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    Calcium antagonists, digoxin, calcaemia and anaemia in heart failure.
    (Allied Acad, 2017) Yildiz, Sati Sena; Dikerdem, Didem; Benli, Ali Ramazan; Kalem, Pinar; Cikrikcioglu, Mehmet Ali
    Objective: To reveal that Calcium Antagonist (CA) use is associated with lower haemoglobin (Hb) and digoxin use is associated with higher Hb in Heart Failure (HF). Method: 223 chronic HF patients in acute decompensation phase were included in the study. Patients with comorbidities leading to anemia and those receiving blood transfusion or antianaemic treatment were excluded. Patients were classified into two groups as anemic and non-anemic groups. Two groups were compared retrospectively with demographics, clinical findings, medication use, echocardiography findings, complete blood count and biochemistry. Different independent variables between two groups were subjected to Multivariate Binary Logistic Regression Analysis (MBLRA) under the dependent variable anemia. Multivariable linear Regression Analysis (RA) was also performed with the dependent variable of Hb. Results: MBLRA results showed that anemia was seen less frequently in digoxin users, whereas it was more frequent in the following conditions: CA use, chronic renal failure, lower AST, lower LDL cholesterol, lower triglyceride, lower Transferring Saturation Rate (TSR). RA results also showed that lower LDL cholesterol, lower eGFR, lower transferrin saturation rate, lower corrected calcium, female gender and CA use were associated with lower Hb; whereas, digoxin use was associated with higher Hb. Conclusions: Haemoglobin levels were found higher in digoxin users. CA use, lower corrected calcium and lower AST were associated with lower Hb in heart failure. These findings have not been reported so far.
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    An evaluation of thyroid autoimmunity in patients with beta thalassemia minor: A case-control study
    (Professional Medical Publications, 2017) Benli, Ali Ramazan; Yildiz, Sati Sena; Cikrikcioglu, Mehmet Ali
    Objective: The tendency to autoimmune diseases has been reported to be increased in beta thalassemia minor (BTM). The aim of this study was to evaluate whether thyroid autoimmunity is higher in BTM. Methods: Patients with BTM (n= 86) and a healthy control group (n= 93) were included in this cross- sectional casecontrol study. The two groups were compared in terms of anti-thyroglobulin (anti-TG) and anti-thyroid peroxidase (anti-TPO) and thyroid hormones. Results: In the BTM group, thyroid hormones and serum anti-TG and anti-TPO antibody levels were not statistically different from those of the control group. The BTM and control groups were similar in terms of anti-thyroid antibody (ATA) positivity prevalence. In the BTM group, anti-TG was 11.6% and anti-TPO was 14% positive, while these values were 14% and 12.9% positive, respectively in the control group (p=0.806 and p=0.989, respectively). The proportion of anti-TG and/or anti-TPO antibody positive subjects was found to be 20.9% in the BTM group, and 20.4% in the control group (p=0.919). The ratios of subjects with euthyroidism, hyperthyroidism and hypothyroidism were similar in both groups. Conclusions: As the thyroid autoimmunity prevalence in the BTM group was not increased compared to the control group, it can be considered that there is no necessity for routine ATA and thyroid hormone testing in subjects with BTM.