Yazar "Akyuz, Mufit" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Accuracy of the methods used to estimate glomerular filtration rate compared to 24-hour urinary creatinine clearance in patients with chronic spinal cord injury(Taylor & Francis Ltd, 2023) Hazer, Burcu; Onder, Fatih Oguz; Metli, Neslihan Bilge; Aslan, Sirin Baran; Yalcin, Elif; Akyuz, MufitObjective To compare the accuracy of glomerular filtration rate (GFR) estimation by 24-hour urinary creatinine clearance with GFR estimation by the Modification of Diet in Renal Disease (MDRD) equation, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, the Mayo Clinic Quadratic equation (MCQE), and the modified Cockcroft-Gault formula in patients with spinal cord injury (SCI). Design Cross-sectional study. Participants Fifty-nine consecutive subjects, who were admitted to our hospital SCI rehabilitation and no additional acute medical disorders, were enrolled in this study. A 24-hour urine sample was collected for the determination of 24-hour urinary creatinine clearance, which was assumed as the standard technique for estimation of the GFR. The accuracy of several estimation formulas includes the 4-variable MDRD equation, the 6-variable MDRD equation, the Cockcroft and Gault equation, the CKD-EPI equation, and the MCQE. Results GFRs calculated by the Cockcroft-Gault equation and 4-variable MDRD were significantly different from the 24-hour urinary creatinine clearance, whereas there were no significant differences in GFRs calculated by CKD-EPI (P = 1.000), Mayo Clinic Quadratic formula (P = 0.794), and 6-variable MDRD equations (P = 0.435) and 24-hour urinary creatinine clearance. Both the 6-variable MDRD equation and CKD-EPI were accurate within +/- 20 of the reference methods in 52.54% of the subjects. Conclusions Among the methods used for estimation of the GFR including the 4- and 6-variable MDRD, the CKD-EPI, the modified Cockcroft-Gault equation, and the MCQE, the 6-variable MDRD equation and the CKD-EPI demonstrated best performance to estimate the GFR. However, none of the formulas were sufficient to estimate the GFR in SCI patients accurately.Öğe Adiponectin in spinal cord injury: What is the role of nutrition in serum adiponectin concentration?(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2024) Adiguzel, Emre; Adiguzel, Kubra Tel; Ozisler, Zuhal; Kaner, Gulsah; Akyuz, MufitObjectives: The study aimed to analyze the relationship between serum adiponectin concentration, Mediterranean diet (MD) adherence, and Dietary Approaches to Stop Hypertension (DASH) diet adherence in patients with spinal cord injury (SCI). Patients and methods: Thirty-three SCI patients (21 males, 12 females; median age: 33 years; range, 18 to 65 years) and 33 age-, sex-, and body mass index-matched healthy controls (21 males, 12 females; median age: 33 years; range, 18 to 64 years) were included in this crosssectional study between March 2021 and March 2022. Serum adiponectin concentrations of all participants were measured. Body weight, height, and neck, hip, waist, and mid-upper arm circumferences were measured. Twenty-four-hour dietary records were obtained by the researchers for evaluation of the nutritional status. The DASH diet score and MD score were measured for each participant. Results: Most of the cases of SCI were due to motor vehicle collisions (n=12, 36.4%) and complete paraplegic. Mid-upper arm circumference, waist circumference, hip circumference, and neck circumference of the patient group were significantly higher than the control group (p=0.020, p=0.002, p=0.042, and p<0.001, respectively). Mediterranean diet scores and DASH diet scores of the patient group were significantly higher than the control group (p<0.001 and p=0.031, respectively). Serum adiponectin concentration of patients was significantly higher than the control group (p=0.049). No correlation was detected between adiponectin concentration, MD score, and DASH diet score in both groups. Conclusion: Although correlation analysis in the current research did not show significant relation between nutrition and adiponectin concentrations, nutrition of patients with SCI, as demonstrated by higher adherence to MD and DASH, may have provided positive effects on adiponectin concentrations. Future studies focused on the effect of a healthy diet intervention on serum adiponectin concentration is warranted.Öğe ALKAPTONURIA DIAGNOSED IN A GERIATRIC PATIENT; A CASE REPORT(Gunes Kitabevi Ltd Sti, 2020) Gunduz, Ramazan; Ustun, Betul; Uran San, Ayca; Karatas, Hatice Gulsah; Akyuz, MufitAlkaptonuria is a hereditary and metabolic disease which is characterised by ocranosis, arthritis and aciduria. It is a rare clinical condition which has an estimated incidence varies from 1/ 250,000 to 1/1000000 live births. This autosomal recessive disorder occurs as a result of homogentisic acid dioxygenase enzyme deficiency which takes part in tyrosine metabolism.This case reportaimed to present a geriatric patient who had diagnosed alkaptonuria. A 69 years old male was admitted to our department with knee-shoulder pain and range of motion (ROM) limitation. His medical history revealed that he had both mechanical and inflammatory joint pain for 22 years.The examination of his eyes were compatible with blue sclera and there was also bluish black discoloration on the ears. He had also hearing loss. Qualitative 24 hours collected urine examination showed dark black discoloration. The patient was diagnosed as alkaptonuria. A physical therapy programme were planned to the patient by our department. Clinicians should be aware of this pathology and the diagnosis should be confirmed by clinical, laboratory and radiological examinations.