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Öğe Mean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux disease(E-Century Publishing Corporation, 2019) Sevencan, N.O.; Cesur, O.; Cakar, M.; Dogan, E.; Ozkan, A.E.; Benli, A.R.The aim of this study was to calculate the corrected rate of reflux in children with gastroesophageal reflux (GER)-like complaints by 24-hour pH monitoring and esophagogastroduodenoscopy (EGD), and to determine the utility of mean platelet volume (MPV) and red cell distribution width (RDW) as diagnostic biomarkers of GER disease (GERD) in children. The subjects in this prospective study were 109 children, 6 to 18 years old. Of them, 74 subjects were with GER symptoms and 35 healthy controls. The subjects were divided into three groups: those who underwent 24-hour pH monitoring (Group 1), those who underwent EGD together with pH monitoring (Group 2), and the healthy controls (Group 3). The results of pH monitoring and EGD and hematological parameters with controls were compared between Groups 1 and 2. In Groups 1 and 2, the overall rate of reflux was 40%, of esophagitis was 27.8%, and of Helicobacter pylori infection was 31.2%. The MPV and RDW cut-offs in subjects with reflux were ? 8.97 (sensi-tivity 89%, specificity 89%) and ? 12.78 (sensitivity 80%, specificity 97%), with an area under the Receiver Operating Characteristic (ROC) curve ± standard error (AUC ± SE) = 0.917 ± 0.027 (P < 0.001) and AUC ± SE = 0.866 ± 0.036 (P < 0.001), respectively. The endoscopic procedures are not practical due to being invasive and expensive. However, hemogram is a simple test which can be performed in an outpatient clinic. MPV and RDW calculated in hemogram could be easy, cost-effective, and high sensitive new biomarkers that can be used in children with GERD. © 2019, E-Century Publishing Corporation. All rights reserved.Öğe Reduced levels of circulating natural killer cells in children with celiac disease(Indonesian Pediatric Society Publishing House, 2020) Agin, M.; Sevinc, E.; Dogan, E.; Sevinc, N.Background Celiac disease (CD) is an autoimmune disease characterized by malabsorption. Serologic testing for CD consists of Ig A type of antitissue transglutaminase (tTG), antiendomysium (EMA). These tests are helpful in monitoring adherence to the gluten-free diet (GFD). Natural killer (NK) cell count alterations have been reported in various diseases, such as cancer, Crohn’s disease, malnutrition, and autoimmune disorders. Objective To compare peripheral blood NK cell counts in children with celiac disease (CD) to healthy controls. The second aim was to analyze for possible correlations between NK cells (CD3-/ CD16+, CD56+) and tissue transglutaminase (tTG)-IgA and tTG-IgG, as well as endomysial antibody EMA-IgA indicating . gluten sensitivity. Methods Fifty children with CD were compared to 48 healthy children as controls, with similar age and sex distribution. Peripheral blood NK cell counts were measured by flow cytometry. Results The median (P25-P75) ages of the 50 celiac patients (23 male; 46%) and 48 controls (21 male; 44%) were 10 (2-17) years and 9 (3-17) years, respectively. Mean follow-up duration was 3 years, ranging from 1-10 years. All CD patients had positive tTG-IgA and EMA-IgA tests. while it was negative in all (100 %) control patients. The absolute number of circulating CD16+ NK cells (259.52 vs. 1404.36 ?/L) and CD56+ NK cells (366.24 vs. 2440.46 ?/L) were significantly lower in the celiac group than the control group (P<0.05 for both). The absolute numbers of circulating white blood cells (7785 vs. 8165 ?/L) and lymphocytes (3106 vs. 3173 ?/L) were not significantly different between the celiac and control groups (P>0.05 for both). Correlation analysis between the absolute number of circulating NK cells and tTG-IgA, tTG-IgG, and EMA-IgA levels in CD patients revealed no significant relationships (P>0.05 for all). Conclusions Peripheral blood NK cell count are significantly lower in celiac patients than controls, hence, decreased NK cell counts may be an abnormal feature seen in autoimmune diseases. NK cell count in celiac patients has no significant correlations to tTG-IgA, tTG-IgG, or EMA-IgA levels. Therefore, NK cell count may be inappropriate marker for monitoring compliance to a gluten free diet. © 2020, Indonesian Pediatric Society Publishing House. All rights reserved.