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    Aile hekimliği polikliniğine sporcu sağlık raporu için başvuran preeksitasyon sendromlu bir hasta: olgu sunumu
    (2018) Benli, Ali Ramazan; Cebecık, Ayla; Ersoy, Süleyman; Sunay, Didem
    Spora katılım öncesi muayene, aile hekimliği pratiğinde sorumluluğu artıran önemli bir durumdur. Sporda ani ölümlerin nedenlerinden birisi de kalpte ileti bozukluklarıdır. Wolf-Parkinson White sendromu elektrokardiyogramda kısa PR mesafesi ile karşımıza çıkan kısa PR sendromlarından biridir. Bu olguda aile hekimliği polikliniğinde spora katılım öncesi muayene için gelen, herhangi bir yakınması olmayan 14 yaşında kız çocuğunun çekilen EKG’ sinde kısa PR sendromu tespit edilmesi konu edilmiştir. Kardiyolojiye sevk edilen hastaya kardiyoloji tarafından ablasyon tedavisi uygulanmıştır. Bu olgu çerçevesinde aile hekimliğinde spora katılım öncesi muayene için başvuranlarda kardiyak değerlendirmenin önemini vurgulamak amaçlandı.
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    Assessment of thyroid function tests in patients with covid-19 infection and their relationship with euthyroid sick syndrome
    (2022) Aslaner, Hümeyra; Benli, Ali Ramazan; Çetin, Adil; Kaya Erten, Zeliha; Mıstık, Selçuk; Şimşek, Yasin
    Aim: Thyroid functions are affected by many factors functions such as some infections and drugs. This study aimed to investigate how the thyroid function tests were affected after COVID-19 infection and their relationship with euthyroid sick syndrome.Material and Method: Our study was designed as a retrospective and case-control study. The participants consisted of two groups as the control and patient groups. Thyroid function tests (TFT), hemogram and routine biochemistry of the groups were assessed. In addition, the tests of the patient group within the last 6 months before the infection were assessed. The patients’ symptoms, presence of a chronic disease, smoking history, and clinical status during COVID-19 infection were recorded.Results: A total of 473 people were included in the study. Of the participants, 54.5% were female. The white blood count (WBC), hemoglobin (HGB), platelet (PLT), and neutrophil (NEU) counts were higher in the patient group. Lymphocyte (LY) and mean platelet volume (MPV) counts were similar. Tyroid stimulating hormone (TSH) and triiodothyronine (T3) values of the patients were higher compared with the control group. The thyroxine (T4) level was similar in the two groups.TSH, T3 and T4 levels of the patient group before COVID-19 were higher than the results just after the quarantine process after COVID-19 infection.Conclusion: Thyroid dysfunction develops in COVID-19 patients within the course of the disease. This condition can be partially explained with the euthyroid sick syndrome. It is also possible with the thyroid gland being the direct or indirect target of the virus. 