Öğe Dynamic thiol and disulphide homoeostasis in fibromyalgia(Termedia Publishing House Ltd, 2020) Karatas, Gulsah; Gunduz, Ramazan; Haskul, Ismail; Ustun, Betul; Neselioglu, Salim; Karatas, Fatih; Akyuz, MufitIntroduction: Thiol and disulphide levels are biomarkers that provide useful information about oxidative stress and antioxidant capacity, showing a different homoeostasis in inflammatory and proliferative diseases. We aimed to clarify the possible aetiology of this disease by using thiol and disulphide levels in patients with fibromyalgia, the basis of which has not yet been clearly elucidated. Material and methods: A total of 156 individuals: 86 patients with fibromyalgia and 70 age-matched controls were included in this prospective non-randomised case-control study. Demographic characteristics including smoking status, body mass index (BMI), the duration of complaints, and pain levels were carefully recorded. Dynamic thiol-disulphide homoeostasis in blood samples was determined by an automatic-spectrophotometric method. The Mann-Whitney U and Student's t-test were used to determine the differences between the groups. Results: Sex, BMI, and smoking status were similar between the groups (p = 0.62, p = 0.09, and p = 0.64, respectively). While native thiol levels were found to be high in patients with fibromyalgia (p = 0.018), disulphide levels and the rates of disulphide/native thiol and disulphide/total thiol were significantly low (p = 0.049, p = 0.007, and p = 0.007, respectively). Correlation analysis showed no significant relationship between thiol-disulphide levels and duration of complaints or pain level. Conclusions: Thiol-disulphide balance in fibromyalgia was found to be similar to benign proliferative diseases, suggesting that the underlying mechanism is more likely to be of proliferative pattern rather than inflammatory. Additionally, fibromyalgia is not directly associated with increase in oxidative stress. The molecular mechanisms need to be elucidated.Öğe The effect of electromyography triggered electrical stimulation to abdominal muscles on sitting balance, respiratory functions, and abdominal muscle thickness in complete spinal cord injury: a randomized controlled trial(Lippincott Williams & Wilkins, 2024) Bayraktar, Handan E. N.; Yalcin, Elif; Sipal, Meric S.; Akyuz, Mufit; Akinci, Meltem G.; Delialioglu, Sibel U.Complete thoracic spinal cord injury (SCI) results in a loss of innervation to the abdominal muscles, which affects trunk stability and performance of activities of daily living from a sitting position. Respiratory function is also affected, leading to frequent pulmonary complications. Given the importance of trunk stability and respiratory function, we investigated the effects of electromyography triggered electrical stimulation (EMG-ES) applied to the abdominal muscles on sitting balance, respiratory functions and abdominal muscle thickness in individuals with complete thoracic SCI. This randomized controlled study included 34 participants with complete thoracic SCI who were randomly allocated to the experimental group (n = 17) and the control group (n = 17). During the 4-week intervention period, the experimental group received EMG-ES to their abdominal muscles, while the control group received isometric abdominal exercises three times per week. Both groups continued with their routine rehabilitation program (active or passive range of motion exercises, stretching, and balance coordination exercises). The primary outcome measures were the modified functional reach test (mFRT) and trunk control test (TCT). Secondary outcome measures included a pulmonary function test (PFT) and the bilateral abdominal muscle thicknesses using ultrasonography. At the end of the study, the experimental group showed significantly greater improvements in both primary outcomes. The mean difference in pre-post changes between the groups for the mFRT area was 242.8 cm(2) [95% confidence interval (CI): 181.3-329.8; effect size 0.92; P < 0.001] and 5.0 points for TCT (95% CI: 3.9-6.0; effect size 0.98, P < 0.001). The increase in the abdominal muscle thickness was also significantly greater in the experimental group (P < 0.001) without significant differences in the PFT (P > 0.05). We conclude that adding EMG-ES of abdominal muscles may further improve sitting balance and abdominal muscle thickness in individuals with complete thoracic SCI. Copyright (c) 2024 Wolters Kluwer Health, Inc. All rights reserved.