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Öğe The anxiety of children and their mothers waiting for examination in the paediatric outpatient clinic: a cross-sectional descriptive correlational study(Routledge Journals, Taylor & Francis Ltd, 2024) Arslan, Seymanur Ozdemir; Sahin, Ozlem Oztuerk; Dogan, ErkanThe study was conducted with 330 children and their mothers waiting in line for examination in pediatric outpatient clinics. Child and Mother Information Forms, State-Trait Anxiety Inventory for Children, and State-Trait Anxiety Inventory were used as data collection tools. The study revealed that both children and their mothers experience moderate anxiety during the waiting period in the outpatient clinic and that there is a positive relationship between state and trait anxiety levels of children and mothers. The study observed that the state anxiety levels of children and their mothers were higher in children with previous hospitalization experience. Both state and trait anxiety levels were lower in children informed about visiting the hospital. It was concluded that prolonging the outpatient clinic waiting period increases anxiety levels in children and their mothers.Öğe Assessment of balance skills and falling risk in children with congenital bilateral profound sensorineural hearing loss(Elsevier Ireland Ltd, 2019) Soylemez, Emre; Ertugrul, Suha; Dogan, ErkanObjective: To evaluate the balance skills and falling risk in children with a congenital bilateral profound sensorineural hearing loss (CBPSNHL). Methods: 25 children with CBPSNHL and healthy 25 children with similar age and gender were included in the study. The flamingo balance test, the tandem stance test, and the one-leg standing test were performed to assess the patients' static balance skills. The pediatric balance scale (PBS) was used to evaluate the dynamic balance. Visual analog scale (VAS) was applied to the patients assess the frequency of falls. Results: The flamingo balance test, the tandem stance test, and the one-leg standing test in the children with CBPSNHL were all significantly worse than the control group. Although the scores of PBS in patients with CBPSNHL were significantly lower than the control group (p < 0.001), the results of both groups were consistent with a low risk of falls. There was no significant difference between the VAS scores indicating the frequency of falls among the groups (p = 0.552). Conclusion: Static and dynamic balance skills of the children with CBPSNHL are significantly impaired compared to their healthy peers. Children with CBPSNHL also have a lower risk of falling just like their healthy peers and there is no significant difference between their falling frequencies. Balance skills of children with CBPSNHL can be assessed quickly and effectively on a hard floor (eyes closed), with a tandem standing test or a one-leg standing test.Öğe Baby-led complementary feeding: Randomized controlled study(Wiley, 2018) Dogan, Erkan; Yilmaz, Gonca; Caylan, Nilgun; Turgut, Mahmut; Gokcay, Gulbin; Oguz, Melahat MelekBackground Baby-led weaning (BLW) is an approach to introducing solid foods to infants that gives control of the feeding process to the infant. Anecdotal evidence suggests that BLW is becoming popular with parents, but scientific research is limited to a few publications. This study assessed growth, hematological parameters and iron intake in 6-12-month-old infants fed by traditional or baby-led complementary feeding. Methods We recruited 280 healthy 5-6-month-old infants allocated to a control (traditional spoon feeding; TSF) group or an intervention (BLW) group in a randomized controlled trial. Infant growth, hematologic parameters and iron intake were evaluated at age 12 months. Results Infants in the TSF were significantly heavier than those in the BLW group. Mean weight in the BLW group was 10.4 +/- 0.9 kg compared with 11.1 +/- 0.5 kg in the TSF group. There was no statistically significant difference in the iron intake from complementary foods between the BLW (7.97 +/- 1.37 mg/day) and TSF (7.90 +/- 1.68 mg/day) participants who completed the diet records. Hematologic parameters were similar at 12 months. The incidence of choking reported in the weekly interviews was not different between the groups. Conclusions To the best of our knowledge, this is the first randomized -controlled study to have examined the impact of weaning method on iron intake, hematological parameters and growth in breast-fed infants. BLW can be an alternative complementary feeding type without increasing the risk of iron deficiency, choking or growth impairment.