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Öğe Attenuation of Antibody Response and Elevation of CD4+CD25+Foxp3+ Treg cell Frequency During Chronic Liver Fibrosis(Wiley, 2017) Canpolat, Esra; Karaca, Mete; Kayhan, Basak; Kayhan, Burcak; Bayindir, Yasar; Yilmaz, Sezai[No abstract available]Öğe A bioactive product lipoxin A4 attenuates liver fibrosis in an experimental model by regulating immune response and modulating the expression of regeneration genes(Aves, 2019) Kurtoglu, Elcin Latife; Kayhan, Basak; Gul, Mehmet; Kayhan, Burcak; Kayhan, Meral Akdogan; Karaca, Zeynal Mete; Yesilada, ElifBackground/Aims: Lipoxin A4 (LXA4), an anti-inflammatory lipid mediator, regulates leukocyte cellular activity and activates gene transcription. The therapeutic effect of LXA4 on liver fibrosis and its mechanism on the immune system are largely unknown. Because the regenerative capacity of hepatocytes in acute and chronic liver failure models of mouse increases by silencing MKK4, we aimed to investigate the effect of parenteral administration of LXA4 on the genes responsible for regeneration of liver, namely MKK4, MKK7, and ATF2, and visualize the therapeutic effects in an experimental model. Materials and Methods: Fibrosis was induced in mice by administration of thioacetamide (TAA). LXA4 was administered during the last two weeks of fibrosis induction. The fibrosis level was measured by Knodell scoring. The liver function was measured by analyzing serum ALT, AST, and AP levels. Expression levels of genes responsible for liver fibrosis (TGF-alpha) and cell regeneration (MKK4, MKK7, and ATF2) have been measured by RT-PCR analysis. Inflammatory and anti-inflammatory cytokine levels were measured in serum samples and liver homogenates by Enzyme Linked Immunosorbent Assay (ELISA). Ultrathin sections were examined using a transmission electron microscope and analyzed. Results: We observed significant healing in liver of the LXA4-treated group, histologically. This finding was in parallel with reduction of serum ALT, AST, but not AP levels. TGF-alpha and MKK4 expressions were significantly reduced in the LXA4-treated group. Administration of LXA4 caused significant elevation of IL-10 in systemic circulation; however, that elevation was not detected in liver homogenates. Nevertheless, significant reductions in TNF-alpha and IL-17 have been observed. Conclusion: The anti-inflammatory effect of LXA4 maintains the regenerative capacity of liver during fibrosis in an experimental liver fibrosis model. LXA4 may be therapeutically beneficial in liver fibrosis.Öğe Dose-dependent effects of kefir on colitis induced by trinitrobenzene sulfonic acid in rats(Wiley, 2019) Sevencan, Nurhayat Ozkan; Isler, Mehmet; Kapucuoglu, Fatma Nilgun; Senol, Altug; Kayhan, Burcak; Kiztanir, Sefa; Kockar, Muhammed CemEvidence suggests that gut microbiota dysbiosis plays a critical role in the initiation and promotion of inflammatory bowel disease (IBD). Kefir is a fermented dairy product including yeast and bacterial species. We aimed to investigate the effect of kefir on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats using two different doses. Fifty-four Wistar rats were divided into six groups. For 14 days, the normal control and colitis control groups were given tap water, kefir10 control, kefir10 colitis, and kefir30 control, and the kefir30 colitis groups were given phosphate-buffered saline containing 10% or 30% kefir, respectively, instead of tap water. Colitis was induced by intracolonically administrating TNBS in the colitis control, kefir10 colitis, and kefir30 colitis groups. On the 14th day, the rats were sacrificed. The weights and lengths of the colons were measured and macroscopically evaluated, and the distal 10 cm segments were subjected to a histopathological examination. The incidence of bloody stool and diarrhea in the kefir10 colitis group was found to be less than the colitis control and kefir30 colitis groups. The colonic weight/length ratio in the kefir10 colitis group was lower than that in the colitis control and kefir30 colitis groups. We detected that the 10% kefir treatment reduced TNBS-induced macroscopic colonic damage, while it was exacerbated by the 30% kefir treatment. No significant difference was observed between the colitis groups in terms of microscopic colonic damage scoring. These results indicate that kefir, with a careful dose selection, may be a useful agent in the treatment of IBD.