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    B12 vitamin eksikliğinin etiyolojisinin araştirilmasi ve b12 vitamin düzeyi ile mcv, homosistein, folat düzeyleri ve tiroid fonksiyon testleri arasindaki ilişkinin saptanmasi
    (2018) Tuzcu, Mahmut Sami; Benli, Ali Ramazan; Kumbasar, Abdulbaki
    Amaç: DNA sentezinde rol alan B12 vitamini kan hücre olgunlaşması ve sinir sisteminin normal fonksiyonlarınıyapabilmesi için gereklidir (1). Bu çalışmada B12 vitamini eksikliği olan kişilerde etiyolojik etkenlerive B12 vitamin düzeyi ile MCV, homosistein, folat düzeyleri ve tiroid fonksiyon testleri arasındaki ilişkiyiaraştırdık.Gereç ve Yöntem: Temmuz 2009 - Eylül 2009 tarihinde Haseki Eğitim Araştırma Hastanesine başvuranhastalarda B12 vitamin düzeyi 189 (normal aralık) altında bulunan 115 hasta çalışmaya dahil edildi. Feeksikliği anemisi, talasemi, akut lökoz tanısı alan hastalar çalışmadan çıkarıldı. Hastalarda etiyolojik açıdanincelemek için yaş, alım eksikliği, emilimi bozacak ilaç kullanımı, kronik hastalık, cerrahi öykü sorgulandı.B12 vitamin düzeyi ile Htc, MCV, homosistein, folat düzeyleri ve tiroid fonksiyon testleri arasındaki ilişkiyiistatistiksel olarak değerlendirildi.Bulgular: Yaş grupları arasında B12 düzeyleri bakımından istatistiksel olarak anlamlı bir farklılık yoktu. 115hastadan 56’sında (%48,69) etiyolojik faktörlerden herhangi biri bulunamadı. Vitamin B12 eksikliğine nedenolan en sık proton pompa inhibitörü kullanımı ve alım eksikliği tespit edildi. Tiroid hormonları ile B12vitamin düzeyi arasında anlamlı bir ilişki bulunamaz iken homosistein değerleri arasında zayıf derecedeanlamlı negatif korelasyon saptandı.Sonuç: B12 vitamin eksikliği oluşturan en sık neden ilaç kullanımı ve alım eksikliği olarak tespit edildi. Hastaların%48.69’ unda etyolojik neden bulunamadı. B12 vitamin eksikliği halen tüm dünya da önemli bir sağlıksorunu olarak karşımıza çıkmaktadır. Bu nedenle yapılacak daha ileri araştırmalara ihtiyaç vardır.
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    Breast Masses in Adolescent Male
    (Derman Medical Publ, 2015) Cesur, Ozkan; Benli, Ali Ramazan
    Aim: The spectrum of breast lesions varies in children. Breast masses in adolescent male may arise from normal and abnormal breast development. Other causes of masses are infection, trauma, and cyst formation. Adolescent male patients present with a palpable mass is worrying for patient and his parents. In our study, we aimed to evaluate the characteristics of breast masses in adolescent males. Material and Method: We investigated 32 male pediatric patients presenting with breast masses from 2013 to 2014. Results: Thirty-two pediatric patients ranging in age from7-18 years were referred for breast ultrasound. Twenty-nine patients (%91) had gynecomastia. Two patients (%6) had post-traumatic hematoma. One patient(%3) had giant cystic mass (size 6x5x5cm) which excised. Discussion: Disorders of the adolescent breast are usually benign and their management are simple using medical strategy and mor rarely surgical therapy.
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    Calcium antagonists, digoxin, calcaemia and anaemia in heart failure.
    (Allied Acad, 2017) Yildiz, Sati Sena; Dikerdem, Didem; Benli, Ali Ramazan; Kalem, Pinar; Cikrikcioglu, Mehmet Ali
    Objective: To reveal that Calcium Antagonist (CA) use is associated with lower haemoglobin (Hb) and digoxin use is associated with higher Hb in Heart Failure (HF). Method: 223 chronic HF patients in acute decompensation phase were included in the study. Patients with comorbidities leading to anemia and those receiving blood transfusion or antianaemic treatment were excluded. Patients were classified into two groups as anemic and non-anemic groups. Two groups were compared retrospectively with demographics, clinical findings, medication use, echocardiography findings, complete blood count and biochemistry. Different independent variables between two groups were subjected to Multivariate Binary Logistic Regression Analysis (MBLRA) under the dependent variable anemia. Multivariable linear Regression Analysis (RA) was also performed with the dependent variable of Hb. Results: MBLRA results showed that anemia was seen less frequently in digoxin users, whereas it was more frequent in the following conditions: CA use, chronic renal failure, lower AST, lower LDL cholesterol, lower triglyceride, lower Transferring Saturation Rate (TSR). RA results also showed that lower LDL cholesterol, lower eGFR, lower transferrin saturation rate, lower corrected calcium, female gender and CA use were associated with lower Hb; whereas, digoxin use was associated with higher Hb. Conclusions: Haemoglobin levels were found higher in digoxin users. CA use, lower corrected calcium and lower AST were associated with lower Hb in heart failure. These findings have not been reported so far.