Öğe Blood and faecal lead levels in children with various functional gastrointestinal disorders(Ediciones Doyma S A, 2020) Sevinc, Nergiz; Bilici, Namik; Sevinc, Eylem; Dogan, ErkanIntroduction: To investigate the blood lead levels (BLLs) and faecal lead levels (FLLs) in children with various functional gastrointestinal disorders (FGIDs) and compare them with controls. Patients and methods: One hundred and 2 children with FGIDs defined by the Rome IV criteria, aged 4-18 years, and one hundred and 2 sex matched healthy children were enrolled in the study. Children with FGIDs were divided into 3 subgroups as functional constipation (FC) (n = 36), functional abdominal pain (FAP) (n = 36) and functional nausea (FN) (n = 30). The lead levels were measured using atomic absorption spectrometer. Results: The median BLLs in the FGIDs group was significantly higher than in controls (5.12 and 1.77 mu g/dL, respectively). The BLLs were above 5 mu g/dL in 51,9% of children with FGIDs. There was statistically significant difference in BLLs between FC subgroup and the other subgroups (FAP and FN) (P=.003, P<.001 respectively). The FLLs in the FGIDs group was significantly higher than in controls (28.08 and 0.01 mu g/g, respectively). There was no significant difference in FLLs between FC subgroup and the other subgroups (P=.992, P=.989 respectively). No significant relation found between BLLs and FLLs of the FGIDs group (P =.123). Conclusion: This study revealed that children with FGIDs had higher BLLs and FLLs than controls and also more than half of children with FGIDs had BLLs >= 5 mu g/dL which is toxic level. These results might revive the question of whether or not clinician need to evaluate routine BLLs in children with FGIDs. (C) 2020 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.Öğe Blood and Stool Arsenic Levels Are Decisive for Diagnosing Children's Functional Gastrointestinal Disease (FGD)(Springernature, 2022) Bilici, Namik; Dogan, Erkan; Sevinc, Eylem; Sevinc, Nergiz; Akinci, Gulsema; Musmul, Ahmet; Cengiz, MustafaPediatric gastroenteritis is a potentially fatal disease that accounts for 10% of childhood deaths. The main risk is environmental factors and nutrition. Arsenic (As) is commonly found in the earth's crust. As is an essential element that can form many organic compounds. In children, it causes diarrhea, gums, tongue lesions, diabetes, conjunctivitis, ocular opacity, and impaired immune response. It also causes low growth, mental retardation, and neurological problems. It is also known as the cause of many cancers that originate at an early age. Regionally, there is an iron and steel industry for almost a century. According to the Rome IV criteria, the blood and stools of 50 children aged 6-18 years, male and female, living in our province with functional gastrointestinal disease (FGD), were screened for As, and compared with the Healthy group (control) of 30 children. The results were evaluated with the Mann-Whitney Rank Sum Test. When blood and stool As values in males were compared with control samples, a high level of significance (p = 0.001) was found between both blood and stool As values in sick males and the control group (p < 0.005). In females, blood and stool As median values were also highly significant when compared with the control group (p = 0.001). According to these data, when the sick children (children with male and female gender) are compared with the healthy ones, the difference is highly significant (p < 0.005). High blood As levels in children indicate environmental pollution. It can be said that blood As levels are high as a result of food, water, and inhaler exposure. The presence of a high level of significant difference in stool means that the amount of As is high in the foods consumed daily. High levels of As are in blood and stools; It was evaluated that FGD could be the cause of nausea, diarrhea, vomiting, and colic. The increase in blood and stool As values due to environmental pollution is an important reason for FGD. For diseases of uncertain cause (such as FGD) resulting from chronic As exposure, blood and especially stool As values are more significant than urinary As levels. In conclusion, As a diagnostic criterion, it was concluded that blood and stool As values are an important marker in children with functional abdominal pain with other metals.