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    Synthesis, characterization and investigation of anticancer activities of schiff bases and some transition metal complexes containing 2,5,6-trisubstituted imidazothiadiazole derivatives
    (Karabük Üniversitesi, Lisansüstü Eğitim Enstitüsü, 2024) Elmahdi, Ahmed Hamdi Mirghani; Uysal, Şaban
    In this study, 16 novel 2,5,6-trisubstituted imidazothiadiazole-derivatived ligands and their Ag (I) complexes were synthesized and characterized using various spectroscopic analysis techniques. First, imidazo[2,1-b][1,3,4]thiadiazole derivatives 3[a-d] were obtained from the reaction of 5-amino-1,3,4-thiadiazole-2-thiol with four different benzyl bromide derivatives in the presence of KOH in an ethanol medium. In the next step, the products reacted with substituted phenacyl bromide derivatives 4[a-d] under refluxed ethanol for 24 hours to obtain substituted 2-(benzylthio)-6-phenylimidazo[2,1-b][1,3,4]thiadiazole derivatives (5-20). Compo-unds (21-36) were obtained by attaching a carbonyl group to carbon number 5 of the imidazothiadiazole group in these compounds with the help of Vilsmeier-Haack reagent. The resultant compounds were reacted in an ethanolic medium to synthesize the novel (AH1-AH16) ligands by adding ethylenediamine to compounds (21-36) in a 1:2 molar ratio. The Ag(I) complexes of the resultant ligands were synthesized by mixing silver acetate with the (AH1-AH16) ligands in a dimethyl sulfoxide medium to obtain [Ag(AH1-AH16)]CH3COO coordination compounds. All the synthesized compounds were analyzed using FTIR, 1H NMR, 13C NMR, mass spectroscopy, elemental analysis, ICP-OES, and thermogravimetric analysis techniques. Molecular docking studies were performed using the MOE program to check the binding affinity between the synthesized ligands and the 3p0v protein. The study investigates the cytotoxic effect of the ligands and complexes on A549 cells (non-small cell lung cancer cells) using the MTT assay, revealing that the AH1, AH3, AH4, AH5, and AH13 ligands and their complexes have an anticancer potential.