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    Candida glabrata Pneumonia in a Patient with Chronic Obstructive Pulmonary Disease
    (Hindawi Ltd, 2016) Yazici, Onur; Cortuk, Mustafa; Casim, Hasan; Cetinkaya, Erdogan; Mert, Ali; Benli, Ali Ramazan
    Pneumonia remains an important cause of morbidity and mortality among infectious diseases. Streptococcus pneumoniae and viruses are the most common cause of pneumonia. Candidiasis in such patients has been associated with haemodialysis, fungal colonization, exposure to broad-spectrum antibiotics, intensive care unit (ICU) hospitalization, and immunocompromised patients. The most common cause of infection is C. albicans. The case presented here is of a 66-year-old male patient diagnosed with C. glabrata. The patient suffered from chronic obstructive pulmonary disease.
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    Changing Efficacy of Wet Cupping Therapy in Migraine with Lunar Phase: A Self-Controlled Interventional Study
    (Int Scientific Information, Inc, 2017) Benli, Ali Ramazan; Sunay, Didem
    Background: The aim of this study was to evaluate the effect of blood-letting with wet cupping therapy (WCT) in migraine treatment and to determine whether there was any difference according to the phase of the moon when the treatment was applied. Material/Methods: This self-controlled study was conducted in Karabuk between 2014 and 2016. Patients who were diagnosed with migraine were enrolled in the study. Migraine disability assessment questionnaire (MIDAS), demographic characteristics, migraine attack frequency and duration, and family history was used to assess the severity of headache. WCT was applied in 3 sessions and the questionnaire was administered before and 3 months after the final WCT session. Wilcoxon signed-rank test was used in pre-and posttreatment measurements, and the Chi-square test was used to check independence in two-way categorical tables. Results: A total of 85 patients were included. The reduction in MIDAS scores and number of migraine attacks was significantly greater in the WCT applications made in the first half of the month compared to those in the second half of the month. Although the reduction in visual analog scale (VAS) scores was greater in the second half of the month, it was also significant in the applications made in the first half of the month. Conclusions: WCT was found to be an effective treatment of migraine. The effect on MIDAS, VAS, and the number of attacks was significantly better when the application was made in the second half of the month compared to those made in the first half.
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    Çocukluk çağı apandisit olgularında laboratuvar testlerinin analizi
    (2016) Cesur, Özkan; Benli, Ali Ramazan; Koyuncu, Murat
