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Öğe Calcium antagonists, digoxin, calcaemia and anaemia in heart failure(Scientific Publishers of India, 2017) Yildiz, S.S.; Dikerdem, D.; Benli, A.R.; Kalem, P.; Cikrikcioglu, M.A.Objective: To reveal that Calcium Antagonist (CA) use is associated with lower haemoglobin (Hb) and digoxin use is associated with higher Hb in Heart Failure (HF). Method: 223 chronic HF patients in acute decompensation phase were included in the study. Patients with comorbidities leading to anemia and those receiving blood transfusion or antianaemic treatment were excluded. Patients were classified into two groups as anemic and non-anemic groups. Two groups were compared retrospectively with demographics, clinical findings, medication use, echocardiography findings, complete blood count and biochemistry. Different independent variables between two groups were subjected to Multivariate Binary Logistic Regression Analysis (MBLRA) under the dependent variable anemia. Multivariable linear Regression Analysis (RA) was also performed with the dependent variable of Hb. Results: MBLRA results showed that anemia was seen less frequently in digoxin users, whereas it was more frequent in the following conditions: CA use, chronic renal failure, lower AST, lower LDL cholesterol, lower triglyceride, lower Transferring Saturation Rate (TSR). RA results also showed that lower LDL cholesterol, lower eGFR, lower transferrin saturation rate, lower corrected calcium, female gender and CA use were associated with lower Hb; whereas, digoxin use was associated with higher Hb. Conclusions: Haemoglobin levels were found higher in digoxin users. CA use, lower corrected calcium and lower AST were associated with lower Hb in heart failure. These findings have not been reported so far. © 2017, Scientific Publishers of India. All rights reserved.Öğe The effect of ferritin, vitamin B12 and folic acid on pregnancy outcomes(E-Century Publishing Corporation, 2016) Kalem, P.; Benli, A.R.; Koroglu, M.; Benli, N.C.; Koyuncu, M.; Cesur, O.; Dane, P.B.K.Purpose: A reduction occurs in levels of some minerals and vitamins due to physiological adaptation during pregnancy, and this situation causes anemia in pregnancy. The aim of the present study was to evaluate the effect of ferritin, vitamin B12 and folate levels on outcomes of pregnancy in 3rd trimester pregnant women. Materials and Methods: This retrospective study included a total of 72 pregnant women in the third trimester of pregnancy. Vitamin and mineral analyses of the patients were applied. Patients were questioned in respect of whether or not iron and vitamin supplements were taken during pregnancy, the mode of delivery and the history of postpartum problems in infant. Results: As the number of children increased, so an increase was seen in the incidence of anemia. Of the mothers of newborns with medical problems, 60% had anemia. There was no statistically significant difference in the mean birth weight according to the presence or absence of maternal anemia. Anemia in pregnant women is defined as hemoglobin level below 11.0 g/dL in the first and third trimester and below 10.5 g/dL in the second trimester. No significant difference was determined in anemia status according to the mode of delivery. No difference in anemia was detected in infants, regardless of whether or not their mothers took vitamin and mineral supplements. Conclusion: Anemia in the third trimester has no effect on the mode or time of delivery, weight and general condition of the newborn. To decide the effect of anemia on the outcome of pregnancy, further studies with more participants are needed. © 2016, E-Century Publishing Corporation. All rights reserved.