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Change of complete blood count parameters according to blood type and smoking
(Ondokuz Mayis Universitesi, 2023) Inci, H.
In this study, it was aimed to investigate the change in the parameters of complete blood count depending on blood type and smoking status. The individuals were grouped according to their blood group type and status of cigarette use, and the statistical differences in their levels of Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR), and Mean Platelet Volume/Lymphocyte ratio (MPVLR) were evaluated.3119 individuals participated in the study. 26.67% of them were smokers. According to the ABO blood group system, 44.47% of the participants had type A, 32.48% had type O, 16.09% had type B, and 6.96% had type AB. 88.81% of the participants were Rh(+) and 11.19% of them were Rh(-). The NLR, PLR, and MPVLR of the smokers were higher than those of the non-smokers. The participants’ NLR, PLR, and MPVLR levels showed statistically significant differences depending on ABO and Rh blood groups. This difference was seen to arise from ARh (+) individuals. The NLR, PLR, and MPVLR levels were the highest in ARh (+) individuals and the lowest in the ABRh (-) individuals. The NLR, PLR, and MPVLR values were the highest in the ARh (+) smokers and the lowest in ABRh (-) non-smokers. It was found that there were significant differences in the participants’ blood count parameters depending on blood type and smoking status. This may imply that ARh (+) individuals who smoke have higher parameters than those who have other blood groups and do not smoke, which may be beneficial in predicting the risk of chronic inflammation-related diseases. © 2023 Ondokuz Mayis Universitesi. All rights reserved.
COMPLEMENTARY AND ALTERNATIVE MEDICINE AWARENESS IN CANCER PATIENTS RECEIVING CHEMOTHERAPY
(Verduci International, 2020) Inci, H.; Inci, F.
Objective: We aimed at investigating the knowledge and attitudes of cancer patients who underwent chemotherapy about Complementary and Alternative Medicine (CAM). Patients and Methods: 306 cancer patients filled the CAM questionnaire. The patients were evaluated in terms of frequency of CAM use and CAM type, source of information, and reason for use and some other factors. Results: 92.8% of the patients had knowledge about CAM. 63.4% of them used one of the CAM methods. The patients generally used the CAM method thinking it may provide additional benefit to cancer treatments. Conclusions: It was observed that the rate of CAM use among the cancer patients were high. The patients obtained the information about CAM mostly through the media. Education level, disease stage, and place of residence were the independent predictive factors for the CAM use. They tended to use phytotherapy more often than other applications due to the fact that it has been used in our country for years. © 2020, Verduci International. All rights reserved.
COMPLEMENTARY AND ALTERNATIVE MEDICINE AWARENESS IN CANCER PATIENTS RECEIVING CHEMOTHERAPY
(Verduci Publisher, 2020) Inci, H.; Inci, F.
Objective: We aimed at investigating the knowledge and attitudes of cancer patients who underwent chemotherapy about Complementary and Alternative Medicine (CAM). Patients and Methods: 306 cancer patients filled the CAM questionnaire. The patients were evaluated in terms of frequency of CAM use and CAM type, source of information, and reason for use and some other factors. Results: 92.8% of the patients had knowledge about CAM. 63.4% of them used one of the CAM methods. The patients generally used the CAM method thinking it may provide additional benefit to cancer treatments. Conclusions: It was observed that the rate of CAM use among the cancer patients were high. The patients obtained the information about CAM mostly through the media. Education level, disease stage, and place of residence were the independent predictive factors for the CAM use. They tended to use phytotherapy more often than other applications due to the fact that it has been used in our country for years.
Depression, anxiety and coping strategies in cancer patients: A case control study
(Ankara Yildirim Beyazit University, 2019) Ersoy, S.; Inci, H.; Inci, F.; Engin, V.S.; Adahan, D.
