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    Calcium antagonists, digoxin, calcaemia and anaemia in heart failure.
    (Allied Acad, 2017) Yildiz, Sati Sena; Dikerdem, Didem; Benli, Ali Ramazan; Kalem, Pinar; Cikrikcioglu, Mehmet Ali
    Objective: To reveal that Calcium Antagonist (CA) use is associated with lower haemoglobin (Hb) and digoxin use is associated with higher Hb in Heart Failure (HF). Method: 223 chronic HF patients in acute decompensation phase were included in the study. Patients with comorbidities leading to anemia and those receiving blood transfusion or antianaemic treatment were excluded. Patients were classified into two groups as anemic and non-anemic groups. Two groups were compared retrospectively with demographics, clinical findings, medication use, echocardiography findings, complete blood count and biochemistry. Different independent variables between two groups were subjected to Multivariate Binary Logistic Regression Analysis (MBLRA) under the dependent variable anemia. Multivariable linear Regression Analysis (RA) was also performed with the dependent variable of Hb. Results: MBLRA results showed that anemia was seen less frequently in digoxin users, whereas it was more frequent in the following conditions: CA use, chronic renal failure, lower AST, lower LDL cholesterol, lower triglyceride, lower Transferring Saturation Rate (TSR). RA results also showed that lower LDL cholesterol, lower eGFR, lower transferrin saturation rate, lower corrected calcium, female gender and CA use were associated with lower Hb; whereas, digoxin use was associated with higher Hb. Conclusions: Haemoglobin levels were found higher in digoxin users. CA use, lower corrected calcium and lower AST were associated with lower Hb in heart failure. These findings have not been reported so far.
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    The effect of blood urea nitrogen/creatinine and blood urea nitrogen/albumin ratios on the prognosis and mortality of patients in the palliative care service
    (Termedia Publishing House Ltd, 2022) Inci, Habibe; Kalem, Pinar; Adahan, Didem
    Introduction: In this study we aimed to evaluate the effects of the blood urea nitrogen/creatinine ratio (BUN/BCR) and the BUN/albumin ratio (BAR) on the prognosis and mortality in patients in the palliative care service.Material and methods: Patients in the palliative service were included in the study. Sociodemo-graphic data of the patients such as age, gender, chronic diseases, discharge from the service, length of stay in the service, BUN, creatinine, albumin, C-reactive protein (CRP), and haemogram parameters were recorded retrospectively from patient files and the hospital automation system. BCR and BAR values were calculated.Results: A total of 209 patients were included in the study. 57.4% of them were male, and 44.9% were >= 81 years of age. While 78.0% of the patients were discharged alive, 22.0% of them died. When the blood test results of the patients who were discharged from the palliative service alive and those who died were compared, it was seen that the CRP, BUN, BCR, and BAR levels were high, and the albumin levels were low in the patients who died. A positive correlation was ob-served between BCR and BAR levels in patients in the palliative service. It was observed that as BAR and BCR levels increased, the length of stay in the service, BUN, creatinine, and CRP levels increased, while albumin levels decreased.Conclusions: In our study, a positive correlation was found between BCR and BAR parameters, hospitalization time, and mortality status of patients in the palliative service with various systemic diseases. In this case, it can be said that the BCR and BAR ratios have value in predicting the out-comes and mortality in patients.
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    The effect of ferritin, vitamin B12 and folic acid on pregnancy outcomes
    (E-Century Publishing Corp, 2016) Kalem, Pinar; Benli, Ali Ramazan; Koroglu, Mustafa; Benli, Neriman Cetin; Koyuncu, Murat; Cesur, Ozkan; Dane, Pakizer Banu Kilicoglu
    Purpose: A reduction occurs in levels of some minerals and vitamins due to physiological adaptation during pregnancy, and this situation causes anemia in pregnancy. The aim of the present study was to evaluate the effect of ferritin, vitamin B12 and folate levels on outcomes of pregnancy in 3rd trimester pregnant women. Materials and Methods: This retrospective study included a total of 72 pregnant women in the third trimester of pregnancy. Vitamin and mineral analyses of the patients were applied. Patients were questioned in respect of whether or not iron and vitamin supplements were taken during pregnancy, the mode of delivery and the history of postpartum problems in infant. Results: As the number of children increased, so an increase was seen in the incidence of anemia. Of the mothers of newborns with medical problems, 60% had anemia. There was no statistically significant difference in the mean birth weight according to the presence or absence of maternal anemia. Anemia in pregnant women is defined as hemoglobin level below 11.0 g/dL in the first and third trimester and below 10.5 g/dL in the second trimester. No significant difference was determined in anemia status according to the mode of delivery. No difference in anemia was detected in infants, regardless of whether or not their mothers took vitamin and mineral supplements. Conclusion: Anemia in the third trimester has no effect on the mode or time of delivery, weight and general condition of the newborn. To decide the effect of anemia on the outcome of pregnancy, further studies with more participants are needed.