Öğe Clinical and Laboratory Effects of Foodborne Illness in Children(Mary Ann Liebert, Inc, 2024) Deniz, Yusuf; Ekmen, Sadrettin; Dogan, Erkan; Calis, Seyda OzdenThe World Health Organization estimates that 31 foodborne pathogen account for 600 million cases of illness annually. This study, conducted in a pediatric emergency department in Turkey, addresses the limited research on pediatric foodborne diseases (FD) in the country, exposing a significant knowledge gap. Analyzing 17,091 pediatric cases, 106 FD cases were identified, predominantly affecting boys (94.3%) with an average age of 7.65 +/- 6.51 years. Remarkably, no patients required pediatric intensive care admission, and no mortalities were recorded. Hyponatremia emerged as a prevalent electrolyte disorder in pediatric FD, while hyperkalemia was notably observed in children under 5. The study emphasizes the severity of FD in children under 5, reflected in longer hospital stays, underscoring the urgent need for targeted interventions and improved detection methods in pediatric FD.Öğe Does Prebiotic Food Consumption Reduce Sleep Disorder Symptoms in Children With and Without Asthma? A Case-control Study(Galenos Publ House, 2024) Sahin, Ozlem Ozturk; Dogan, Erkan; Topan, Aysel; Demirer, Busra; Tasdelen, YelizObjective: This study aims to evaluate the impact of prebiotic food consumption on sleep disturbance symptoms in children with and without asthma. Method: This is a case -control study. Data were collected from 55 children with asthma and 70 children without asthma, aged 6 to 12 years. Data collection included the Sleep Disturbance Scale for Children (SDSC), Prebiotic Food Consumption Frequency Form, and Childhood Asthma Control Test. The asthma control level of children was determined by a pediatrician following the Global Initiative for Asthma's guidelines. Results: The average age of children with asthma was 9.16 +/- 3.11, while for children without asthma, it was 9.39 +/- 3.24. No significant differences were found between children with and without asthma in daytime napping, nighttime awakening, SDSC score, and daily prebiotic food consumption (p>0.05). It was observed that children with asthma used more prebiotic-enriched products than children without asthma (p<0.012). There was no significant difference in asthma control level, SDSC score, and prebiotic food consumption between children with and without asthma (p>0.05). Furthermore, no significant relationship was found between the SDSC score and prebiotic food consumption in children with and without asthma (p>0.05). Conclusion: Prebiotic food consumption's role in determining sleep disturbances and asthma control levels in children with asthma remains uncertain. Further research is needed on the use of prebiotics in children with asthma.Öğe Evaluation of Gentamicin Ototoxicity in Newborn Infants: A Retrospective Observational Study(Mashhad Univ Med Sciences, 2021) Ekmen, Sadrettin; Dogan, ErkanBackground The main purpose of this study was to demonstrate the effect of gentamicin on hearing tests in newborns treated with gentamicin in our NICU, and to contribute to the selection of antibiotics more consciously. Materials and Methods: Infants who Nvere hospitalized and followed up in the NICU of Karabuk University Medical Faculty Hospital, Karabuk, Turkey, between December 2019 and November 2020 were included in our study. During the study period, 331 infants hospitalized in the NICU and meeting the inclusion criteria were included.The infants were divided into two groups, with and without gentamicin treatment, and their demographic characteristics, respiratory support treatment and hearing test results were retrospectively analyzed and the results were compared. Automated auditory brainstem response (ABR) was used for newborn hearing screening at discharge. Results: Demographically, maternal age and birth weight were found to be significantly lower in gentamicin patients. Delivery method and gestational age were similar between the two groups. While the rates of passing the first test in the ABR screening were higher in the gentamicin group (p=0.051), only 1 infant in the same group failed the ABR second screening. This infant was 34 weeks old, a fraternal twin born at 2200 g, and no hearing loss was found in the infant's twin. When the anamnesis was observed in detail, the infants' uncle manifested a history of hospitalization for the treatment of urinary tract infection in his youth. In the meantime, his history of amikacin treatment and consequent experience of sensorineural hearing loss was revealed. Conclusion We concluded that gentamicin does not affect the hearing test when it is not used in the short-term (5-7 days), extended dosing intervals (24-48 hours), and ototoxic drugs such as loop diuretics.