    Amaç: Bu çalışmada akut ve perfore apandisit olgularında tanısal metotların değerinin analiz edilmesi amaçlandı. Yöntem: Ocak 2013 - Aralık 2013 tarihleri arasında Karabük Üniversitesi (KBÜ) Karabük Eğitim ve Araştırma Hastanesi Çocuk Cerrahi servisine apandisit şüphesi ile yatırılan ve apendektomi yapılan 97 hastanın dosyaları retrospektif incelendi. Demografik verileri, laboratuvar ve histopatolojik sonuçları değerlendirildi. Veriler SPSS 12.0 programında analiz edildi. Bulgular: Hastaların yaş ortalaması 11±3.36 idi. K/E oranı 1/1.4 olarak saptanmıştır. Histopatolojik incelemede hastaların %37.2'si (n=36) akut fokal apandisit, %34.1'i (n=33) süpüratif apandisit, %17.8'i (n=17) gangrenöz-perfore apandisit, %9.8'i (n=10) lenfoid hiperplazi, %1.1'i (n=1) kronik apandisit olarak tanımlanmıştır. Süpüratif ve gangrenöz-perfore form apandisitlerde diğer tiplere göre total lökosit sayısı (WBC), nötrofil oranı (NR) ve C-reaktif protein (CRP) değerleri istatistiksel olarak anlamlı yüksek bulunmuştur (p<0.05). Hastaların laboratuvar incelemeleri sonucunda WBC sayısı, NR ve CRP'nin duyarlılık, özgüllük, pozitif tanımlama, negatif tanımlama ve doğruluk oranları belirlenmiştir. Bu oranlar sırasıyla WBC için %65, %60, %96, %92 %65, NR için %55, %60, %96, %94 %56 ve CRP için %50, %80, %92, %98 %52 olarak bulunmuştur. WBC sayısı, NR ve CRP bir arada değerlendirildiğinde ise%84, %60, %97, %84 %83 olarak anlamlı düzeyde yüksek bulunmuştur. Sonuç: Total lökosit sayısı düzeylerinde anlamlı artışın tanısal kesinliği artırmadığı ancak komplike apandisit olguları ilgili olabileceği görüldü. WBC, NR ve CRP'nin ayrı ayrı bağımsız belirleyiciler olmadığı gibi seçiciliklerinin de yeterli olmadığı tespit edildi. Sonuç olarak; WBC düzeyi, NR ve CRP'nin birlikte değerlendirilmesinin komplike apandisit olgularına yaklaşımda daha faydalı olacağı düşünülmektedir
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    Comparison of alternative nutrition practices in intensive care patients in terms of mortality and malnutrition
    (2019) Atayan, Yahya; Ertınmaz Özkan, Ayşegül; Aksakal, Gökhan; Benli, Ali Ramazan; Özkan Sevencan, Nurhayat; Erdoğan, Mehmet Ali
    It is important to ensure proper nutrition to prevent malnutrition, mortality and the development of metabolic disorders in followed up patients in the intensive care unit. In case the patients gastrointestinal tract starts functioning, enteral feeding should be started in the early period. Patients should be given parenteral support when the gastrointestinal tract does not work. In this study, we compared the mortality, malnutrition and metabolic parameters of patients who received nutritional support via nasogastric catheter, percutaneous endoscopic gastrostomy and total parenteral nutrition. We retrospectively analyzed 117 patients’ data with no oral intake in the intensive care unit. Patients were divided into 3 groups according to nutritional practices. Group 1included 62 patients with PEG, group 2 included 28 patients with NG and group 3 had 27 patients with TPN support. In the comparison of mortality between groups, there was a significant decrease in PEG fed patients (p <0.001). There was also a significant decrease in mortality of NG group when compared to TPN group (p<0.01, Table2). In malnutrition comparison, serum albumin levels were significantly higher in PEG fed patients than in other groups (Table 3, p <0.03). There were significant improvements in metabolic parameters in the PEG group patients. We suggest that nutritional support should be provided to serious patients in intensive care unit as soon as possible in order to reduce morbidity, mortality and malnutrition, and we think that PEG procedure is safer and more effective nutritional practice than other procedures.