Öğe Evaluation of contacts of the patients with negative covid rt-pcr and thorax ct findings compatible with covid-19 pneumonia(Ankara Yildirim Beyazit University, 2021) Benli, A.R.; Aslaner, H.; Gökçek, M.B.; Çetin, A.; Herdem, N.; Görücü, Y.; Çelik, I.Objectives: This study aimed to evaluate the test results of patients whose RT-PCR test result was negative, but thorax CT findings were compatible with COVID-19 and their infectiousness in terms of contacts. Materials and Methods: The study was designed as cross-sectional, descriptive research. In the first group, thorax CT revealed findings compatible with COVID-19 pneumonia, and the RT-PCR test result was negative. In the second group, thorax CT revealed findings compatible with COVID-19 pneumonia, and the RT-PCR test result was positive. Data collected were assessed with SPSS 21.0 software program. The significance level was accepted as 5%. Results: Of the participants, 54.41% were male, and 45.59% were female. There was no significant difference between the two groups in terms of contact environment and status of being a healthcare worker and exitus. There was no difference between the first and second groups in terms of the number of contacts. The rate of sample collection was higher in the second group. The number of people who had contact with the patients and positive RT-PCR test results was higher in the first group. Conclusion: Even if patients have negative RT-PCR test results for COVID-19, they are still infectious. © 2021 Ankara Yildirim Beyazit University. All rights reserved.Öğe Hyperglycaemia in the emergency department: Stress hyperglycaemia or diabetes mellitus(Scientific Publishers of India, 2017) Koyuncu, M.; Koyuncu, S.; Biberoglu, S.; Benli, A.R.; Koyuncu, S.; Atli, B.; Kostekc, S.K.Stress Hyperglycaemia (SH) evolving especially in the acute period of diseases and in post-traumatic patients is appeared in many diabetic and non-diabetic patients. Patients with undiagnosed diabetes mellitus may also present with complications of diabetes, with 5% fatal courses. The aim of this study was to determine the incidence of diabetes mellitus in patients who applied to Emergency Department (ED) for various reasons. The files of the patients were retrospectively examined. The patients were divided into the following groups: Group 0: No prior diagnosis of diabetes. Group 1: Stress hyperglycaemia. Group 2: Diabetes mellitus. Group 3: The patients had not been diagnosed with diabetes mellitus before visiting the emergency department, and they were not taking any treatment for diabetes. Group 4: Newly diagnosed diabetes mellitus. Group 2 had the highest number of patients (64.4%), followed by Group 3 (10.4%), Group 4 (4.3%), and Group 0 (4.1%). The highest average blood glucose values were found in Group 2 (258.00), followed by Group 3 (230.00), and Group 4 (237.00). Undiagnosed patients with diabetes mellitus risk can apply with complications, and this not only threatens the lives of these patients but also dramatically reduces their quality of their life. It should be considered that there could be diabetes mellitus patients, as well as stress hyperglycaemia patients, with a high blood sugar level, in the emergency department. Thus, we believe that patients diagnosed with a high blood sugar level should be advised to attend their family practices and/or a polyclinic for disease monitoring, with follow-up in an endocrine unit. © 2017, Scientific Publishers of India. All rights reserved.Öğe Irritant phytocontact dermatitis caused by buttercup at various times: A series of three patients(TIP ARASTIRMALARI DERNEGI, 2018) Benli, A.R.; Oruç, M.A.; Erturhan, S.; Sunay, D.Traditional herbal medicine is very common in the Anatolian regions and has been used for centuries. In this study, it was aimed to show the course of dermatitis in cases of phyto contact dermatitis caused by buttercups when the patients presented at different times after the application. 3 patients who lived in the same region presented at the family practice clinic because of lesions which emerged after the topical application of plants from the Ranunculaceae family for knee pain. The patients presented on the 1st, 4th and 15th day respectively after application and were all diagnosed with irritant phyto contact dermatitis. In Turkey, particularly amongst the elderly, the use of herbal treatments is greater than has been estimated. Therefore, when family practitioners observe lesions particularly on joint surfaces, the use of plant extracts must be questioned. © 2018, TIP ARASTIRMALARI DERNEGI. All rights reserved.