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Öğe THE IMPORTANCE OF ANTIOXIDANT STATUS IN GASTRIC INTESTINAL METAPLASIA(Soc Medical Biochemists Serbia, 2021) Danis, Nilay; Ozkan, Aysegul; Karatas, Fatih; Cakici, Cagri; Yigitbasi, Turkan; Sevencan, Nurhayat; Kayhan, BurcakBackground: Oxidative stress status in different cancer types was investigated before, but not studied in gastric intestinal metaplasia to the best of our knowledge. Purpose of this study is to examine whether there is a difference between oxidative stress status in patients with intestinal metaplasia (IM) compared to individuals without IM, we compared the serum levels of disulfide (SS), total thiol (TT) and native thiol (NT). Methods: This was a prospective, non-randomized case-control study including 67 patients with histopathologically confirmed IM and 60 individuals demographically matched in terms of age, gender, BMI, smoking status, and chronic diseases as control group. Results: The mean NT, TT and NT to TT (NT/TT) ratios were statistically significantly higher in IM group compared to controls ((351.71 +/- 81.9 mu mol/L vs. 271.82 +/- 54.13 mu mol/L, p=0.000), (391.5 +/- 92.69 mu mol/L vs. 308.59 +/- 55.53 mu mol/L, p=0.000) and (0.89 +/- 0.6 vs. 0.87 +/- 0.29, p=0.022), respectively). The mean SS to TT (SS/TT) ratio was significantly lower in IM group than control group (0.050 +/- 0.31 vs. 0.060 +/- 0.014, P=0.022). Median SS and mean SS/NT ratio was similar in both groups (16.3 (3.3-78) vs. 18.3 (10-32.7), p=0.271 and 0.055 +/- 0.041 vs. 0.070 +/- 0.019, p=0.068, respectively). In ROC analysis, cut off value of SS/NT for IM was found 0.062, in regression analysis, SS/NT <0.062 was found as an independently prognostic marker for IM (OR, 2.38; 95%CI: 1.168-4.865, P=0.017). Conclusions: SS/NT ratio lower than 0.062 was found as an independently prognostic marker for IM. This ratio could help to distinguish which patients should be followed closely for gastric cancer.Öğe Predictive value of FibroScan in detecting liver fibrosis in HBeAg negative patients with chronic hepatitis B whose HBV DNA 2000-20000 IU/ml with ALT 1-2 times the upper limit of normal and those with HBV DNA >20000 IU/ml and normal ALT(Kare Publ, 2021) Danis, Nilay; Akarca, Ulus Salih; Turan, Ilker; Karasu, Zeki; Ersoz, Galip; Yilmaz, Funda; Nart, DenizOBJECTIVE: In hepatitis B infection, it is difficult to make a treatment decision in patients with slightly elevated transaminases and HBV DNA level between 2000 and 20000 IU/ml, and in those with normal ALT, despite high levels of HBV DNA. Objectives: In HBeAg negative patients whose HBV DNA levels were between 2000 and 20000 IU/ml with ALT 1-2 times the upper limit of normal (ULN) and those with HBV DNA >20000 IU/ml and normal ALT, the concordance between liver fibrosis in biopsy and liver stiffness measured by transient elastography with FibroScan (R) (FS) was investigated, and diagnostic value of FS to predict the liver fibrosis was tested. METHODS: The patients were selected from the outpatient hepatology clinics between the dates of November 2014 and October 2016 among those who were taken liver biopsy. Transient elastography was obtained within 3 months after liver biopsy. The diagnostic value of FS in detecting advanced fibrosis or moderate to advanced (MTA) fibrosis was investigated for each group. RESULTS: In 38 patients with HBV DNA 2000-20000 IU/ml and ALT 1-2xULN, advanced fibrosis was detected in only one patient (2.6%) on liver biopsy, sensitivity of FS to show advanced fibrosis is 100%, specificity 78.3%, and diagnostic accuracy rate 79%. The area under curve was determined to be 0.892. In detecting MTA fibrosis, these values are 100%, 62%, 71%, and 0.810, respectively. Of 79 patients with HBV DNA >20000 IU/ml and normal ALT, five had advanced (5.5%) and 18 had MTA (23%) fibrosis. Sensitivity of FS in detecting advanced fibrosis was 100%, specificity 87.8%, and accuracy 88.6%, and these values for MTA fibrosis were 85.7%, 81%, and 82.3%, respectively. CONCLUSION: Because of false negativity in a few patients with HBV DNA >20000 IU/ml in detecting MTA, FS may be combined with other non-invasive techniques. Negative predictive values of FS in predicting advanced or MTA fibrosis were very high, while positive predictive values were low. However, FS may save several patients from liver biopsy.Öğe Ten-year single center experience in hepatotoxicity due to mushroom poisoning(Elsevier, 2022) Sarikaya, Ozan; Turan, Ilker; Gunsar, Fulya; Arslan, Aysenur; Danis, Nilay; Celik, Ferit; Ersoz, Galip[No abstract available]Öğe An unusual cause of anaemia: Rapunzel syndrome, a case report(Pakistan Medical Assoc, 2020) Ozkan, Aysegul Ertinmaz; Danis, Nilay; Altundal, Mustafa; Sevencan, Nurhayat Ozkan; Karatas, Fatih; Kayhan, BurcakTrichobezoars present with stomach ache and with a mass in the stomach. It's common in the young and middle-aged women having psychiatric disorder, presenting with stomach ache and existence of mass in the stomach. Although it's one of the rare causes of anaemia it should be considered when dealing with cases of chronic and unresponsive anaemia.