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    A comparison of the efficacy of varenicline and bupropion and an evaluation of the effect of the medications in the context of the smoking cessation programme
    (European Publishing, 2017) Benli, Ali Ramazan; Erturhan, Selman; Oruc, Muhammet Ali; Kalpakci, Pinar; Sunay, Didem; Demirel, Yeltekin
    Background: Within the context of the support program for smoking cessation, initiated by the Turkish Ministry of Health in 2011, those who present at 'smoking cessation' centres and are found to be suitable for pharmacological treatment are given varenicline and bupropion free of charge. As the smoking cessation programme is centralized, the selection of the medication is made randomly to provide a fixed distribution rate. The aim of this study was to evaluate the efficacy of both varenicline and bupropion in smoking cessation and to evaluate the effect of the smoking cessation programme. Methods: A total of 405 individuals who met the study criteria were included in the study. Smoking habits and degree of dependence were determined in all the participants with the Fagerstrom test for nicotine dependence (FTND) and bupropion or varenicline therapy was initiated in those who were eligible. Patients were followed up at 15 days then at 1, 2, 3, 6 and 12 months after smoking cessation. A level of CO < 5 ppm and 'point prevalence abstinence' were used as the criteria of success for smoking cessation and this evaluation showed the non-smoking status in the previous 7 days. Results: The mean age of the participants was 35.19 +/- 7.73 years and 82.8% (n = 334) were male. Of the participants, 60.2% (n = 244) were given varenicline and 39.8% (n = 161) bupropion. The mean FTND and package/year was not significantly different between the groups. The rates of success in the 1st and 2nd weeks, and 1st, 3rd and 6th months were significantly higher in the varenicline group than in the bupropion group (p < 0.05). At the end of one year, the rate of smoking cessation was determined as 13.9% (n = 34) in the varenicline group and 6.2% (n = 10) in the bupropion gruop. The difference was statistically significant (p = 0.015). At the end of 1 year when the previous 7 days smoking status was evaluated with the 'point prevalence abstinence' measurement as the success criteria, success rates were 20.5% with varenicline and 18.6% with bupropion and the difference was not significant (p = 0.646). The individuals who used the medications for 45 days or longer were more successful in smoking cessation (p < 0.001). The most common reasons given for discontinuing the medication were the side-effects (31.5%). No significant difference was determined between the groups in respect of the side-effects observed. Conclusions: Although the rates of smoking cessation in all the other control points were higher with varenicline than with bupropion, no significant difference was found between the success rates of varenicline and bupropion used in smoking cessation based on the last 7 days at the end of one year. Those who used the medications for 45 days or longer were more successful in smoking cessation.
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    Comparison of the Number and Reasons of Death in the First Five Months of 2020 in Kayseri with the Previous Year
    (Duzce Univ, Fac Medicine, 2021) Gokcek, Mebrure Beyza; Aslaner, Humeyra; Cetin, Adil; Gokcek, Irfan; Benli, Ali Ramazan
    Objective: The spread of a new contagious disease across the world is called a pandemic. COVID-19 was declared as a pandemic by WHO on 11th March 2020. Although treatment modalities and vaccines are being developed against COVID-19 disease, COVID-19 related deaths continue and the rate of infectious diseases among all causes of death increases. In this study, we aimed to determine the effect of COVID-19 infection on mortality statistics by comparing mortality statistics in the first five months of 2020 with mortality statistics in the same period of 2019. Methods: This study was conducted by evaluating the death notification system data records using the ICD 10 diagnostic coding system for the first five months of 2019-2020 of the Kayseri Provincial Health Directorate, between 1 June 2020 and 1 July 2020. It is a retrospective study. In the study, data on dates (months) of deaths, ages, genders, marital statuses, causes of death and manners of death (infectious disease, forensic, natural death) in Kayseri were evaluated. Data were evaluated in SPSS (version 21.0) statistical package program. Results: There were 3349 deaths in the first 5 months of 2019, and 3491 deaths in the first five months of 2020. Of these, 54.6% were male and 45.4% were female. The monthly average numbers of death in 2019 and 2020 were similar. The rates of disease diagnoses differed in 2019 and 2020. In 2020, all-cause death numbers, including COVID-19, were higher among men. The total mortality rate of infectious diseases was 20.2% in 2019, and the mortality rate due to infectious diseases including COVID-19 was 20.1% in 2020. Conclusions: During the COVID-19 outbreak, there were significant changes in the rates of some specific causes of death. However, there was no significant change in the total number of deaths during the first five months in Kayseri province.
