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Öğe Awareness and Knowledge of SARS-CoV-2 Infection among Dental Professionals According to the Turkish National Dental Guidelines(Mdpi, 2021) Karayurek, Fatih; Yilmaz cirakoglu, Neslihan; Guelses, Aydin; Ayna, MustafaThe objective of the current survey was to assess the awareness of the dental professionals according to the principals described by the Turkish Dental Association (TDA). A questionnaire including the socio-demographic data, specialties/academic degree, institutions/affiliations, the knowledge about COVID-19, the number of patients examined and dental treatments performed during the COVID-19 pandemic, the knowledge of protection based on the guidelines described by TDA, contamination with COVID-19 and the psychological complaints has been used. A total of 947 (63.1%) dentists enrolled the study. The results showed satisfactory knowledge about the COVID-19 etiology, mode of transmission and the pre-procedural cautions as the majority of them had a fair level of knowledge with significantly higher knowledge among specialized respondents. The participants have also recorded a good judgment towards performing the emergency dental treatment during the current COVID-19 pandemic which corresponds with the guidelines determined by TDA. Considering the updates on the transmission of COVID-19 and protective strategies, there is an urgent need for improvement of dentists' knowledge about risk assessment via training programs. The incidence of positive testing among dental professionals also necessitates immediately testing of asymptomatic Turkish dental professionals.Öğe Combining platelet rich fibrin with different bone graft materials: An experimental study on the histopathological and immunohistochemical aspects of bone healing(Churchill Livingstone, 2019) Karayurek, Fatih; Kadiroglu, Ela Tules; Nergiz, Yusuf; Akcay, Neslihan Coskun; Tunik, Selcuk; Kanay, Berna Ersoz; Uysal, ErsinAim: The current study was based on the hypothesis that the use of PRF with bone graft materials might increase bone regeneration and focus on the histopathological and immunohistochemical aspects following application of PRF with autogenous graft, xenograft and B-TCP in a rabbit model. Material and methods: This study was performed on the twenty-eight male New Zealand divided into four group. Two defects with a diameter 10 mm were opened in calvarium. After PRF preparation, right defects were evaluated as empty defect or graft group, and left defects were evaluated as PRF test group. All animals were sacrificed at the end of 8 weeks and specimens were examined histopathologically and immunohistochemically. Results: The most superior histopathological results were obtained in the autograft group. The combination of beta-TCP-PRF could not provide superiority over the beta-TCP group. The immunohistochemical results showed that, in the PRF/BTCP group, the expression of osteopontin and osteonectin was relatively higher compared to the only-BTCP group. Conclusion: In terms of new bone formation, autograft combined with PRF yielded superior results but the combination of beta-TCP-PRF had no effect compared to the only-BTCP group. However, further experimental and clinical studies might be beneficial to clarify the exact mechanism and results of combining PRF with bone grafts on bone healing process. (C) 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.Öğe A Deep Learning Approach for Classification of Dentinal Tubule Occlusions(Taylor & Francis Inc, 2022) Duru, Anday; Karas, Ismail Rakip; Karayurek, Fatih; Gulses, AydinThis study aimed to develop a novel deep learning model for reliable quantification of dentinal tubule occlusions instead of manual assessment techniques, and the performance of the model was compared to other methods in the literature. Ninety-six dentin samples were cut and prepared with desensitizing agents to occlude dentinal tubules on different levels. After obtaining images via scanning electron microscope (SEM), 2793 single dentinal tubule images with 48 x 48 resolution were segmented and labeled. Data augmentation techniques were applied for improvement in the learning rate. The augmented data having a total of 10700 images belonging to five classes were used as the network training dataset. The proposed convolutional neural network (CNN) is a class of deep learning model and was able to classify the degree of dentinal tubule occlusions into five classes with an overall accuracy rate of 90.24%. This paper primarily focuses on developing a CNN architecture for detecting the level of dentin tubule occlusions imaged by SEM. The results showed that the proposed CNN architecture is an immensely successful alternative and allowed for objective and automatic classification of segmented dentinal tubule images.Öğe DEPRESSION AND ANXIETY LEVELS IN A GROUP OF ELDERLY WITH TEMPOROMANDIBULAR DISORDERS(Gunes Kitabevi Ltd Sti, 2021) Cebi, Ahmet Taylan; Yilmaz, Nihat; Karayurek, Fatih; Gulses, AydinIntroduction: The objective of this study was to assess stress and anxiety in a sample of elderly patients suffering from temporomandibular joint disorders who did not have previously diagnosed emotional disturbances. It is well known that patients presenting with temporomandibular joint disorders are more commonly affected by anxiety and depression. However, there is a lack of data regarding the prevalence of undiagnosed anxiety and emotional stress disorders among elderly patients with temporomandibular joint disorders. Materials and Method: Clinical examination was performed using Research Diagnostic Criteria (Axis I). Patients with previously diagnosed and managed psychiatric and psychological disorders were excluded. Magnetic resonance imaging findings were also used to confirm the diagnosis. Beck Depression Inventory and Beck Anxiety Inventory forms were obtained to assess stress and anxiety levels. Results: A total of 125 patients (103 [82.4%] women and 22 [17.6%] men) aged 60 to 87 (71.89 +/- 10.39) years were included. The highest depression and anxiety scores were found among patients suffering from bruxism, followed by those with disc displacement without reduction and myofascial pain syndrome. All the patients showed significantly elevated depression levels. Conclusion: The emotional health status of elderly patients with intraand extra-articular temporomandibular joint disorders should be attentively assessed.Öğe Evaluation of the effects of bone morphogenetic protein-2 on the healing of bone calvarial defects in ovariectomized rats(Tubitak Scientific & Technological Research Council Turkey, 2020) Kadiroglu, Ela Tules; Karayurek, Fatih; Akbalik, Mehmet ErdemBone morphogenetic proteins (BMPs) are often used with bone grafts for bone regeneration. The aim of this study was to evaluate the effect of demineralized freeze-dried bone allografts and externally applied rhBMP-2 on bone healing in experimentally generated defects in the calvarium of ovariectomized and nonovariectomized rats via histological and immunohistochemical assays. The current study was carried out on 42 female Wistar rats. After ovariectomy was performed in half of the rats, the rats were divided into three groups: control, allograft, and allograft + BMP. An experimental defect with a diameter of 4 mm was created unilaterally in the parietal bone using a trephine dental drill and a physiodispenser with saline. All animals were euthanized at the end of week 8, and bone tissues were analyzed histologically and immunohistochemically. The allografts produced better results in terms of calvarial defect healing in both the ovariectomized and nonovariectomized groups compared to the control group in enhancing bone healing, whereas BMPs combined with allografts had no positive effect on new bone formation. The allografts and BMPs applied in both groups produced fibrous tissues rather than new bone tissue. Further comprehensive studies on the effectiveness of BMPs in the formation of new bone tissue should be conducted in animals with estrogen deficiency.