Öğe THE IMPORTANCE OF ANTIOXIDANT STATUS IN GASTRIC INTESTINAL METAPLASIA(Soc Medical Biochemists Serbia, 2021) Danis, Nilay; Ozkan, Aysegul; Karatas, Fatih; Cakici, Cagri; Yigitbasi, Turkan; Sevencan, Nurhayat; Kayhan, BurcakBackground: Oxidative stress status in different cancer types was investigated before, but not studied in gastric intestinal metaplasia to the best of our knowledge. Purpose of this study is to examine whether there is a difference between oxidative stress status in patients with intestinal metaplasia (IM) compared to individuals without IM, we compared the serum levels of disulfide (SS), total thiol (TT) and native thiol (NT). Methods: This was a prospective, non-randomized case-control study including 67 patients with histopathologically confirmed IM and 60 individuals demographically matched in terms of age, gender, BMI, smoking status, and chronic diseases as control group. Results: The mean NT, TT and NT to TT (NT/TT) ratios were statistically significantly higher in IM group compared to controls ((351.71 +/- 81.9 mu mol/L vs. 271.82 +/- 54.13 mu mol/L, p=0.000), (391.5 +/- 92.69 mu mol/L vs. 308.59 +/- 55.53 mu mol/L, p=0.000) and (0.89 +/- 0.6 vs. 0.87 +/- 0.29, p=0.022), respectively). The mean SS to TT (SS/TT) ratio was significantly lower in IM group than control group (0.050 +/- 0.31 vs. 0.060 +/- 0.014, P=0.022). Median SS and mean SS/NT ratio was similar in both groups (16.3 (3.3-78) vs. 18.3 (10-32.7), p=0.271 and 0.055 +/- 0.041 vs. 0.070 +/- 0.019, p=0.068, respectively). In ROC analysis, cut off value of SS/NT for IM was found 0.062, in regression analysis, SS/NT <0.062 was found as an independently prognostic marker for IM (OR, 2.38; 95%CI: 1.168-4.865, P=0.017). Conclusions: SS/NT ratio lower than 0.062 was found as an independently prognostic marker for IM. This ratio could help to distinguish which patients should be followed closely for gastric cancer.Öğe Linagliptin-related pancreatitis in a diabetic patient with biliary calculus A case report(Lippincott Williams & Wilkins, 2018) Sevencan, Nurhayat Ozkan; Ozkan, Aysegul Ertinmaz; Kayhan, BurcakRationale: Dipeptidyl peptidase-4 inhibitors are commonly used drugs for the treatment of type 2 diabetes mellitus. While acute pancreatitis cases induced by saxagliptin, sitagliptin, and vildagliptin (all of which are members of the dipeptidyl peptidase-4 group) have been reported, there is no clear evidence suggesting that linagliptin may cause pancreatitis, and information in this regard is limited to a few studies. Moreover, no pancreatitis cases have been reported that were directly associated with linagliptin. Patient concerns: We present a case of linagliptin-related pancreatitis in a 79-year-old male diabetic patient with biliary calculi. The patient, who was diagnosed with acute pancreatitis 4 months after initiating linagliptin 5mg/d treatment, was admitted to our hospital. Diagnoses: The patient's pancreatic enzymes were high. Ultrasonography showed multiple biliary calculi, and abdominal computed tomography showed edematous pancreatitis. Interventions: Linagliptin was discontinued and clinical improvement was achieved with standard acute pancreatitis treatment. Outcomes: This is the 1st case report suggesting that linagliptin might be associated with the risk of pancreatitis and could be an etiologic cause of pancreatitis, similar to the other members of its group. Lessons: While the results of previous studies stated that there was no data to prove a causal relationship between dipeptidyl peptidase-4 inhibitors and pancreatitis, concerns regarding this subject have continued to arise. Therefore, new and comprehensive studies are needed to determine the long-term effects of dipeptidyl peptidase-4 inhibitors on type 2 diabetes mellitus patients and to shed light on the side effects of these medications.