Öğe Evaluation of interleukin 8 polymorphisms (-251T/A and +781C/T) in patients with hepatocellular carcinoma: a meta-analysis(Termedia Publishing House Ltd, 2021) Aleagha, Omid Emami; Moeinzadeh, Forouzan; Shokouh, Seyedeh Farnaz Moeini; Dogan, Erkan; Sadeghi, MasoudAim of the study: We reported the association between interleukin 8 (IL-8) polymorphisms (-251T/A and +781C/T) and hepatocellular carcinoma (HCC) risk in a meta-analysis. Material and methods: Scopus, PubMed, Web of Science, and Cochrane Library databases were searched until 21 November 2021. The analyses were performed by RevMan 5.3 software using odds ratios (ORs) and 95% confidence intervals (Cis). Also, the analysis of publication bias was performed by CMA 2.0 software. Results: Searching databases/sources, five articles including ten studies were entered into the meta-analysis. The pooled ORs for -251T/A polymorphism were 1.07 (p = 0.55), 1.04 (p = 0.75), 1.31 (p = 0.24), 1.24 (p = 0.31), and 1.85 (p = 0.29) for allele, homozygote, heterozygote, recessive and dominant models, respectively. With regards to +781C/Tpolymorphism, the pooled ORs were 0.74 (p = 0.07), 0.53 (p = 0.03), 0.83 (p = 0.41), 0.75 (p = 0.19), and 0.57 (p = 0.02) for allele, homozygote, heterozygote, recessive, and dominant models, respectively. Conclusions: The findings of the meta-analysis showed a lack of significant association between IL-8 (-251T/A) polymorphism and the HCC risk, whereas the TT genotype of IL-8 (+781C/T) polymorphism had a protective role in HCC.Öğe The Frequency of Atopic Dermatitis and Other Skin Manifestations in Infants with Cow's Milk Protein Allergy in Karabuk, Turkey(Mashhad Univ Med Sciences, 2021) Dogan, Erkan; Sevinc, Eylem; Gamsizkan, Zerrin; Korkut, Burcu; Sevinc, NergizBackground Atopic dermatitis (AD) is the most common skin disease in childhood, and Cow's milk protein allergy (CMPA) is the most common cause of food allergies in infancy and may be characterized by atopic dermatitis with skin involvement as the first finding. The aim of this study is to determine the serum eosinophil cationic protein (sECP) levels, eosinophil counts and the frequency of AD and other skin manifestation among infants with CMPA. Materials and Methods: This cross-sectional study was conducted in Karabuk province, Turkey. Eighty-three infants who were diagnosed with CMPA and followed at the Karabuk Training Hospital Pediatric outpatient clinic. The first group consisted of 52 infants presenting with skin manifestations. The second group consisted of 31 infants who were not presenting skin manifestations. The sECP level of infants in both groups was measured using an Immulite 2000 XPi analyzer Immunoassay System (Germany). Results: Of 83 infants with CMPA, 62.6% (n=52) were detected skin involvement as the first finding. The proportions of atopic dermatitis and urticaria in CMPA infants with skin involvement were 90.4% and 9.6% respectively. The median sECP level and eosinophil counts (56.5 ng/mL vs 470/mm(3), p-value=0.001), in skin manifestations with CMPA group were significantly higher than that in the CMPA group without skin manifestations (33.1 ng/mL vs. 270/mm(3), p-value=0.006). Conclusion This study revealed that AD is the most common skin manifestation of CMPA and also found higher sECP levels in infants with skin involvement. The frequency of both diseases, which are easily treated with elimination diet, is increasing day by day.Öğe Mean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux disease(E-Century Publishing Corp, 2019) Sevencan, Nurhayat Ozkan; Cesur, Ozkan; Cakar, Murat; Dogan, Erkan; Ozkan, Aysegul Ertinmaz; Benli, Ali RamazanThe aim of this study was to calculate the corrected rate of reflux in children with gastroesophageal reflux (GER)-like complaints by 24-hour pH monitoring and esophagogastroduodenoscopy (EGD), and to determine the utility of mean platelet volume (MPV) and red cell distribution width (RDW) as diagnostic biomarkers of GER disease (GERD) in children. The subjects in this prospective study were 109 children, 6 to 18 years old. Of them, 74 subjects were with GER symptoms and 35 healthy controls. The subjects were divided into three groups: those who underwent 24-hour pH monitoring (Group 1), those who underwent EGD together with pH monitoring (Group 2), and the healthy controls (Group 3). The results of pH monitoring and EGD and