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    A complication of wet cupping therapy: vesiculobullous plaque on an erythematous base
    (Elsevier, 2017) Benli, Ali Ramazan; Aktas, Habibullah
    [No abstract available]
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    Continue or stop applying wet cupping therapy (al-hijamah) in migraine headache:A randomized controlled trial
    (Elsevier Sci Ltd, 2020) Ersoy, Suleyman; Benli, Ali Ramazan
    Background: and purpose: Although wet cupping therapy (WCT) is currently in use, clinical investigations of its efficiency are scarce. The aim of this study was to evaluate the short- and long-term effects of WCT on headache and disability associated with migraine. Materials and methods: This was an open-label trial conducted at Karabuk University Training and Research Hospital between May 2016 and January 2018. WCT was applied once a month to migraine patients. At the end of 3 months, patients were randomized into two groups using block randomization method. Control group (Group 1) consisted of 53 patients and the intervention group (Group 2) 56 patients. Evaluation was performed to both groups before treatment and at the 6th and 12th months using the migraine disability assessment (MIDAS). Results: Group 1 received three sessions, whereas Group 2 continued treatment for 12 months. Visual analog scale (VAS) and MIDAS values at the 12th month were significantly higher compared with 6-month values in Group 1 (p < 0.001) and lower in Group 2 (p < 0.001). Both VAS and MIDAS scores of the patients in Group 2 improved significantly better than those in Group 1. No adverse effects were seen. Conclusion: WCT reduced pain and disability in patients with migraine, and the efficacy increased when the application was continued.
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    Does bullous erythema ab igne develop easier in diabetics? A case series of four patients
    (2017) Benli, Ali Ramazan; Aydın, Ersin; Aktaş, Habibullah; An, İsa
    Eritema ab igne kronik ısı maruziyetinin meydana getirdiği bir deri hastalığıdır. Özellikle alt ekstremitelerde subjektif belirtileri de olabilen ağ benzeri eritem ve pigmentasyonla kendini belli eder. Eritema ab igne malign potansiyeli nedeniyle önem taşır. Büllöz lezyonların eşlik ettiği eritem ab igne çok nadirdir ve şimdiye kadar diabetle ilişkisinden bahsedilmemiştir. Bu makalede büllöz eritema ab igne tanısı konulan dört diabetik hastayı sunuyor ve özellikle diabetik hastalarda kronik ısı maruziyetinin sakıncalarına vurgu yapıyoruz.
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    The effect of blood groups on infection and prognosis of sarscov-2
    (2021) Aslaner, Hümeyra; Gökçek, Mebrure Beyza; Benli, Ali Ramazan; Baydemir, Recep; Akyol, Gülsah; Güven, Zeynep Tugba; Kaynar, Leylagül
    Aim: This study aimed to investigate the effect of blood groups on the risk and prognosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the infected/source cases and contact individuals. Material and Method: This study was designed as a descriptive and retrospective study. The individuals who were in contact with the SARS-CoV-2main/source cases and followed at home were included in the study.The distribution of the participants according to their blood groups was assessed. Patients were divided into three groups as group 1 including source/main cases, group 2 including SARSCoV-2contacts who were living in the same house with the source case and followed up, and group 3 including contacts who were followed up in the same house but did not develop SARS-CoV-2 during the follow-up. Results: While the rate of Non-O blood group was the highest (n=365, 39.4%) in group 2the rate of O blood group was the highest (n=190, 42.8%) in group 3 (p:0.028). While the rate of Rh positive blood group was high in group 1 that of Rh negative blood group was higher in group 3 (p:0.000). For other variables, the presence of a chronic disease was more in group 1 (p:0.000). Rh (+) blood group (OR:0.464, p:0.010, %95 Cl: 0.306 ~ 0.703) was among the factors affecting the development of the infection. Conclusion: Patients infected with SARS-CoV-2 mostly had A, Non-O blood group and Rh positivity. Having Rh (+) blood group may have increased the rate of infection development in high-risk household contacts. After patients in this blood group were detected as contacts a closer follow-up may be necessary to decrease morbidity.
