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    Estimation of Indian and Turkish Hexaploid Wheat Population Structure Employing Molecular Markers
    (Academic Press, 2015) Pandey, A.; Khan, M.K.; Thomas, G.; Hakki, E.E.; Kayis, S.A.; Hamurcu, M.; Gezgin, S.
    Bread wheat (Triticum aestivum) is the most commonly grown crop due to its adaptation in a wide range of ecogeographical conditions and providing enhanced food assurance to the modern world. A diverse and rich collection is the foundation of each successful wheat improvement program. Therefore, major efforts are in progress worldwide to boost wheat production by broadening genetic diversity. Accepting this issue as a target, present study gives an overview of the major progress in the diversity and population evaluation of Indian and Turkish hexaploid wheat employing ISSR and RAPD primers. Various statistical analyses were employed for determining the hexaploid wheat population structure of India and Turkey. Results of dendrogram, scatterplots, Analysis of Molecular Variance (AMOVA) and population structure analysis were found in accordance with each other. All the experimental genotypes were clustered in two main groups, one group containing Indian varieties and another group containing both Indian and Turkish varieties reflecting the direct or indirect interbreeding among the populations of the two countries. Utilizing the genetic association of Indian and Turkish hexaploid wheat population, based on genetic distance estimated in the study, researchers worldwide may include Indian and Turkish hexaploid varieties in the wheat improvement programs and can evade the likelihood of selected germplasm becoming hereditarily consistent. © 2015, Notulae Botanicae Horti Agrobotanici Cluj-Napoca. All Rights Reserved.
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    Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial
    (Springer London, 2016) Koçak, E.; Saglam, M.; Kayis, S.A.; Dündar, N.; Kebapçilar, L.; G.Loos, B.; Hakki, S.S.
    In order to evaluate whether nonsurgical periodontal treatment with/without diode laser (DL) decontamination improves clinical parameters, the levels of IL-1?, IL-6, IL-8, intercellular adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) in gingival crevicular fluid and metabolic control (HbA1c) in chronic periodontitis (CP) patients with diabetes mellitus type 2 (DM2). Sixty patients with DM2 and CP were randomly assigned into two groups to receive scaling and root planing (SRP, n = 30) or SRP followed by diode laser application (SRP + DL, n = 30). Clinical periodontal and gingival crevicular fluid (GCF) parameters were assessed at baseline, 1, and 3 months after periodontal treatment. HbA1c levels were evaluated at baseline and 3 months post-therapy. Total amounts of cytokines and molecules were analyzed by ELISA. Nonsurgical periodontal treatment with/without DL appeared to improve clinical, biochemical parameters, and glycemic control in DM2 patients (BMI < 25 kg/m2) with CP. The SRP + DL group provided better reductions in probing depth (PD) and clinical attachment level (CAL) parameters compared to the SRP group (P < 0.05). Significant reductions were found in the total amounts of GCF levels of IL-1, IL-6, IL-8, ICAM, and VCAM after treatment (P < 0.05). HbA1c levels decreased significantly at 3 months after treatment (P < 0.05). SRP + DL reduced HbA1c levels more significantly compared to SRP alone (0.41 vs. 0.22 %, P < 0.05). SRP, especially in combination with DL, shows improvement of glycemic control for DM2 patients with CP. © 2016, Springer-Verlag London.
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    Selection of reliable reference genes for qRT-PCR analysis on head and neck squamous cell carcinomas
    (Scientific Publishers of India, 2017) Yigin, A.K.; Cora, T.; Acar, H.; Kurar, E.; Kayis, S.A.; Colpan, B.; Ozturk, K.
    The choice of reliable reference genes as an internal control is inevitable to obtain accurate results. Here we present an assessment of 7 reference genes (18S rRNA, 28S rRNA, ACTB, GAPDH, TUBA1, YWHAZ, and SDHA) to normalize gene expression data in Head and Neck Squamous Cell Carcinomas (HNSCCs). We attempted to determine a reliable set of reference genes to use in the normalization of gene expression data in Head and Neck Squamous Cell Carcinomas (HNSCCs) and normal mucosal tissues. Malignant and non-malignant tissue samples were collected from 12 patients with primary untreated HNSCC. geNorm and NormFinder software packages were used for data evaluations. Results obtained by geNorm indicated that average expression stability values (M) of all candidates genes were smaller than 1.5 (accepted M value for geNorm), showing that all the evaluated genes can be employed as HKGs, although GAPDH and ACTB were reported to be the most stable. Similarly, NormFinder results were in agreement with geNorm’s results. GAPDH and ACTB are considered to be most suitable reference genes to evaluate novel gene expression in the tissues several of HNSCCs. © 2017, Scientific Publishers of India. All rights reserved.
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    Wet cupping therapy improves health related quality of life: A self-controlled interventional study
    (Ankara Yildirim Beyazit University, 2019) Ersoy, S.; Inci, H.; Sunay, D.; Kayis, S.A.; Engin, V.S.; Benli, A.R.
    Objectives: Wet cupping therapy is an ancient treatment method which has been an integral part of Traditional Anatolian Medicine. In the current study we aimed to assess the efficacy of wet cupping therapy on health-related quality of life in healthy volunteers. Materials and Methods: This was a single arm pre-test and post-test interventional study conducted in Traditional and Complementary Medicine Clinic of Karabuk Education and Research Hospital between August 1, 2017 and August 1, 2018. Fifty-three healthy volunteers were enrolled in the study. They received three wet cupping therapy sessions once every month for three months (On 0, 30, and 60 days). WHOQOL-BREF-TR questionnaire was applied to all participants both before the sessions and after the third one. Wilcoxon signed rank test was employed to compare pre and post test scores. A p value <0.05 assumed to be statistically significant. All analyzes were carried out using Minitab 17 Statistical Software. Results: The study sample consisted of 26 female and 27 male subjects. Mean age was 43.68 ± 9.41 years. It was found 46.34 ± 9.78 years for females and 40.63± 8.43 years for males. Initial WHOQOLBREF- TR scores regarding general health (p<0.001) and the four domains which were physical (p<0.001), psychological (p<0.001), social relations (p<0.001) and the environmental domain (p<0.005) showed significant improvements after three WCT sessions Conclusion: Our results suggest that quality of life may be improved in healthy adults by wet cupping therapy. © 2019 Ankara Yildirim Beyazit University. All rights reserved.