hematological parameters with controls were compared between Groups 1 and 2. In Groups 1 and 2, the overall rate of reflux was 40%, of esophagitis was 27.8%, and of Helicobacter pylori infection was 31.2%. The MPV and RDW cut-offs in subjects with reflux were <= 8.97 (sensitivity 89%, specificity 89%) and <= 12.78 (sensitivity 80%, specificity 97%), with an area under the Receiver Operating Characteristic (ROC) curve +/- standard error (AUC +/- SE) = 0.917 +/- 0.027 (P < 0.001) and AUC +/- SE = 0.866 +/- 0.036 (P < 0.001), respectively. The endoscopic procedures are not practical due to being invasive and expensive. However, hemogram is a simple test which can be performed in an outpatient clinic. MPV and RDW calculated in hemogram could be easy, cost-effective, and high sensitive new biomarkers that can be used in children with GERD.Öğe Pre-Endoscopic viral screening of children during the Covid-19 pandemic(Bayrakol Medical Publisher, 2022) Dogan, Erkan; Sevinc, Eylem; Sevinc, Nergiz; Basar, ErhanAim: Transmission of SARS-CoV-2 infection can easily occur through direct or close contact with infected people, just as with other infectious diseases. Therefore, it is important to detect it prior to the intervention for protecting the health of both the healthcare worker and the patient. In the study, it was aimed to determine the seroposidvity rates of acute respiratory syndrome coronavirus 2, hepatitis A, hepatitis 8, hepatitis C virus and human immune deficiency virus infections among children who underwent gastrointestinal endoscopy. Material and Methods: The study was conducted at the Department of Pediatric Gastroenterology of the Karabuk University in Turkey from December 2020 to December of 2021. A total of 175 children were included in the study. The study was divided into three age groups as follows: 1-6 years old, 7-12 years old and 13-18 years old. All children were screened for acute respiratory syndrome coronavirus 2. hepatitis A, hepatitis B, hepatitis C virus and human immune deficiency virus infections. Results: The median age was 12.5 years (1-18). The seroprevalence of acute respiratory syndrome coronavirus 2, Anti-HAV IgM, Anti-HAV IgG, HBsAg, AntiHBs, Anti-HCV, Anti-HIV and were detected 0.57%, 0.57%, 42.8%, 0%, 58.8%. 1.1% and 0 % respectively. The seroprevalence of Anti-HAV IgG was significantly higher in children aged 1-6 years than in the group aged 13-18 years (95.7 vs 25.2: x2=48.1, p=0.001). Discussion: Although seroprevalence rates prior to endoscopy were low in this study, viral screening, except for hepatitis A infection, is essential for the safety of both patients and healthcare.Öğe Prediction of the Course of Transient Tachypnea of the Newborn by Blood Laboratory Parameters at the Time of Admission(Kowsar Corp, 2021) Ekmen, Sadrettin; Dogan, ErkanBackground: Transient tachypnea of the newborn (TTN) is a common but mild respiratory problem seen in late preterm and term newborns. However, it may sometimes cause severe morbidity. Objectives: Therefore, biomarkers that can predict TTN severity may aid the clinician in determining the need for intensive care. Our aim was to identify whether blood gases and complete blood count parameters could be utilized to predict the severity of TTN.s Methods: We retrospectively examined the medical records of newborns (> 37 weeks gestation, > 2000 grams) diagnosed with TTN who were hospitalized in the Neonatal Intensive Care Unit (NICU) of Karabuk University Faculty of Medicine, Training and Research Hospital, Karabuk/Turkey between June 2019 and June 2020. Patients were grouped according to the length of stay in the NICU. Group 1 included patients that did not require NICU monitoring after 48 hours, and group 2 included patients who continued to require NICU monitoring after 48 hours. Blood gases and complete blood count parameters were compared between the two groups. Results: During the study period, 91 newborns were hospitalized in the NICU due to respiratory distress. Thirty-nine patients who did not meet the inclusion criteria were excluded. Gestational age and birth weight were significantly lower in group 2 (P < 0.05). There were no significant differences between the groups in terms of leukocyte count, hemoglobin level, mean platelet volume (MPV), and platelet count. Partial carbon dioxide pressure (PCO2) was significantly elevated, and base excess (BE) was significantly greater in group 2. Conclusions: We determined a relationship between a prolonged stay in NICU and the levels of PCO2 and BE among patients hospitalized with a diagnosis of TTN. Therefore, PCO2 and BE values may be valuable to determine the prognosis of TTN in the early period. Despite being one of the most common causes of intensive care admission in the newborn population, there is limited data on the diagnosis, treatment, and prognosis of TTN; thus, we believe that our results will shed light on this problem.