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    The effect of ferritin, vitamin B12 and folic acid on pregnancy outcomes
    (E-Century Publishing Corp, 2016) Kalem, Pinar; Benli, Ali Ramazan; Koroglu, Mustafa; Benli, Neriman Cetin; Koyuncu, Murat; Cesur, Ozkan; Dane, Pakizer Banu Kilicoglu
    Purpose: A reduction occurs in levels of some minerals and vitamins due to physiological adaptation during pregnancy, and this situation causes anemia in pregnancy. The aim of the present study was to evaluate the effect of ferritin, vitamin B12 and folate levels on outcomes of pregnancy in 3rd trimester pregnant women. Materials and Methods: This retrospective study included a total of 72 pregnant women in the third trimester of pregnancy. Vitamin and mineral analyses of the patients were applied. Patients were questioned in respect of whether or not iron and vitamin supplements were taken during pregnancy, the mode of delivery and the history of postpartum problems in infant. Results: As the number of children increased, so an increase was seen in the incidence of anemia. Of the mothers of newborns with medical problems, 60% had anemia. There was no statistically significant difference in the mean birth weight according to the presence or absence of maternal anemia. Anemia in pregnant women is defined as hemoglobin level below 11.0 g/dL in the first and third trimester and below 10.5 g/dL in the second trimester. No significant difference was determined in anemia status according to the mode of delivery. No difference in anemia was detected in infants, regardless of whether or not their mothers took vitamin and mineral supplements. Conclusion: Anemia in the third trimester has no effect on the mode or time of delivery, weight and general condition of the newborn. To decide the effect of anemia on the outcome of pregnancy, further studies with more participants are needed.
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    The Effect of Hormone Replacement Therapy on Postmenopausal Sternoclavicular Joint Arthritis
    (Derman Medical Publ, 2017) Mutlu, Sibel; Mutlu, Tansel; Benli, Ali Ramazan; Sunay, Didem
    Aim: To investigate the effect of hormone replacement therapy on the treatment of postmenopausal sternoclavicular joint (SCJ) arthritis. Material and Method: This cross-sectional study included postmenopausal female patients who presented with complaints of pain and swelling in the SCJ at the Orthopaedics Polyclinic of Karabuk University Training and Research Hospital between September 2014 and September 2016. After the imaging and laboratory tests required for evaluation by an orthopaedic specialist, the patients were referred to the Gynaecology Department for evaluation in respect of postmenopausal symptoms and hormone replacement therapy (HRT). For those with indications, HRT was started. The treatment protocol for SCJ arthritis was applied to all patients by the orthopaedics specialist. The patients were separated into two groups: those receiving HRT (Group 1) and those not receiving HRT (Group 2). The sociodemographic and clinical characteristics and laboratory test results were recorded for all patients. All the patients were evaluated by the orthopaedic specialist at the 1st, 3rd, 6th, and 12th month of treatment using the Rockwood Scale (RS) and the Visual Analog Scale (VAS) for pain. Results: A total of 92 patients met the study criteria and were included for evaluation. As 13 patients did not attend follow-up examinations, they were excluded and the study was completed with 79 patients. Group 1 comprised 38 patients who started HRT on the recommendation of the Gynaecology Department and Group 2 comprised 41 patients who were not taking HRT. The mean age of patients was 52.6 +/- 5.2 years in Group 1 and 54.1 +/- 4.8 years in Group 2. No statistically significant difference was determined between the groups in respect of age, imaging, and laboratory test results (p>0.05). The need for non-steroid anti-inflammatory drugs and intraarticular injection was statistically significantly lower in Group 1 compared to Group 2 (p=0.012, p=0.006 respectively). No difference was determined between the groups in respect of the VAS scores evaluated preoperatively and at 1 month of treatment (p=0.712, p=0.579, respectively). In Group 1, the VAS scores at 3 months (p=0.038), 6 months (p=0.0213), and 9 months (p<0.001) were determined to be statistically significantly lower than those of Group 2. The RS values of both groups were similar preoperatively and at 1 month (p=0.897, p=0.789, respectively), while the results of Group 1 were statistically significantly higher at 3 months (p=0.034), 6 months (p=0.0212), and 9 months (p=0.0392). At the end of 1 year, the results of both VAS and RS were similar in the two groups (p=0.676, p=0.867, respectively). Discussion: The results of this study showed that with the application of HRT when there were indications, postmenopausal SCJ arthritis was less symptomatic, improved in a shorter time, and required fewer tests and less medication.