Öğe The effects of carpal tunnel syndrome on sleep quality(2020) Karataş, Gülsah; Kütük, Öznur; Akyuz, Mufit; Karaahmet, Özgür Zeliha; Yalçın, ElifAim: Carpal tunnel syndrome (CTS) is the most common mononeuropathy of the upper extremities. The aim of this study was toinvestigate the relationship between different compression levels and sleep quality in patients with clinically and electrophysiologicallydiagnosed CTS.Material and Methods: Patients with CTS diagnosed by electroneuromyographic evaluation and healthy controls were included inthe study. Demographic characteristics and disease symptoms were recorded carefully. The Boston Carpal Tunnel Questionnaire[symptom severity scale (SSS) and functional status scale (FSS)] was used to assess the severity of symptoms. Pittsburgh SleepQuality Index (PSQI) was used to evaluate sleep quality and disorders.Results: A total of 94 CTS patients (80 female, 14 male) and 33 healthy controls were included. The median ages were similar among thegroups (patient vs. control, mild-CTS vs. moderate-CTS, unilateral CTS vs. bilateral CTS; p = 0.11, p = 0.54, p = 0.22, respectively). Themean PSQI of patient group was higher than control group (7.81 ± 3.97 vs. 3.66 ± 2.08, p=0.000). While PSQI values were significantlydifferent (p= 0.03) between unilateral-CTS and bilateral-CTS patients, no significant difference was observed in Boston-SSS, BostonFSS, and total Boston values (p= 0.51, p= 0.29, p= 0.34 respectively). There was no significant difference between patients with mildCTS and those with moderate-CTS in terms of PSQI, Boston-FSS, Boston-SSS, and total Boston values (p= 0.61, p= 0.54, p= 0.62, andp= 0.53 respectively). There was a positive correlation between PSQI and Boston-SSS, Boston-FSS, and total Boston values (p <0.001).Conclusion: Sleep quality was significantly affected in CTS patients, with a significant decrease in sleep time. While an increase inelectrophysiological severity in patients with CTS did not affect the sleep quality, an increase in symptom severity decreased thesleep quality, with the greatest effect observed in patients with bilateral CTS.Öğe THE EFFECTS OF THE LEVEL OF SPINAL CORD INJURY ON LIFE SATISFACTION AND DISABILITY(Literatura Medica, 2020) Karatas, Gulsah; Metli, Neslihan; Yalcin, Elif; Gunduz, Ramazan; Karatas, Fatih; Akyuz, MufitIntroduction - Spinal Cord Injury (SCI) may often lead to significant disability in affected individuals and reduce life satisfaction. Herein we aimed to investigate the effects of the level of injury on disability and life satisfaction as well as the relation between life satisfaction and disability. Methods - Patients with at least one-year history of SCI were included. Demographic-clinical data of patients were recorded. The Craig Handicap Assessment and Reporting Technique-Short Form (CHART-SF) was used for quantifying the degree of patients' disability. Life satisfaction was assessed by the Satisfaction with Life Scale (SWLS). Results - Of the 76 patients, 21 (27.6%) were tetraplegic and 55 (72.4%) were paraplegic. SWLS was found to be similar in tetraplegic vs. paraplegic patients (P=0.59), whereas CHART parameters such as physical independence, mobility, occupation, and total CHART value were significantly higher in paraplegic patients (P=0.04, P=0.04, P=0.001 and P=0.01, respectively). Social integration was found similarly high in both groups. There was a positive correlation between elapsed time after the injury and CHART physical independence, occupation and the level of economic sufficiency (P<0.01, P<0.01, P=0.01). Excluding the economic sufficiency (P=0.02), there was not any other association between the rest of CHART parameters and SWLS. Conclusions - According to our findings, although the level of injury seems to be influential on disability, it seems to have no significant effect on life satisfaction. Since the only thing that positively affects life satisfaction is economic sufficiency, more emphasis should be placed on regulations that increase the return to work in patients.Öğe Enhancing balance and mobility in incomplete spinal cord injury with an overground gait trainer(Springernature, 2024) Sipal, Meric Selim; Yildirim, Sinem; Akinci, Meltem Gunes; Dincer, Sezen; Akyuz, MufitStudy designProspective intervention study.ObjectivesThe study aimed to assess the effect of Andago on balance, overground walking speed, independence levels, fear of falling, and quality of life in patients with acute motor incomplete Spinal Cord Injury.SettingThe study was conducted in Ankara/T & uuml;rkiye.MethodsFive participants, classified as AIS D, underwent an eight-week treatment regimen, including three days a week of Andago-assisted walking and balance exercises, supplemented by two days a week of 40-minute sessions of conventional in-bed exercises.ResultsBerg Balance Scale scores increased significantly by 129% (p = 0.043). Overground walking speed calculated from 10MWT improved by 33% (p = 0.042). WISCI II levels improved significantly compared to baseline scores (p = 0.041). In the mobility subscale of SCIM III, the total SCIM III scores increased significantly (p = 0.042, p = 0.043, respectively). However, there was no significant improvement in WHOQOL-BREF scores (p = 0.080).ConclusionsThe use of Andago facilitated functional progress in patients with acute incomplete SCI, emphasizing the importance of challenging balance and walking activities in triggering motor learning.