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    THE DIRECT COST COMPONENTS IN HEART FAILURE WITH REDUCED EJECTION FRACTION (HF-REF) IN TURKEY: THE RESULTS OF A DELPHI PANEL
    (Elsevier Science Inc, 2016) Aras, D.; Aydogdu, S.; Bozkurt, E.; Cavusoglu, Y.; Eren, M.; Erol, E.; Gulec, S.
    [No abstract available]
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    Potential anti-tumor activity of kefir-induced juglone and resveratrol fractions against ehrlich ascites carcinoma-bearing balb/c mice
    (Iranian Journal of Pharmaceutical Research, 2020) Bozkurt, E.; Atay, E.; Pektas, G.; Ertekin, A.; Vurmaz, A.; Korkmaz, Ö.A.; Sadi, G.
    We investigated the potential influence of kefir-induced juglone and resveratrol fractions (JRK) against Ehrlich Ascites Carcinoma (EAC) bearing BALB/c male mice. Kefir yeast was grown in the cell culture supplemented with juglone and resveratrol (1:2). After 48 h incubation, JRK solution was applied (0.1 mL/day i.p.) to the EAC-bearing mice throughout five days. Molecular regulatory mechanisms of apoptotic and anti-apoptotic pathway components were evaluated in the plasma of mice and isolated EAC cells with ELISA, qRT-PCR, and immunocytchemical experiments. EAC-induced upregulation in Bcl-2 and downregulation in Caspase-3 were normalized with JRK in the plasma of mice. Additionally, JRK upregulated the expression levels of apoptotic Bax, p53, Caspase-3,8,9, and APAF-1 proteins together with BAX, CASPASE-8, and CASPASE-9 genes in isolated EAC cells. These changes were also associated with decreased expression levels of anti-apoptotic Bcl-2 and Bcl-xl proteins. Immunocytochemical studies also confirmed the activation of apoptotic pathways and repression of anti-apoptotic proteins in EAC cells with JRK treatment. JRK activates apoptotic pathway and inhibits anti-apoptotic genes and proteins in Ehrlich ascites carcinoma-bearing BALB/c mice that could be beneficial in cancer treatment. © 2020, Iranian Journal of Pharmaceutical Research. All rights reserved.