Objectives: Psychiatric disorders frequently accompany chronic diseases especially cancer. The aim of this study was to investigate the depression and anxiety levels and the coping strategies in cancer patients. Materials and Methods: This was a case control study conducted in Karabuk University Research Hospital (KURH) between January 2018 and December 2018. Case group constituted of patients with an established diagnosis of cancer and control group included healthy individuals. Coping Strategies Questionnaire (COPE), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were performed for all participants. Statistical analyzes were carried out using Minitab 17 Statistical Software. Case versus control comparison for continues variables was conducted using Mann Whitney U test. Degree of relationship between continues variables were measured using Spearman's rank correlation. Chi-Squared test was used to evaluate cross tabulated categorical data. Results: 94 individuals were included in the study. Both cancer and control groups consisted of 23 males and 24 females. Mean age was found 59.77±12.01 years for cancer patients and 59.06±12.36 for control group. BDI and BAI scores of the patients were significantly higher compared to healthy individuals. Considering the cut-off values; 60% (28/47) of the cancer patients were found depressed and 62% (29/47) of them were found to have anxiety while in the control group both the depression and anxiety prevalence was 28% (13/47) (p=0.004 and p=0.002 respectively). Both groups were similar regarding the coping strategies total score (p=0.779). Turning to religion, humor, mental disengagement, denial and substance use were seen more frequently in cancer patients compared to control group (p=0.004, p=0.001, p=0.005, p=0.001 and p=0.004 respectively); whereas active coping, restraint coping, acceptance and behavioral disengagement were significantly more frequent in control group (p=0.001, p=0.039, p=0.026 and p=0.055 respectively). Humor, mental disengagement, denial and substance use were positively correlated with BDI scores (r=0.30 p=0.003, r=0.38 p=0.001, r=0.29 p=0.004, r=0.22 p=0.03 respectively). Turning to religion, humor, mental disengagement and substance use were positively correlated with BAI scores (r=0.24 p=0.015, r=0.25 p=0.013, r=0.31 p=0.001, r=0.23 p=0.024 respectively). Conclusion: The results of the current study revealed that cancer patients had higher levels of depression and anxiety compared to healthy individuals and they had higher risk of being depressed or anxious. Furthermore, the patients developed different strategies in order to cope with the burden of this catastrophic disease. Therefore, cancer is a multifaceted condition which must be approached in a multidimensional manner, by taking psychological features of each individual into account. © 2019 Ankara Yildirim Beyazit University. All rights reserved.
The effects of intermittent fasting on nighttime blood pressure levels
(Ondokuz Mayis Universitesi, 2022) Yilmaz, Yücel, A.H.; Adar, A.; Korkut, B.; Kalem, P.; Inci, H.; Adahan, D.
Hypertension, a preventable disease with a high prevalence, is frequently seen in obese patients with cardiovascular risk factors. Our study aimed to investigate the effect of an intermittent fasting regimen on nighttime blood pressure levels. Patients who applied to Karabuk University Faculty of Medicine Training and Research Hospital Cardiology and Family Medicine Polyclinic between January and March 2021 and were followed up for 24 hours on an outpatient basis were included in this self-controlled interventional study. Patients underwent a second 24-hour Holter blood pressure follow-up after one month of diet, and the results were compared. The study was conducted with 30 subjects who adhered to a one-month intermittent fasting regimen. 63.3% of the patients were male, and the mean age was 54.60 ± 9.71 years. One month later, 13 patients whose nighttime blood pressure improved were assigned to Group 1 and 17 patients to Group 2. There was no important variance between the groups in terms of gender, age, height, waist circumference and BMI (p=0.609, p=0.105 and p=0.087, in order of). Mean VA and BSA were considerably lower in Group 2 (p=0.027 and p=0.045, in order of). HT duration was longer in Group 1 (p=0.001). There was no important variance between the groups in terms of smoking, alcohol use, average daily sleep time, salt intake awareness and exercise habits. The rate of snacking habits in Group 2 was statistically considerably higher (p=0.033). Intermittent fasting may be beneficial in preventing nocturnal hypertension. © 2022 Ondokuz Mayis Universitesi. All rights reserved.
The effects of smoking cessation on the ratios of neutrophil/lymphocyte, platelet/lymphocyte, mean platelet volume/lymphocyte and monocyte/high-density lipoprotein cholesterol
(2023) Inci, H.; Besler, M.S.; Inci, F.; Adahan, D.
