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    Hyperglycaemia in the emergency department: Stress hyperglycaemia or diabetes mellitus
    (Scientific Publishers of India, 2017) Koyuncu, M.; Koyuncu, S.; Biberoglu, S.; Benli, A.R.; Koyuncu, S.; Atli, B.; Kostekc, S.K.
    Stress Hyperglycaemia (SH) evolving especially in the acute period of diseases and in post-traumatic patients is appeared in many diabetic and non-diabetic patients. Patients with undiagnosed diabetes mellitus may also present with complications of diabetes, with 5% fatal courses. The aim of this study was to determine the incidence of diabetes mellitus in patients who applied to Emergency Department (ED) for various reasons. The files of the patients were retrospectively examined. The patients were divided into the following groups: Group 0: No prior diagnosis of diabetes. Group 1: Stress hyperglycaemia. Group 2: Diabetes mellitus. Group 3: The patients had not been diagnosed with diabetes mellitus before visiting the emergency department, and they were not taking any treatment for diabetes. Group 4: Newly diagnosed diabetes mellitus. Group 2 had the highest number of patients (64.4%), followed by Group 3 (10.4%), Group 4 (4.3%), and Group 0 (4.1%). The highest average blood glucose values were found in Group 2 (258.00), followed by Group 3 (230.00), and Group 4 (237.00). Undiagnosed patients with diabetes mellitus risk can apply with complications, and this not only threatens the lives of these patients but also dramatically reduces their quality of their life. It should be considered that there could be diabetes mellitus patients, as well as stress hyperglycaemia patients, with a high blood sugar level, in the emergency department. Thus, we believe that patients diagnosed with a high blood sugar level should be advised to attend their family practices and/or a polyclinic for disease monitoring, with follow-up in an endocrine unit. © 2017, Scientific Publishers of India. All rights reserved.
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    The role of heparan sulphate in pathogenesis of Crimean-Congo hemorrhagic fever disease
    (2013) Guven, F.M.K.; Aydin, H.; Kaya, A.; Engin, A.; Kenan, Celik, V.; Korkmaz, I.; Atli, B.
    Background & objectives: Crimean-Congo hemorrhagic fever (CCHF) is a viral infection typically transmitted by tick bite. This study is to define the level of heparan sulphate (HS) in serum/urine since HS may play a role in the pathogenesis of hemorrhagic events in the patients with CCHF. Methods: In this study, the patient group consisted of 79 cases with a positive diagnosis of CCHF according to PCR/ELISA outcome among the patients referred to Cumhuriyet University, School of Medicine in 2010. A total of 81 volunteers who had not any viral or metabolic disease were enrolled as the control group. The blood samples were centrifuged, and the serum and urine samples obtained were stored at -80°C until they were studied. Then, these samples were simultaneously dissolved, and HS level was spectrophotometrically measured using glycosaminoglycans specific 1-9, dimethyl-methylene blue (DMMB) stain. Results: A statistically significant increase in the HSserum values was found both in the individuals under and above 16 yr old in the patient groups compared to the controls (p <0.05). Also there was a statistically significant increase in the urine levels of HS in the cases >16 yr old compared to the controls (p <0.05). Interpretations & conclusion: Increase of the serum/urine levels of HS was though to be due to vascular endothelium damage and to liver injury as well as vascular endothelium damage in the patients who died. Further, comprehensive studies are needed to demonstrate whether the serum/urine levels of HS are correlated to liver and vascular endothelium damage and prognosis of the disease.