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    The effect of ferritin, vitamin B12 and folic acid on pregnancy outcomes
    (E-Century Publishing Corporation, 2016) Kalem, P.; Benli, A.R.; Koroglu, M.; Benli, N.C.; Koyuncu, M.; Cesur, O.; Dane, P.B.K.
    Purpose: A reduction occurs in levels of some minerals and vitamins due to physiological adaptation during pregnancy, and this situation causes anemia in pregnancy. The aim of the present study was to evaluate the effect of ferritin, vitamin B12 and folate levels on outcomes of pregnancy in 3rd trimester pregnant women. Materials and Methods: This retrospective study included a total of 72 pregnant women in the third trimester of pregnancy. Vitamin and mineral analyses of the patients were applied. Patients were questioned in respect of whether or not iron and vitamin supplements were taken during pregnancy, the mode of delivery and the history of postpartum problems in infant. Results: As the number of children increased, so an increase was seen in the incidence of anemia. Of the mothers of newborns with medical problems, 60% had anemia. There was no statistically significant difference in the mean birth weight according to the presence or absence of maternal anemia. Anemia in pregnant women is defined as hemoglobin level below 11.0 g/dL in the first and third trimester and below 10.5 g/dL in the second trimester. No significant difference was determined in anemia status according to the mode of delivery. No difference in anemia was detected in infants, regardless of whether or not their mothers took vitamin and mineral supplements. Conclusion: Anemia in the third trimester has no effect on the mode or time of delivery, weight and general condition of the newborn. To decide the effect of anemia on the outcome of pregnancy, further studies with more participants are needed. © 2016, E-Century Publishing Corporation. All rights reserved.
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    Mean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux disease
    (E-Century Publishing Corporation, 2019) Sevencan, N.O.; Cesur, O.; Cakar, M.; Dogan, E.; Ozkan, A.E.; Benli, A.R.
    The aim of this study was to calculate the corrected rate of reflux in children with gastroesophageal reflux (GER)-like complaints by 24-hour pH monitoring and esophagogastroduodenoscopy (EGD), and to determine the utility of mean platelet volume (MPV) and red cell distribution width (RDW) as diagnostic biomarkers of GER disease (GERD) in children. The subjects in this prospective study were 109 children, 6 to 18 years old. Of them, 74 subjects were with GER symptoms and 35 healthy controls. The subjects were divided into three groups: those who underwent 24-hour pH monitoring (Group 1), those who underwent EGD together with pH monitoring (Group 2), and the healthy controls (Group 3). The results of pH monitoring and EGD and hematological parameters with controls were compared between Groups 1 and 2. In Groups 1 and 2, the overall rate of reflux was 40%, of esophagitis was 27.8%, and of Helicobacter pylori infection was 31.2%. The MPV and RDW cut-offs in subjects with reflux were ? 8.97 (sensi-tivity 89%, specificity 89%) and ? 12.78 (sensitivity 80%, specificity 97%), with an area under the Receiver Operating Characteristic (ROC) curve ± standard error (AUC ± SE) = 0.917 ± 0.027 (P < 0.001) and AUC ± SE = 0.866 ± 0.036 (P < 0.001), respectively. The endoscopic procedures are not practical due to being invasive and expensive. However, hemogram is a simple test which can be performed in an outpatient clinic. MPV and RDW calculated in hemogram could be easy, cost-effective, and high sensitive new biomarkers that can be used in children with GERD. © 2019, E-Century Publishing Corporation. All rights reserved.