Öğe Mean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux disease(E-Century Publishing Corporation, 2019) Sevencan, N.O.; Cesur, O.; Cakar, M.; Dogan, E.; Ozkan, A.E.; Benli, A.R.The aim of this study was to calculate the corrected rate of reflux in children with gastroesophageal reflux (GER)-like complaints by 24-hour pH monitoring and esophagogastroduodenoscopy (EGD), and to determine the utility of mean platelet volume (MPV) and red cell distribution width (RDW) as diagnostic biomarkers of GER disease (GERD) in children. The subjects in this prospective study were 109 children, 6 to 18 years old. Of them, 74 subjects were with GER symptoms and 35 healthy controls. The subjects were divided into three groups: those who underwent 24-hour pH monitoring (Group 1), those who underwent EGD together with pH monitoring (Group 2), and the healthy controls (Group 3). The results of pH monitoring and EGD and hematological parameters with controls were compared between Groups 1 and 2. In Groups 1 and 2, the overall rate of reflux was 40%, of esophagitis was 27.8%, and of Helicobacter pylori infection was 31.2%. The MPV and RDW cut-offs in subjects with reflux were ? 8.97 (sensi-tivity 89%, specificity 89%) and ? 12.78 (sensitivity 80%, specificity 97%), with an area under the Receiver Operating Characteristic (ROC) curve ± standard error (AUC ± SE) = 0.917 ± 0.027 (P < 0.001) and AUC ± SE = 0.866 ± 0.036 (P < 0.001), respectively. The endoscopic procedures are not practical due to being invasive and expensive. However, hemogram is a simple test which can be performed in an outpatient clinic. MPV and RDW calculated in hemogram could be easy, cost-effective, and high sensitive new biomarkers that can be used in children with GERD. © 2019, E-Century Publishing Corporation. All rights reserved.Öğe PREGNANCY CARE IN FAMILY MEDICINE: FROM A PAINFUL LYMPHADENOPATHY TO A RARE NON-HODGKIN’S LYMPHOMA CASE(Ankara Yildirim Beyazit University, 2020) Gökçek, B.; Aslaner, H.; Benli, A.R.A 32-year-old, 17-week pregnant patient visited her family physician because of painful lymphadenopathy on the right side of her neck after an upper respiratory tract infection. On physical examination, her vital signs were stable. A few elastic, firm, fixed, and painful lymphadenopathies, the largest of which was 1 cm were detected in the right cervical region, and the pharynx of the patient was hyperemic. Empirical antibiotherapy treatment was initiated by the family physician with the diagnosis of upper respiratory tract infection and the patient was called for control follow-up. Due to the rapid growth of lymph nodes and their size over 1 cm, she was referred to the otorhinolaryngology outpatient clinic with a preliminary diagnosis of malignancy. She was diagnosed with Diffuse Large B Cell Lymphoma. Pregnancy termination was recommended to the patient whose chemotherapy was scheduled, but the patient refused. At the 32nd week of pregnancy, the pregnancy was terminated due to fetal distress and a 1500-gram live baby girl was born. Since it is associated with pregnancy and rare, and that the family physician plays a role in early diagnosis of a important disease such as malignancy, it is deemed appropriate to present the case with literature. © 2020 Authors. All rights reserved.Öğe The prognostic role of platelet to lymphocyte ratio and mean platelet volume in critically ill patients(Verduci Editore s.r.l, 2018) Yildiz, A.; Yigit, A.; Benli, A.R.OBJECTIVE: The aim of this study was to identify the relationship between complete blood count parameters, mean platelet volume (MPV), and platelet to lymphocyte ratio (PLR) with mortality and hospitalization duration in critically ill patients. PATIENTS AND METHODS: A retrospective analysis was made of patients admitted to our tertiary adult intensive Care Unit (ICU) between January 2015 and January 2016. Hemoglobin (Hb), white blood cell (WBC), lymphocyte and platelet counts were obtained from the complete blood count performed at the time of admission. MPV and PLR levels were calculated from these data. Other data were retrieved from the patient follow-up records. RESULTS: The investigation included a total of 306 patients. The total mortality rate was 40.2%. The initial median PLR level was 206.7 (8.1-1675.0) for