Öğe Vitamin D levels of children in Western Black Sea region of Turkey(Pamukkale University, 2021) Dogan, E.; Sevinç, N.Purpose: Vitamin D level varies personally according to the angle and duration of the sun's contact with the skin surface, the amount of nutrients taken, and the amount of oral intake. Besides nutritional habits, the location of settlements, their height from the sea and climate properties affect the serum 25(OH) D vitamin levels of individuals. In this study, it was aimed to determine the serum 25(OH) D vitamin levels of children in the Western Black Sea region. Materials and methods: Children who were living in the Western Black Sea region covering Karabük and neighbouring provinces, who applied to Karabük education and research hospital for any reason between January-December 2018, were measured for 25(OH) vitamin D. The children were divided into groups according to age, gender and seasonal application time, and their serum 25(OH) D vitamin levels were analyzed retrospectively. Results: A total of 709 children, 381 girls (53,7%) and 328 boys (46,3%), were included in the study. The mean serum 25(OH) vitamin D levels of the cases were 18,8 ng/mL, and it was found that there were differences according to age groups (1-4 years, 5-9 years, 10-14 years, 15-18 years) and seasons, but no difference was found according to the settlements. The mean serum 25(OH) vitamin D level in boys was 20.2 ng/mL and 17.3 ng/mL in girls and was found to be a significant difference between girls and boys (p<0,001). Complete deficiency, partial deficiency and normal serum 25(OH) vitamin D levels of cases were 12,8%, 68,7% and 18,5% (respectively). It was found that there was an inverse proportion between parathyroid hormone level and vitamin D level according to both seasonal and vitamin D levels. Conclusion: Vitamin D vitamin levels were low in the majority of children living in the Western Black Sea region. Although Vitamin D levels of children differed seasonally but there was no difference according to the settlement. © 2021, Pamukkale University. All rights reserved.Öğe The vitamin D status and serum eosinophilic cationic protein levels in infants with cow's milk protein allergy(E-Century Publishing Corporation, 2021) Dogan, E.; Sevinc, E.Eosinophil cationic protein (ECP) is a cytotoxic protein released from eosinophils. The level of ECP increases in some allergic diseases. Recently, vitamin D deficiency has been suggested to be a risk factor for childhood allergic disease. The first aim of the study is to measure the serum vitamin D levels and ECP in infants with cow's milk protein allergy (CMPA) and compare them with controls. The second aim of this study is to investigate whether vitamin D levels are correlated with ECP or not. Sixty-two infants with CMPA were compared to 58 healthy, similar to distribution of age and sex normal infants as controls. The serum ECP levels were detected by an immunoassay system. Serum 25(OH)D levels were measured by using an enzyme-linked immunoassay kit. Vitamin D deficiency was defined as a serum 25(OH)D level of < 10 ng/mL and sufficient 30 ng/mL. The median serum ECP level in the CMPA group was significantly higher than in the control group (51.45 and 17.55 ng/mL, respectively, P = 0.001). There were no significant differences between groups with regards to median 25(OH)D levels (29.31 ± 1.67 and 27.32 ± 1.41 ng/mL, respectively, P = 0.646). The serum 25(OH)D levels were under 30 ng/mL in 38 of infants with CMPA (61.2%) and in 32 of controls (55.1%). Correlation analysis between the serum 25(OH)D level and ECP of infants with CMPA have revealed no significant relation (P = 0.888). Our results do not support the hypothesis that vitamin D deficiency may be a risk factor for CMPA. © 2020 E-Century Publishing Corporation. All rights reserved.
