19.18 cm, F: 16.28 cm) were longer in males (p?0.05) than in females. No statistically significant difference was determined in the ratios of the XPL, SI, and sternum parts to the TSL (p>0.05). The mean values of the SA in males and females were 161.4° and 160.51°, respectively (p>0.05). In an ROC analysis, the most significant measurement for gender determination was found to be the CL, and the linear discriminant analysis yielded a correct determination rate of 86% for males and 93% for females.Conclusions: Although metric measurements of the sternum could provide high accuracy rates in gender determination, to increase reliability, image analyses should be conducted in the orthogonal plane to remove errors that could be caused by the differences in orientation.Öğe Wistar albino sıçanlarda doksorubisin ile indüklenen kardiyotoksisiteye karşı linalool’ün koruyucu ve tedavi edici etkileri(2019) Öner, Zülal; Altınöz, Eyüp; Elbe, Hülya; Ekıncı, NihatDoksorubisin (DOX), antrasiklin grubuna dahil antineoplastik bir ajandır. Antitümöral bir ilaç olan DOX’un oksidatif stresi artırarak kardiyomiyopatiye neden olduğu gösterilmiştir. Bu çalışmanın amacı ratlarda DOX ile indüklenen kardiyotoksisiteye karşı, bir antioksidan olan Linalool’ün (LIN) koruyucu ve tedavi edici etkilerini histolojik ve biyokimyasal olarak ortaya koymaktır. Çalışmamız için yerel etik kurul onayı alınmıştır. Deneyde, ağırlıkları ortalama 250-300 gr olan 64 adet erkek Wistar Albino sıçanlar kullanıldı ve rastgele 8 gruba ayrıldı (n=8). Grup 1 kontrol grubu (%0.9’luk serum fizyolojik), grup 2 DOX grubu (20mg/kg DOX), grup 3 LIN50 grubu (50 mg/kg LIN), grup 4 LIN100 grubu (100 mg/kg LIN), grup 5 DOX+LIN50 grubu (20mg/kg DOX ve 50 mg/kg LIN), grup 6 DOX+LIN100 grubu (20mg/kg DOX ve 100 mg/kg LIN), grup 7 LIN50+DOX grubu (50 mg/kg LIN ve 20mg/kg DOX), grup 8 LIN100+DOX grubu (100 mg/kg LIN ve 20mg/kg DOX). Grup 5 ve 6’ya DOX uygulaması sonrası 5 gün süreyle LIN uygulanmış, Grup 7 ve 8’e ise 5 gün süreyle LIN uygulaması sonrası DOX uygulanmıştır. 5 günlük tedavi sürecinin arkasından tüm sıçanlar ketamin/ksilazin anestezisi altında sakrifiye edilerek kan ve kalp dokusu alındı. DOX grubunun ortalama histopatolojik hasar skoru 8.37 ± 0.32 idi. DOX+LIN50 ve DOX+LIN100 gruplarında histopatolojik değişikliklerin belirgin olarak azaldığı ve LIN50+DOX ve LIN100+DOX gruplarında hasarın LIN uygulaması ile önlendiği tespit edildi. DOX grubu ile kontrol, LIN50 ve LIN100 grupları ile karşılaştırıldığında, apopitotik hücrelerde kaspaz-3 immün boyanması çok belirgindi (p<0.001, hepsi için). DOX grubu ile karşılaştırıldığında tedavi gruplarındaki kaspaz-3 immün boyanmasının yoğunluğu azalmıştı (p<0.05). DOX ile birlikte LIN uygulandığında MDA, plazma CK ve LDH seviyelerinde anlamlı düşüşe, GSH, SOD ve CAT enzim seviyelerinde anlamlı artışa sebep olduğu görülmüştür. Sonuç olarak DOX’un ağır kardiyotoksisite geliştirdiği, DOX ile birlikte LIN verilmesi kardiyomiyopati bulgularını ortadan kaldırabileceği ve LIN’in hem 50mg hem de 100mg’lık dozlarının DOX’a bağlı kardiyotoksisiteden koruyabileceği ve tedavi edici etkisi olabileceği kanısına varılmıştır.
