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Öğe Fibulins: a new biomarker for pulmonary thromboembolism?(Taylor & Francis Ltd, 2020) Acat, Murat; Dikis, Ozlem Sengoren; Dulger, Seyhan Us; Akbay, Ertan; Karakaya, Ekrem; Haskul, Ismail; Chousein, Efsun GoncaObjectives Fibulin-1, -2, -4, and -5 have important role in several vascular diseases. We aimed to investigate if fibulin-4 and -5 can be used as a biomarker for pulmonary thromboembolism (PTE). Methods This is a prospective case control study. Thirthy patients diagnosed with PTE and 31 in the control group. Data on demographic characteristics, length of hospital stay, blood cell counts, troponin and BNP levels, arterial blood gases, radiological reports, indication for thromboembolitic treatment, intensive care unit (ICU) requirement, and loss of life were recorded for the patients group. Serum Fibulin-4 and Fibulin-5 levels were measured. Results Fibulin 4 levels correlated positively with female gender (p < .01, r = 0.433). Positive results were found in 14 (46.7%) patients for PESI.0.1; in 7 (23.3%) patients for D-dimer; in 7 (23.3%) patients for troponin-I; in 7(23.3%) patients for BNP. Median values for Fibulin 4 level were significantly higher in patients positive for BNP. Fibulin-5 level was found to be correlated with the presence of embolism (p = .041, r = 0.263). Conclusions Fibulin-4 and -5 have been shown to be relevant to cardiovascular biology and diseases. Experimental studies and observations in humans show that they may play a role in several cardiovascular diseases particularly pulmonary embolism.Öğe The relationship of thiol/disulfide homeostasis in the etiology of patients with obstructive sleep apnea: a case-control study(Taylor & Francis Ltd, 2020) Dikis, Ozlem Sengoren; Acat, Murat; Casim, Hasan; Haskul, Ismail; Neselioglu, Salim; Simsek, Abdullah; Erel, OzcanAim: Obstructive sleep apnea syndrome (OSAS) is a chronic and incapacitating disease that often requires lifelong care. This study aimed to evaluate the thiol/disulfide homeostasis in patients with OSAS, to compare the thiol/disulfide levels with the control group and to investigate their relationship with the severity of the disease. Material and methods: Patients who were admitted to the department of chest diseases, and diagnosed with OSAS using polysomnographic analysis (n = 186) and 144 patients who underwent polysomnography due to some reasons but ruled out of having OSAS were included in the study. Serum total thiol (TT), native thiol (SH), and disulfide thiol (SS) levels were measured from the participants; SS/SH, SS/TT, and SH/TT percent ratios were calculated and compared between the patient and control groups. Results: The mean (+/- SD) age of the patients and control participants was 52.0 +/- 11.5 years and 44.9 +/- 13.2 years, respectively. Compared to the control group, patients with OSAS had significantly lower SH (239.3 +/- 56.3 mu mol/L vs. 258.6 +/- 65.3 mu mol/L, t = 2.70, p =.007) and TT levels (273.2 +/- 60.1 mu mol/L vs. 292.9 +/- 67.5 mu mol/L, t = 2.64, p=.010). Age (OR = 1.04), serum albumin (OR = 12.67), ischemia-modified albumin (IMA) (OR = 0.12), SH (OR = 0.81), and TT (OR = 1.17) were independent predictors of OSAS. Conclusions: These results support the idea that decreased ST and TT levels are related to increased oxidative stress. On the other hand, impaired thiol balance may play a significant role in the pathogenesis of OSAS.