The amount of smoking, level of smoking addiction and smoking cessation have effects on blood cells, blood lipid levels, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV)/lymphocyte ratio (MPVLR) and monocyte/high- density lipoprotein (HDL) ratio (MHR). Methods In this self-controlled experimental study, we included individuals who applied to a smoking cessation clinic and quit smoking. Their sociodemographic and clinical characteristics, the amount of cigarettes consumed (pack/year), their Fagerstrom test for nicotine dependence (FTND) results, haemogram values before and 6 months after quitting smoking, NLR, PLR, MPVLR, MHR and blood lipid levels before and after the treatment were compared retrospectively. Results The mean (SD) age of the 239 individuals who participated in the study was 41.7 (10.9) years and 55.2% of them were women. Their mean FTND score was 7.06 (2.0), and most of them (47.7%) had a very high level of addiction. After the smoking cessation treatment, their neutrophil, platelet, MPV, red cell distribution width, platelet distribution width (PDW), cholesterol, triglyceride, low- density lipoprotein, NLR, PLR, MPVLR, MHR and HDL values increased (p<0.05). The amount of smoking and level of dependence were negatively correlated with HDL, and positively correlated with other parameters. Conclusion After smoking cessation, in addition to dyslipidaemia, the NLR, PLR, MPVLR and MHR values also decreased, and the difference was found to correlate with the level of addiction and the amount of smoking.
ESTİMATİON OF GENETİC AND ENVİRONMENTAL PARAMETERS AFFECTİNG PRODUCTİVİTY İN MORKARAMAN SHEEP AND ECONOMİC EVALUATİON OF PARAMETERS
(Society for Innovative Agriculture, University of Agriculture, 2021) Karadavut, U.; Bahadir, B.; Karadavut, V.; Simsek, G.; Inci, H.
This study was carried out to protect the continuity of productivity in morkaraman sheep raised in Turkey and determine their economic importance. Morkaraman sheep are concentrated in the Eastern Regions of the country. The province of Bingöl, where the study was conducted, is located in this region and has an important morkaraman population. The study was carried out between 2008-2018. Sixty-eight morkaraman sheep were used during the study period out of 317 lambing lambs. In the study, the total number of lambs born per sheep (TNLBS), the number of weaned lambs (NWL), the weights of the lambs weaned per sheep (WLWS) and the total weight of the lambs weaned in the first period (TWLWFP) were determined. In addition, Additive genetic variance, Error variance, Phenotypic variance, Heritability and Ratio of error variation were determined for these variables. As a result, the correlation between the examined variables was significant and positive, except for the relationship between TNLBS and TWLWFP. The relationship between these two variables was significant but negative. Significant changes were also observed in terms of genetic parameters. It was concluded that the economic aspects of the examined variables should not be ignored in terms of sustainability. © 2021 Society for Innovative Agriculture, University of Agriculture. All Rights Reserved.
EVALUATION OF PROGNOSIS, MORTALITY AND PLATELET INDEXES, PLATELET/LYMPHOCYTE AND NEUTROPHIL/LYMPHOCYTE RATIOS OF PALLIATIVE CARE PATIENTS
(Ankara Yildirim Beyazit University, 2023) Tapsiz, E.; Inci, H.; Kalem, P.; Sunay, D.
Objectives: In this study, it was aimed to evaluate the clinical significance of platelet indices, platelet, neutrophil, and lymphocyte values, as well as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) values and their relationship with mortality in palliative care patients. Materials and Methods: The data of 464 patients in the palliative care service were analyzed retrospectively. Sociodemographic characteristics of the patients, diagnosis, length of stay in the service, the way they were admitted to the palliative service and the way they were discharged from the palliative service, hospitalization and hematological parameters were recorded. Results: The mean age of the 464 patients included in the study was 75.15±13.63 years. It was seen that 68.30% of the patients were alive during the time period they were included in the study. When the admission and discharge blood values of the patients who died and the patients who survived were compared, the WBC and neutrophil values of the patients who died were found to be higher than the patients who survived, while the platelet and lymphocyte values of the patients who died were found to be lower. While admission and discharge NLR values, admission PLR values, discharge MPV values and discharge PDW values were found to be significantly higher in patients who died than in patients who survived, discharge PCT value was found low. Conclusion: Leukocytosis, thrombocytopenia, lymphopenia, and neutrophilia were dominant in the hematological parameters of the patients who died compared to the patients who survived. In contrast, the admission PLR value was found to be higher in patients who died than the patients who survived. © Annals of Translational Medicine. All rights reserved.
IS LOW SERUM VITAMIN D LEVEL ASSOCIATED WITH CANCER?
(Verduci Publisher, 2020) Inci, F.; Inci, H.; Karatas, F.; Adahan, D.