non-survivor patients and 194.5 (12.8-1236.6) for survivor patients. The PLR level was higher in the non-survivor group, but there was no statistically significant difference between the groups (p>0.05). The median MPV level was 7.66 (5.17-15.25) for the survivors and 8.09 (4.36-16.19) for the non-survivors, and there was no statistically significant difference between the groups (p=0.237). The median length of stay (LOS) of all patients was 7 (2-61) days. Only the Acute Physiology and Chronic Health Evaluation (APACHE) II score was found to have a positive correlation with LOS (p<0.05). CONCLUSIONS: PLR has no effect on mortality rates regardless of whether the patient has thrombocytopenia or not at the time of admission. MPV levels have no significant relationship with mortality. Neither MPV nor PLR have an effect on LOS. The use of these as a prognostic factor for mortality in critically ill patients is still unclear. © 2018 Verduci Editore. All rights reserved.Öğe Wet cupping therapy improves health related quality of life: A self-controlled interventional study(Ankara Yildirim Beyazit University, 2019) Ersoy, S.; Inci, H.; Sunay, D.; Kayis, S.A.; Engin, V.S.; Benli, A.R.Objectives: Wet cupping therapy is an ancient treatment method which has been an integral part of Traditional Anatolian Medicine. In the current study we aimed to assess the efficacy of wet cupping therapy on health-related quality of life in healthy volunteers. Materials and Methods: This was a single arm pre-test and post-test interventional study conducted in Traditional and Complementary Medicine Clinic of Karabuk Education and Research Hospital between August 1, 2017 and August 1, 2018. Fifty-three healthy volunteers were enrolled in the study. They received three wet cupping therapy sessions once every month for three months (On 0, 30, and 60 days). WHOQOL-BREF-TR questionnaire was applied to all participants both before the sessions and after the third one. Wilcoxon signed rank test was employed to compare pre and post test scores. A p value <0.05 assumed to be statistically significant. All analyzes were carried out using Minitab 17 Statistical Software. Results: The study sample consisted of 26 female and 27 male subjects. Mean age was 43.68 ± 9.41 years. It was found 46.34 ± 9.78 years for females and 40.63± 8.43 years for males. Initial WHOQOLBREF- TR scores regarding general health (p<0.001) and the four domains which were physical (p<0.001), psychological (p<0.001), social relations (p<0.001) and the environmental domain (p<0.005) showed significant improvements after three WCT sessions Conclusion: Our results suggest that quality of life may be improved in healthy adults by wet cupping therapy. © 2019 Ankara Yildirim Beyazit University. All rights reserved.Öğe What is the difference of effectiveness of wet cupping therapy in migraine types?(Scientific Publishers of India, 2017) Benli, A.R.; Oruç, M.A.Introduction: Wet-Cupping Therapy (WCT) is an ancient method used in several indications, particularly for incurable disorders such as migraine. The aim of this study was to investigate the impact of WCT on migraine. Materials and methods: The study included 78 patients diagnosed with migraine headache, and evaluations were made before and after WCT. Each patient underwent WCT three times at approximately 30 d intervals. The migraine disability assessment questionnaire for migraine and visual analog scale for pain severity were applied before treatment and after 90 d. Data were analysed with the Wilcoxon Signed Rank Test and Kruskal-Wallis Test using R software. Results: 62 of 78 patients completed the study. Patients were separated according to migraine types as migraine without aura (n=33, group I), aura (n=18, group II) and other (n=11, group III). Following WCT, a significant reduction was determined in all groups in the MIDAS and VAS scores. While the number of attacks significantly decreased in groups I and II, no significant improvement was determined in group III. Conclusion: The findings of this research indicate that WCT is effective on decreasing pain severity and attack number in migraine headache. © 2017, Scientific Publishers of India, All rights reserved.