Öğe Lipoxin A4 Improves Ultrastructural View of Liver and Reduces Expression Levels of MKK4 and TGF-? During Thioacetamide (TAA) Induced Fibrosis(Wiley, 2017) Kurtoglu, Elcin; Kayhan, Basak; Gul, Mehmet; Kayhan, Burcak; Akdogan, Meral; Yilmaz, Sezai[No abstract available]Öğe Suttonella indologenes Peritonitis in a Patient Receiving Continuous Ambulatory Peritoneal Dialysis(Medknow Publications & Media Pvt Ltd, 2018) Sevencan, Nurhayat Ozkan; Bakirdogen, Serkan; Adar, Adem; Kayhan, BurcakSuttonella indologenes is a Gram-negative, aerobic coccobacillus of Cardiobacteriaceae family and its natural habitat is the mucous membranes of the upper respiratory system. The literature includes limited number of case reports concerning fatal endocarditis due to infection in the prosthetic heart valves caused by the aforementioned microorganism. However, there is no information on extracardiac involvement due to this microorganism. Here, we present a peritonitis case caused by Suttonella indologenes in a patient receiving continuous ambulatory peritoneal dialysis.Öğe An unusual cause of anaemia: Rapunzel syndrome, a case report(Pakistan Medical Assoc, 2020) Ozkan, Aysegul Ertinmaz; Danis, Nilay; Altundal, Mustafa; Sevencan, Nurhayat Ozkan; Karatas, Fatih; Kayhan, BurcakTrichobezoars present with stomach ache and with a mass in the stomach. It's common in the young and middle-aged women having psychiatric disorder, presenting with stomach ache and existence of mass in the stomach. Although it's one of the rare causes of anaemia it should be considered when dealing with cases of chronic and unresponsive anaemia.Öğe An unusual location of squamous cell carcinoma and a rare cutaneous infection caused by serratia marcescens on the tumoral tissue A case report(Lippincott Williams & Wilkins, 2018) Sevencan, Nurhayat Ozkan; Cakmakliogullari, Elcin Kal; Ozkan, Aysegul Ertinmaz; Kayhan, BurcakRationale: Serratia marcescens (S. marcescens) is an opportunistic pathogen of the Enterobacteriaceae family. Although S. marcescens is known to cause sepsis, meningitis, endocarditis, urinary system and ocular infections, skin infections are sporadic. Squamous cell carcinoma (SCC) is the most aggressive skin cancer type that is often located in the head and neck region, and rarely in the scalp tissue. Patient concerns: An 89-years-old male patient was diagnosed with SCC three years ago. The frontal region of the skull showed an ulcerated tumor, irregular borders, and exophytic growth pattern. The destruction of the frontal bone made the vibrating brain tissue visible, and the lower part had haemopurulent flow. Diagnoses: Gram staining showed the proliferation of gram (-) bacilli. Bacteria were identified as non-pigmented S. marcessens in the wound culture. To the best of our knowledge, there have not been any cases reported with S. marcescens causing cutaneous infections on SCC. Therefore, our report is the first case in the literature. Interventions: According to the culture antibiogram, S. marcescens was ciprofloxacin sensitive. Consequently, 1000mg/day ciprofloxacin was initiated for 14 days. Outcomes: Purulent exudate in skin cancers may be caused by the nature of carcinoma tissue as well as the colonization of opportunistic pathogen microorganisms as seen in our patient. Lessons: Examination of the wound cultures and elimination of infections are critical in these cases.