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    Effect of positive airway pressure treatment on the life quality of patients with sleep apnea syndrome
    (2016) Kıraz, Kemal; Çörtük, Mustafa; Zıtounı, Burcak; Çetinkaya, Erdem Atalay; Benli, Ali Ramazan
    Objectives: Sleep apnea syndrome (OSA) is closely associated with obesity and cardiovascular diseases.OSA disrupts neurocognitive functioning and negatively affects quality of life. Use of a positive airwaypressure (PAP) device remains the gold standard treatment for OSA. We used the Short Form?36 (SF?36)instrument to measure quality?of?life changes in PAP?treated patients in Turkey.Materials and Methods: The present study included 67 (52 male) consecutive OSA patients treated witha PAP device. Each subject underwent overnight full?laboratory polysomnographic examination. The SF?36 scores of patients given a PAP device were measured before they commenced using the device and 6–18months later. Results: Appropriate use of PAP devices improved quality of life as evidenced by improvement on allparameters of the SF?36 instrument quality?of?life scale (P<0.05). Conclusion: We found that PAP therapy significantly improved quality of life. This study is the first inTurkey to use the SF?36 on this subject.
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    The Effect of Wet Cupping Therapy on Heavy Metal Levels: A Single-Arm Clinical Trial
    (Kowsar Publ, 2020) Benli, Ali Ramazan; Ersoy, Suleyman
    Objectives: In this study on the steelworkers, we aimed to investigate the impact of wet cupping therapy (WCT) on heavy metal levels in the blood. Methods: This single-arm clinical trial was performed at Karabuk University Training and Research Hospital from January to August 2018. All patients received three WCT sessions once every month. Venous blood specimens were drawn prior to the first WCT session (venous 1) and following the third session (venous 2). Cupping blood samples were also obtained during the first session of WCT. Heavy metal levels were assessed by inductively coupled plasma mass spectrometry (ICP-MS) device. Thirteen metals were subject to examination: aluminum (Al), antimony (Sb), arsenic (As), cadmium (Cd), chrome (Cr), cupper (Cu), iron (Fe), lead (Pb), manganese (Mn), mercury (Hg), molybdenum (Mo), nickel (Ni), and zinc (Zn). Relationships between the blood samples were examined using Wilcoxon Signed Rank test by R statistical software. Results: Forty-four subjects completed the study. The levels of Al, Cd, Cr, Cu, Mn, Mo, Ni, Sb (P < 0.001 in all), Hg (P = 0.024) and Pb (P = 0.012) were significantly lower in venous 2 samples compared to venous 1, while no significant changes were observed in the levels of Fe, Zn, and As (P = 0.575, P = 0.090 and P = 0.195, respectively). When compared to venous 1 the levels of Mn, Zn, As, Sb, Hg (P < 0.001 in all), Al (P = 0.003), Cr (P = 0.004), Cu (P = 0.022) andMo(P = 0.014) were found significantly higher in cupping blood while Cd, Pb, and Ni were not at significantly different levels (P = 0.160, P = 0.079 and P = 0.713, respectively). Fe was found significantly lower in cupping blood (P < 0.001). Conclusions: This study showed that WCT has significantly reduced heavy metal levels in the blood. It might be useful in workers who work in jobs where heavy metal toxicity can be seen.