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    CLINICAL FINDINGS AND PROGNOSIS OF HOSPITALIZED ELDERLY COVID-19 PATIENTS
    (Turkish Geriatrics Soc, 2021) Bozan, Oner; Atis, Seref Emre; Cekmen, Bora; Kocer, Mehmet Taylan; Koca, Yayunelim; Karaaslan, Edip Burak; Senturk, Mucahit
    Background: SARS-CoV-2 has caused an outbreak all over the World. Age is the most important factor for mortality. However, it is not known exactly why SARS-CoV-2 infections are more severe and fatal in the elderly population. We examined the clinical course and the causes of increasing mortality in all hospitalized patients diagnosed with COVID-19 over 65 years of age. Methods: Hospitalized elderly patients diagnosed with COVID-19 were examined in this retrospective observational study. The blood results, length of stay, comorbid diseases, admission symptoms, clinical results and demographic data of the patients were recorded. It was examined whether there was a significant difference between surviving and non-surviving patients in terms of comorbid diseases and symptoms. The effects of these parameters on the 30-day mortality alone were investigated. Results: A total of 263 patients (125 males) were included in the study. Cough (53.2%) followed by dyspnea (35.7%) were the two most common symptoms. There was no statistically significant difference age or sex distribution between survivor and nonsurvivor patients. Patients with dyspnea had a significantly lower survival rate compared to patients who did not have dyspnea at presentation and patients who have chronic obstructive pulmonary disease and cerebrovascular disease were associated with a significantly increased risk of mortality Conclusions: It has been shown that there is a significant increase in the risk of mortality in COVID-19 patients with chronic obstructive pulmonary disease and cerebrovascular diseases. Additionally, Dyspnea, as an admission symptom, were found to have an effect on mortality and clinical outcomes in our study.
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    Evaluation of brain oxygenation by near infrared spectroscopy in healthcare professionals using surgical and ffp2/n95 masks
    (2022) Bozan, Öner; Atıs, Seref Emre; Çekmen, Bora; Karakısa, Halit; Karaaslan, Edip Burak; Ferhatlar, Mehmet Esat; İslam, Mehmet Muzaffer
    Aim: The present study aimed to detect changes in brain oxygenation associated with the use of surgical and FFP2/N95 masks using the near infrared spectroscopy (NIRS) method. Material and Methods: Volunteers wearing surgical masks were asked to sit upright for 30 minutes. Cerebral oxygen saturation values were measured at the 1st, 5th, and 30th minutes (group 1). The mask wearers were requested to return at the same time on the day following this procedure. In group 2, serial cerebral oxygen saturation values (SpO2) were obtained at the same time intervals as in group 1, but while the subjects were wearing FFP2/N95 masks. Results: A statistically significant difference was found between the groups in the comparison of the values measured using NIRS at the 1st, 5th, and 30th minutes in group 1. According to the post-hoc analysis, this difference was due to discrepancies in NIRS measurements at the 1st minute and 30th minute and at the 5th minute and 30th minute. No statistically significant difference was found between the groups in the comparison of the values measured using NIRS at the 1st, 5th, and 30th minutes in group 2. Conclusion: Neither surgical nor FFP2/N95 masks caused a clinically significant negative difference in brain oxygenation.
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    A new biomarker in the differential diagnosis of epileptic seizure: Neurogranin
    (W B Saunders Co-Elsevier Inc, 2022) Kalkan, Asim; Demirel, Ahmet; Atis, Seref Emre; Karaaslan, Edip Burak; Ferhatlar, Mehmet Esat; Senturk, Mucahit
    Aim: The aim of this study was to determine the level of serum NGRN in epilepsy patients presenting at the Emergency Department with complaints of an epileptic seizure, and to thus evaluate the utility of this biomarker in the differentiation of epilepsy and PNES patients from each other. Material methods: The study included patients aged >18 years who had experienced an epileptic seizure or were experiencing an epileptic seizure proven with EEG. All patients with brain disease of structural or infectious cause were excluded from the study (dementia, stroke, intracranial mass, meningitis, encephalitis, Creutzfeldt-Jacobs disease, abscess, etc). Patients were also excluded if they had traumatic brain injury or a severe systemic disease such as sepsis, which was thought to impair brain blood flow. The control group was formed of completely healthy volunteers. Results: Evaluation was made of a total of 49 patients, comprising 19 (38.78%) males and 30 (61.22%) females, and a control group of 53 healthy volunteers comprising 28 (52.83%) males and 25 (47.17%) females. The serum neurogranin value was median 184.16 ng/dl (range: 110.1-1172.98) in the patient group and 97.90 ng/dl (range: 73.71-282. 11) in the control group. The serum neurogranin value was determined to be statistically significantly higher in the patient group than in the control group (p < 0.005). Conclusion: The differential diagnosis of ES from PNES remains a challenging situation for emergency service physicians. Based on the findings of this study, it can be said that the serum NRGN level is high in patients who have experienced an epileptic seizure. Therefore, this new biomarker can be considered for use in the differential diagnosis of epileptic seizure and PNES. (c) 2022 Elsevier Inc. All rights reserved.