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Öğe Calcium antagonists, digoxin, calcaemia and anaemia in heart failure(Scientific Publishers of India, 2017) Yildiz, S.S.; Dikerdem, D.; Benli, A.R.; Kalem, P.; Cikrikcioglu, M.A.Objective: To reveal that Calcium Antagonist (CA) use is associated with lower haemoglobin (Hb) and digoxin use is associated with higher Hb in Heart Failure (HF). Method: 223 chronic HF patients in acute decompensation phase were included in the study. Patients with comorbidities leading to anemia and those receiving blood transfusion or antianaemic treatment were excluded. Patients were classified into two groups as anemic and non-anemic groups. Two groups were compared retrospectively with demographics, clinical findings, medication use, echocardiography findings, complete blood count and biochemistry. Different independent variables between two groups were subjected to Multivariate Binary Logistic Regression Analysis (MBLRA) under the dependent variable anemia. Multivariable linear Regression Analysis (RA) was also performed with the dependent variable of Hb. Results: MBLRA results showed that anemia was seen less frequently in digoxin users, whereas it was more frequent in the following conditions: CA use, chronic renal failure, lower AST, lower LDL cholesterol, lower triglyceride, lower Transferring Saturation Rate (TSR). RA results also showed that lower LDL cholesterol, lower eGFR, lower transferrin saturation rate, lower corrected calcium, female gender and CA use were associated with lower Hb; whereas, digoxin use was associated with higher Hb. Conclusions: Haemoglobin levels were found higher in digoxin users. CA use, lower corrected calcium and lower AST were associated with lower Hb in heart failure. These findings have not been reported so far. © 2017, Scientific Publishers of India. All rights reserved.Öğe The effect of ferritin, vitamin B12 and folic acid on pregnancy outcomes(E-Century Publishing Corporation, 2016) Kalem, P.; Benli, A.R.; Koroglu, M.; Benli, N.C.; Koyuncu, M.; Cesur, O.; Dane, P.B.K.Purpose: A reduction occurs in levels of some minerals and vitamins due to physiological adaptation during pregnancy, and this situation causes anemia in pregnancy. The aim of the present study was to evaluate the effect of ferritin, vitamin B12 and folate levels on outcomes of pregnancy in 3rd trimester pregnant women. Materials and Methods: This retrospective study included a total of 72 pregnant women in the third trimester of pregnancy. Vitamin and mineral analyses of the patients were applied. Patients were questioned in respect of whether or not iron and vitamin supplements were taken during pregnancy, the mode of delivery and the history of postpartum problems in infant. Results: As the number of children increased, so an increase was seen in the incidence of anemia. Of the mothers of newborns with medical problems, 60% had anemia. There was no statistically significant difference in the mean birth weight according to the presence or absence of maternal anemia. Anemia in pregnant women is defined as hemoglobin level below 11.0 g/dL in the first and third trimester and below 10.5 g/dL in the second trimester. No significant difference was determined in anemia status according to the mode of delivery. No difference in anemia was detected in infants, regardless of whether or not their mothers took vitamin and mineral supplements. Conclusion: Anemia in the third trimester has no effect on the mode or time of delivery, weight and general condition of the newborn. To decide the effect of anemia on the outcome of pregnancy, further studies with more participants are needed. © 2016, E-Century Publishing Corporation. All rights reserved.Öğe The effects of intermittent fasting on nighttime blood pressure levels(Ondokuz Mayis Universitesi, 2022) Yilmaz, Yücel, A.H.; Adar, A.; Korkut, B.; Kalem, P.; Inci, H.; Adahan, D.Hypertension, a preventable disease with a high prevalence, is frequently seen in obese patients with cardiovascular risk factors. Our study aimed to investigate the effect of an intermittent fasting regimen on nighttime blood pressure levels. Patients who applied to Karabuk University Faculty of Medicine Training and Research Hospital Cardiology and Family Medicine Polyclinic between January and March 2021 and were followed up for 24 hours on an outpatient basis were included in this self-controlled interventional study. Patients underwent a second 24-hour Holter blood pressure follow-up after one month of diet, and the results were compared. The study was conducted with 30 subjects who adhered to a one-month intermittent fasting regimen. 63.3% of the patients were male, and the mean age was 54.60 ± 9.71 years. One month later, 13 patients whose nighttime blood pressure improved were assigned to Group 1 and 17 patients to Group 2. There was no important variance between the groups in terms of gender, age, height, waist circumference and BMI (p=0.609, p=0.105 and p=0.087, in order of). Mean VA and BSA were considerably lower in Group 2 (p=0.027 and p=0.045, in order of). HT duration was longer in Group 1 (p=0.001). There was no important variance between the groups in terms of smoking, alcohol use, average daily sleep time, salt intake awareness and exercise habits. The rate of snacking habits in Group 2 was statistically considerably higher (p=0.033). Intermittent fasting may be beneficial in preventing nocturnal hypertension. © 2022 Ondokuz Mayis Universitesi. All rights reserved.Öğe EVALUATION OF PROGNOSIS, MORTALITY AND PLATELET INDEXES, PLATELET/LYMPHOCYTE AND NEUTROPHIL/LYMPHOCYTE RATIOS OF PALLIATIVE CARE PATIENTS(Ankara Yildirim Beyazit University, 2023) Tapsiz, E.; Inci, H.; Kalem, P.; Sunay, D.Objectives: In this study, it was aimed to evaluate the clinical significance of platelet indices, platelet, neutrophil, and lymphocyte values, as well as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) values and their relationship with mortality in palliative care patients. Materials and Methods: The data of 464 patients in the palliative care service were analyzed retrospectively. Sociodemographic characteristics of the patients, diagnosis, length of stay in the service, the way they were admitted to the palliative service and the way they were discharged from the palliative service, hospitalization and hematological parameters were recorded. Results: The mean age of the 464 patients included in the study was 75.15±13.63 years. It was seen that 68.30% of the patients were alive during the time period they were included in the study. When the admission and discharge blood values of the patients who died and the patients who survived were compared, the WBC and neutrophil values of the patients who died were found to be higher than the patients who survived, while the platelet and lymphocyte values of the patients who died were found to be lower. While admission and discharge NLR values, admission PLR values, discharge MPV values and discharge PDW values were found to be significantly higher in patients who died than in patients who survived, discharge PCT value was found low. Conclusion: Leukocytosis, thrombocytopenia, lymphopenia, and neutrophilia were dominant in the hematological parameters of the patients who died compared to the patients who survived. In contrast, the admission PLR value was found to be higher in patients who died than the patients who survived. © Annals of Translational Medicine. All rights reserved.
