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    Effect of Coenzyme Q10 on Acute Pulmonary Damage Following the Experimental Thoracic Trauma
    (Derman Medical Publ, 2015) Koyuncu, Murat; Avsarogullari, Omer Levent; Duman, Ali; Deniz, Kemal; Saraymen, Recep; Ozkan, Seda; Durukan, Polat
    Aim: Pulmonary contusion negatively affects prognosis in the case of damages following a trauma. Objective of this experimental study performed in Turkey was to evaluate effects of coenzyme Q10 on primary and secondary damages of pulmonary contusion following experimental thoracic blunt trauma using biochemical and histopathological parameters. Material and Method: A total of 56 Wistar Albino female rats with a mean weight of 205 45 g were included in this study. Rats were randomly divided into seven groups with each group having eight rats. A trauma device which consisted of a fixed platform, and an aluminium tube was prepared. Rats were administered 2.45 J of chest impact energy in order to generate pulmonary contusion. Control and Study groups were named according to the sacrificed time. No process (trauma and/or medication) was performed in the sham group, while only trauma was induced in the controls. On the other hand, after induced trauma. intraperitoneal Q10 (0.-24.-48. hours) was administered to study group. Rats were sacrificed at the end of the after trauma 24, 48 and 72 hours. and their blood and lung tissue samples were analyzed. Results: No significant difference was found between sham and Study-72 groups in terms of high-sensitivity C-reactive protein. On the histopathological examination, no significant difference was found between study and control groups. While no significant difference was found between the sham and study groups, significant difference was observed between sham and control groups. Discussion: Coenzyme Q10, an antioxidant agent, can be used as an antioxidant agent in order to reduce the secondary damage in blunt thoracic trauma.
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    When should cardiopulmonary resuscitation be stopped: opinions of the emergency medicine physicians in turkey
    (2015) Koyuncu, Murat; Duman, Ali; Öztürk, Derya; İpekçi, Afsin; Altınbilek, Ertuğrul; Topal, Fatih Esad; Türkdoğan, Kenan Ahmet
    We aimed to define point of view of the Emergency Medicine Physicians (EMPs) working in emergency services in Turkey about the duration of cardiopulmonary resuscitation (CPR) and to determine whether a standardization could be developed for CPR duration in the light of this information. After approval of the ethics committee, a survey form was prepared using Google Document and internet access address was sent to 1.404 EMPs via mail. A total of 428 persons responded the survey and 426 appropriate responses were assessed. Of the EMPs, 64.2% suggested that the persons who perform and/or manage CPR must make the decision for the duration. The participants stated that CPR time should be longer at younger ages and shorten with aging and that duration of CPR must be shorter in patients with the end-stage. The decision for 'Do Not Attempt Resuscitation (DNAR)' can not be made in our country. Legal studies must be conducted for law, regulations and notification in order to made decision for DNAR only in terminal stage patients. Therefore there must not be a law, regulation or CPR guide including exact duration for CPR