Öğe Reduced levels of circulating natural killer cells in children with celiac disease(Indonesian Pediatric Soc Publishing House, 2020) Agin, Mehmet; Sevinc, Eylem; Dogan, Erkan; Sevinc, NergizBackground Celiac disease (CD) is an autoimmune disease characterized by malabsorption. Serologic testing for CD consists of Ig A type of antitissue transglutaminase (tTG), antiendomysium (EMA). These tests are helpful in monitoring adherence to the gluten-free diet (GFD). Natural killer (NK) cell count alterations have been reported in various diseases, such as cancer, Crohn's disease, malnutrition, and autoimmune disorders. Objective To compare peripheral blood NK cell counts in children with celiac disease (CD) to healthy controls. The second aim was to analyze for possible correlations between NK cells (CD3-/CD16+, CD56+) and tissue transglutaminase (tTG)- IgA and tTG-IgG, as well as endomysial antibody EMA-IgA indicating. gluten sensitivity. Methods Fifty children with CD were compared to 48 healthy children as controls, with similar age and sex distribution. Peripheral blood NK cell counts were measured by flow cytometry. Results The median (P25-P75) ages of the 50 celiac patients (23 male; 46%) and 48 controls (21 male; 44%) were 10 (2-17) years and 9 (3-17) years, respectively. Mean follow-up duration was 3 years, ranging from 1-10 years. All CD patients had positive tTG-IgA and EMA-IgA tests. while it was negative in all (100 %) control patients. The absolute number of circulating CD16+ NK cells (259.52 vs. 1404.36 mu/L) and CD56 + NK cells (366.24 vs. 2440.46 mu/L) were significantly lower in the celiac group than the control group (P<0.05 for both). The absolute numbers of circulating white blood cells (7785 vs. 8165 mu/L) and lymphocytes (3106 vs. 3173 mu/L) were not significantly different between the celiac and control groups (P>0.05 for both). Correlation analysis between the absolute number of circulating NK cells and tTG-IgA, tTG-IgG, and EMA-IgA levels in CD patients revealed no significant relationships (P>0.05 for all). Conclusions Peripheral blood NK cell count are significantly lower in celiac patients than controls, hence, decreased NK cell counts may be an abnormal feature seen in autoimmune diseases. NK cell count in celiac patients has no significant correlations to tTG-IgA, tTG-IgG, or EMA-IgA levels. Therefore, NK cell count may be inappropriate marker for monitoring compliance to a gluten free diet.Öğe Rotavirus Infections: A 2-Year Comprehensive Review in Admitted Pediastric Patients Amid Conflicting National Policies(Mary Ann Liebert, Inc, 2024) Deniz, Yusuf; Demircioglu, Burak; Kuter-Emeklioglu, Irem; Ekmen, Sadrettin; Sevinc, Eylem; Dogan, ErkanHighlighting rotavirus (RV) as a significant food and waterborne pathogen, particularly affecting infants and children, causing serious gastrointestinal infections and dehydration, is important. It should be noted that there are significant debates regarding the effectiveness and outcomes of RV vaccination. In contrast to Turkey's nonmandatory vaccination policy, many developed countries implement mandatory vaccination policies, raising questions about their impact on disease prevalence and healthcare expenditures. Our study aims to comprehensively understand RV infections in Turkey and compare them with countries that have mandatory vaccination policies. We found similar, and even better, hospitalization rates, length of hospital stays, and laboratory parameters demonstrating the effectiveness of Turkey's independent vaccination approach. These findings contribute valuable insights to global vaccination strategies and disease control.