Yazar "Cengiz, Mustafa" seçeneğine göre listele

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    Blood and Stool Arsenic Levels Are Decisive for Diagnosing Children's Functional Gastrointestinal Disease (FGD)
    (Springernature, 2022) Bilici, Namik; Dogan, Erkan; Sevinc, Eylem; Sevinc, Nergiz; Akinci, Gulsema; Musmul, Ahmet; Cengiz, Mustafa
    Pediatric gastroenteritis is a potentially fatal disease that accounts for 10% of childhood deaths. The main risk is environmental factors and nutrition. Arsenic (As) is commonly found in the earth's crust. As is an essential element that can form many organic compounds. In children, it causes diarrhea, gums, tongue lesions, diabetes, conjunctivitis, ocular opacity, and impaired immune response. It also causes low growth, mental retardation, and neurological problems. It is also known as the cause of many cancers that originate at an early age. Regionally, there is an iron and steel industry for almost a century. According to the Rome IV criteria, the blood and stools of 50 children aged 6-18 years, male and female, living in our province with functional gastrointestinal disease (FGD), were screened for As, and compared with the Healthy group (control) of 30 children. The results were evaluated with the Mann-Whitney Rank Sum Test. When blood and stool As values in males were compared with control samples, a high level of significance (p = 0.001) was found between both blood and stool As values in sick males and the control group (p < 0.005). In females, blood and stool As median values were also highly significant when compared with the control group (p = 0.001). According to these data, when the sick children (children with male and female gender) are compared with the healthy ones, the difference is highly significant (p < 0.005). High blood As levels in children indicate environmental pollution. It can be said that blood As levels are high as a result of food, water, and inhaler exposure. The presence of a high level of significant difference in stool means that the amount of As is high in the foods consumed daily. High levels of As are in blood and stools; It was evaluated that FGD could be the cause of nausea, diarrhea, vomiting, and colic. The increase in blood and stool As values due to environmental pollution is an important reason for FGD. For diseases of uncertain cause (such as FGD) resulting from chronic As exposure, blood and especially stool As values are more significant than urinary As levels. In conclusion, As a diagnostic criterion, it was concluded that blood and stool As values are an important marker in children with functional abdominal pain with other metals.
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    Cyclophosphamide induced oxidative stress, lipid per oxidation, apoptosis and histopathological changes in rats: Protective role of boron
    (Elsevier Gmbh, 2020) Cengiz, Mustafa; Sahinturk, Varol; Yildiz, Songul Cetik; Sahin, Ilknur Kulcanay; Bilici, Namik; Yaman, Suzan Onur; Altuner, Yilmaz
    Background: Cyclophosphamide (CP) is an alkylating chemotherapeutic drug used in the treatment of many types of cancer. However, as with other chemotherapeutic drugs, the use of CP is limited by the damage to healthy tissues such as testes, bladder and liver as well as cancerous tissue. Boron (B) is a trace element with many biological properties such as antioxidant, anti-apoptotic and anti-lipid per oxidation. Methods: This current study aims to determine protective effects of B on CP induced testicular toxicity. The rats were divided into 4 groups (control, CP, B and B plus CP groups). The testes of experimental animals were taken for histological, apoptotic markers and biochemical analysis. Results: The damage to some seminifer tubules, loss of typical appearance, thinning of seminifer epithelium and relative enlargement of the tubule lumen were watched in testis of the group that administrated CP. Moreover, Bcl-2, TAC and GSH levels decreased while TOC, OSI, MDA, Bax and Caspase-3 levels increased. On the other hand, pretreatment limited to B in the B plus CP group, testicular tissue improved. In addition, Bcl-2, GSH, TAC levels increased, Bax, MDA, TOC, OSI and caspase-3 levels decreased. Conclusion: B significantly reduced testicular lipid per-oxidation and strengthened antioxidant defenses. Our results showed that pre-treatment B can protect rat testis against CP-induced testicular damage owing to its anti-lipid per oxidation, anti-oxidant and anti-apoptotic properties.
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    The use of family planning methods by Somali women between the ages of 15-49 living in Turkey and their plans and attitudes towards these methods
    (2024) Aweis, Saida Abukar; Bilici, Namık; Cengiz, Mustafa; Ertekin, Rıfat; Ayhancı, Adnan
    Family planning (FP): individuals consciously plan the birth interval and regulate its timing. For FP, this effort requires resources such as drugs and devices and specific methods. This scientific research investigated the use of FP methods by Somali women aged 15-49 living in Turkey. Women were interviewed face to-face in 15 provinces with a survey consisting of 60 questions. According to the results of our scientific research, Somali women's cultures, traditions, social lifestyles, incomes, and religious beliefs have changed the use of FP methods at different levels. The pregnancy rate at a child age (<18) is 20%. 1/3 of women do not use any FP method. Belief, tradition, culture, tribe and family pressure are the biggest obstacles to FP. Income status changes the level of FP. As a result, proper planning of education and organized health delivery can reduce Somali women's FP approach and, therefore, obstetric problems. Aile planlaması (FP); bireylerin doğum aralığını planlamak ve zamanlamasını düzenlemek üzere bilinçli çaba göstermeleridir. FP için bu çaba ilaç ve cihaz gibi kaynaklara ve belirli yöntemlere ihtiyaç duyar. Bu bilimsel araştırmada Türkiye'de yaşayan 15-49 yaş arası Somalili kadınların FP yöntemlerini kullanımları araştırıldı. 60 sorudan oluşan bir anket ile 15 vilayette kadınlarla yüz yüze görüşüldü. Bilimsel araştırmamızın sonuçlarına göre, Somalili kadınların kültürleri, gelenekleri, sosyal yaşam tarzları, gelirleri ve dini inançları değişik düzeylerde FP yöntemlerinin kullanımını değiştirmektedir. Çocuk yaşta (<18) gebelik oranı %20 düzeyindedir. Kadınların 1/3'ü hiçbir FP yöntemini kullanmamaktadır. İnanç, gelenek, kültür, kabile ve aile baskısı FP'nin önündeki en büyük engellerdir. Gelir durumu FP düzeyini değiştirmektedir. Sonuç olarak eğiti