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The relationship between reproductive hormone levels and osteoporosis
(2020) Eroğlu, Semra; Karataş, Gulsah
Objectives: Changes in serum levels of follicle-stimulating hormone (FSH) and estradiol (E2) due to menopause arethe some of the most important factors for osteoporosis (OP). The aim of this study was to evaluate the relationshipbetween bone mineral density (BMD) and reproductive hormone levels in postmenopausal women.Methods: A total of 144 postmenopausal women were divided into two groups according to their BMD, as obtainedusing dual-energy X-ray absorptiometry; 72 patients with low BMD and 72 healthy subjects. Fasting blood sampleswere obtained from all participants for serum hormone levels, which were compared between the two groups.Results: The FSH levels were significantly higher in the low BMD group (49.76±27.61 IU/L vs. 57.30±24.83 IU/L,p=0.001), and serum E2 levels were statistically lower in the low BMD group (39.25±22.11 pg/mL vs. 30.12±18.16 pg/mL, p=0.046). The time elapsed after the onset of menopause was longer in the low BMD group (p=0.002).Conclusion: The low E2 and high FSH levels after the onset of menopause were associated with low BMD in postmenopausal women. According to these findings, considering the higher risk of OP in patients with low E2 and highFSH levels, randomized-prospective studies should be conducted to determine whether prophylactic treatment shouldbe given to this group.