Öğe Serum eosinophilic cationic protein level and hematological parameters in infants with cow's milk protein allergy(Indonesian Pediatric Soc Publishing House, 2019) Dogan, Erkan; Sevinc, EylemBackground Various biomarkers have been investigated in the diagnosis of cow's milk protein allergy (CMPA) in infants. To our knowledge, no prior studies have evaluated serum eosinophil cationic protein (sECP), neutrophil-lymphocyte ratio (NLR), and mean platelet volume (MPV) concurrently in infants with CMPA. Objective To compare sECP levels, MPV, and NLR in infants with and without CMPA, as well as to investigate the suitability of these parameters as biomarkers in the diagnosis of CMPA. Methods Fifty-six children with CMPA were compared to 40 healthy, similar to distribution of age and sex normal infants as controls. The serum ECP levels were detected by a chemiluminescence assay. The MPV values were calculated by devices in hemogram parameters. The NLR values were obtained by dividing the neutrophil count by the lymphocyte count. Results The median sECP level in the CMPA group was significantly higher than in the control group (23.5 and 9.27 ng/ mL, respectively; P=0.001). However, there were no significant differences between groups with regards to median MPV (8.5 and 8.6 fL, respectively; P=0.149) and median NLR (0.35 and 0.37 respectively; P =0.637). Correlation analysis of sECP level with MPV and NLR in the CMPA group revealed no significant relationships (P >0.05 for both). In the Receiver-operating characteristic (ROC) curve analysis, the optimal cut-off levels to identify CMPA for sECP, MPV, and NLR were 18.4 ng/mL (60.7% sensitivity, 97.5% specificity, and AUC: 0.831), 10.05 fL (54% sensitivity, 77.5% specificity, and AUC: 0.413) and 0.97 (14.3% sensitivity, 50% specificity, and AUC: 0.528), respectively. Conclusions The sECP level and blood eosinophil count are significantly higher in infants with CMPA, but MPV and NLR do not differ between infants with and without CMPA. There are also no significant correlations in the CMPA group between sECP and MPV, as well as sECP and NLR. Serum ECP might be useful as a potential biomarker for diagnosing CMPA.Öğe SLC26A3 mutation in Turkish neonate and her sibling with congenital chloride diarrhea(Turkish Pediatrics Assoc, 2020) Dogan, Erkan; Sevinc, Eylem; Goktas, Mehmet Akif; Ekmen, Sadrettin; Yildiz, NihalCongenital chloride diarrhea is a rare cause of severe infantile diarrhea with excessive chloride excretion. Mutations in the SLC26A3 gene cause congenital chloride diarrhea. It generally becomes apparent in the neonatal period and is characterized by electrolyte imbalances, metabolic alkalosis, and failure to thrive. The diagnosis of congenital chloride diarrhea is based on detecting excessive chloride in the stool (90 mmol/L). We report a Turkish neonate with congenital chloride diarrhea whose sibling had the same disease. The newborn was born by cesarean delivery. Diarrhea, vomiting, and weight loss started soon after birth. She was diagnosed as having congenital chloride diarrhea based on its typical clinical signs and a high concentration of stool chloride and was confirmed by genetic analysis. She was treated by means of salt supplementations and lansoprazole. Family history may play an important role in the early diagnosis because the disease is inherited autosomal recessively.Öğe The vitamin D status and serum eosinophilic cationic protein levels in infants with cow's milk protein allergy(E-Century Publishing Corp, 2020) Dogan, Erkan; Sevinc, EylemEosinophil cationic protein (ECP) is a cytotoxic protein released from eosinophils. The level of ECP increases in some allergic diseases. Recently, vitamin D deficiency has been suggested to be a risk factor for childhood allergic disease. The first aim of the study is to measure the serum vitamin D levels and ECP in infants with cow's milk protein allergy (CMPA) and compare them with controls. The second aim of this study is to investigate whether vitamin D levels are correlated with ECP or not. Sixty-two infants with CMPA were compared to 58 healthy, similar to distribution of age and sex normal infants as controls. The serum ECP levels were detected by an immunoassay system. Serum 25(OH)D levels were measured by using an enzyme-linked immunoassay kit. Vitamin D deficiency was defined as a serum 25(OH)D level of < 10 ng/mL and sufficient 30 ng/mL. The median serum ECP level in the CMPA group was significantly higher than in the control group (51.45 and 17.55 ng/mL, respectively, P = 0.001). There were no significant differences between groups with regards to median 25(OH)D levels (29.31 +/- 1.67 and 27.32 +/- 1.41 ng/mL, respectively, P = 0.646). The serum 25(OH)D levels were under 30 ng/mL in 38 of infants with CMPA (61.2%) and in 32 of controls (55.1%). Correlation analysis between the serum 25(OH)D level and ECP of infants with CMPA have revealed no significant relation (P = 0.888). Our results do not support the hypothesis that vitamin D deficiency may be a risk factor for CMPA.