Öğe A Rare Condition of Vertebral Squaring Accompanied by Hereditary Spherocytosis(Coll Physicians & Surgeons Pakistan, 2022) San, Ayca Uran; Tezce, Ahmet; Karatas, Hatice Gulsah; Ustun, Betul; Gunduz, Ramazan; Akyuz, MufitVertebral squaring is a radiological term which defines straightening of the ventral section of vertebral body. This condition generally occurs as a result of rheumatological inflammation such as ankylosing spondylitis. There are also several other clinical conditions rarely giving rise to this change, like Paget's disease, inflammatory arthritis, and Down's syndrome. To the best of our knowledge, this is the first case of vertebral squaring accompanied by hereditary spherocytosis (HS) in literature. HS is a relatively rare condition of hemolytic anaemia due to red cell membrane defects. A 28-year male was admitted to our department with low back pain. The patient had been diagnosed with HS. On radiological examination, vertebral squaring was detected by lateral radiograph and MRI of the lumbar spine. The detection of vertebral squaring is often confusing as the clinical picture may mimic other pathologies. The diagnosis should be confirmed by laboratory and radiological assessments.Öğe The relation between the bladder drainage types and sleep quality on patients with spinal cord injury(2020) Karataş, Gülsah; Metlı, Neslihan Bilge; Akyuz, Mufit; Özısler, Zuhal; Yalçın, ElifObjectives: Intermittent self-catheterization (IsC) improves self-care, independence, body image, and expression ofsexuality, reducing the risk of urethral trauma and urinary tract infections. However, increased frequency of catheterization,especially nocturnal catheterization, may disturb the sleep process and reduce the quality of life (QoL).Methods: Sixty patients with spinal cord injury (SCI), 29 of whom were tetraplegic and 65 were paraplegic, were included.The participants were divided into 4 groups based on the bladder drainage types as spontaneous voiding,IsCx4 (4 times a day), IsCx6 (6 times a day), and permanent catheterization. Pittsburgh Sleep Quality Index (PSQI) andSatisfaction with Life Scale (SWLS) were used to assess sleep quality and life satisfaction of the participants. PSQI andSWLS were compared between the groups.Results: The mean age of the patients was 35.06±13.28 years. Median time from SCI was 22 (6-276) months. PSQI andSWLS values were similar among the groups based on the types of voiding (p=0.24, and p=0.68, respectively). In eachgroup, the SWLS and PSQI were correlated with poor life satisfaction and poor sleep quality, respectively.Conclusion: Although we thought that the increased frequency of IsC could affect the sleep quality and life satisfaction,the results of this preliminary study did not support this hypothesis.Öğe When is needle examination of thenar muscle necessary in the evaluation of mild and moderate carpal tunnel syndrome?(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2021) Ozisler, Zuhal; Akyuz, MufitObjectives: This study aims to evaluate the predictors of standard nerve conduction study (NCS) parameters in determining the presence of axonal loss by means of spontaneous activity in patients with mild and moderate carpal tunnel syndrome (CTS). Patients and methods: Between May 2015 and April 2018, a total of 118 patients (11 males, 107 females; mean age: 52.3 +/- 10.6 years; range, 27 to 79 years) who underwent electrophysiological studies and were diagnosed with CTS were included. Demographic data of the patients including age, sex, and symptom duration were recorded. Electrodiagnostic studies were performed in all patients. All the needle electromyography (EMG) findings were recorded, but only the presence or absence of spontaneous EMG activities was used as the indicator of axonal injury. Results: In 37 (31.4%) of the patients, spontaneous activity was detected at the thenar muscle needle EMG. No spontaneous activity was observed in any of 43 (36.4%) patients with normal distal motor latency (DML). There were significant differences in DMLs, compound muscle action potential (CMAP) amplitudes, sensory nerve action potentials amplitudes, and sensory nerve conduction velocities between the groups with and without spontaneous activity (p<0.05). The multiple logistic regression analysis revealed that DML was a significant independent risk variable in determining presence of spontaneous activity. The most optimal cut-off value for median DML was calculated as 4.9 ms. If the median DML was >4.9 ms, the relative risk of finding spontaneous activity on thenar muscle needle EMG was 13.5 (95% CI: 3.6-51.2). Conclusion: Distal motor latency is the main parameter for predicting the presence of spontaneous activity in mild and moderate CTS patients with normal CMAP. Performing needle EMG of the thenar muscle in CTS patients with a DML of >4.9 ms may be beneficial to detect axonal degeneration in early stages.