Objective: The aim of this study is to determine the importance of serum Vitamin D (VD) levels in cancer pathogenesis and to investigate its relationship with cancer subtypes. Patients and Methods: This study included 4914 individuals, 1027 cancer patients and 3887 healthy subjects. The cancer patients were divided into five groups by cancer subtypes. The cancer patients and those in the control group were compared in terms of serum VD levels. Results: In the patients with cancer, the mean serum VD level was found to be significantly lower than that in the control group (16.1 +/- 10.6 ng/mL vs. 19.6 +/- 10.4 ng/mL, p = 0.000). The VD levels were higher in breast cancer (BC) group than those in other cancer groups. The mean serum VD level was significantly lower in the BC group compared to the control group (18.1 +/- 11.3 ng/mL vs. 19.6 +/- 10.4 ng/mL, p = 0.004). In the ROC analysis, the cut-off VD value was determined as 15.2 ng/mL between those with and without cancer (area 0.634, OR: 95% CI 0.612-0.656, p = 0.000). VD <15.2 ng/mL was independently associated with cancer (OR, 2.096; 95% CI: 1.595 - 2.756, p = 0.000). Moreover, the decreased VD level was found to be independently associated with the increased cancer risk (OR, 1.048; 95% CI: 1.032- 1.065, p = 0.000). Conclusions: Although there was no difference in VD levels among the cancer patients and there was less difference in the BC patients compared to the healthy individuals, the VD level was significantly lower in all cancer patients compared to healthy people. In addition, there was an independent positive association between VD levels and cancer, with the VD values below 15.2 ng/mL increasing the cancer risk.
Pain catastrophizing, depression, and anxiety in fibromyalgia patients
(Ondokuz Mayis Universitesi, 2023) Inci, H.; Inci, F.
Psychiatric findings may be seen in Fibromyalgia (FM) patients. We aimed to evaluate the relationship between anxiety, depression, and pain catastrophizing in FM patients and normal individuals. The study group consisted of FM patients and a healthy control group. Socio-demographic data form, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Visual Analogue Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), and Pain Catastrophizing Scale (PCS) were administered to the participants. It was evaluated whether there was a statistical difference between the groups in terms of BDI, BAI, PCS, VAS, and FIQ. Of the 178 patients in our study, 85 were FM patients and 93 were control groups. The BDI, BAI, PCS, PCSH (PCS Helplessness), PCSM (PCS Magnification), and PCSR (PCS Rumination) were found to be higher in FM patients compared to the control group. The FM patients were found to have moderate depression according to the BDI score (18.7±10.6) and moderate anxiety according to the BAI score (16.5±9.9). There was a positive correlation between BDI and BAI, FIQ and VAS, PCS and BDI, BAI and FIQ, and BAI and FIQ. It was found that the FM patients had “moderate” depression and anxiety, and their level of pain catastrophizing increased with the increase in depression and anxiety severity. © 2023 Ondokuz Mayis Universitesi. All rights reserved.
Wet cupping therapy improves health related quality of life: A self-controlled interventional study
(Ankara Yildirim Beyazit University, 2019) Ersoy, S.; Inci, H.; Sunay, D.; Kayis, S.A.; Engin, V.S.; Benli, A.R.
Objectives: Wet cupping therapy is an ancient treatment method which has been an integral part of Traditional Anatolian Medicine. In the current study we aimed to assess the efficacy of wet cupping therapy on health-related quality of life in healthy volunteers. Materials and Methods: This was a single arm pre-test and post-test interventional study conducted in Traditional and Complementary Medicine Clinic of Karabuk Education and Research Hospital between August 1, 2017 and August 1, 2018. Fifty-three healthy volunteers were enrolled in the study. They received three wet cupping therapy sessions once every month for three months (On 0, 30, and 60 days). WHOQOL-BREF-TR questionnaire was applied to all participants both before the sessions and after the third one. Wilcoxon signed rank test was employed to compare pre and post test scores. A p value <0.05 assumed to be statistically significant. All analyzes were carried out using Minitab 17 Statistical Software. Results: The study sample consisted of 26 female and 27 male subjects. Mean age was 43.68 ± 9.41 years. It was found 46.34 ± 9.78 years for females and 40.63± 8.43 years for males. Initial WHOQOLBREF- TR scores regarding general health (p<0.001) and the four domains which were physical (p<0.001), psychological (p<0.001), social relations (p<0.001) and the environmental domain (p<0.005) showed significant improvements after three WCT sessions Conclusion: Our results suggest that quality of life may be improved in healthy adults by wet cupping therapy. © 2019 Ankara Yildirim Beyazit University. All rights reserved.

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