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    Effect of 0.12% Chlorhexidine Use for Oral Care on Ventilator-Associated Respiratory Infections: A Randomized Controlled Trial
    (Lippincott Williams & Wilkins, 2021) Kes, Duygu; Aydin Yildirim, Tugba; Kuru, Cuneyt; Pazarlioglu, Fatma; Ciftci, Taner; Ozdemir, Mehmet
    Background: Evidence suggests that the effect of 0.12% chlorhexidine (CHX) use for oral care on the development of ventilator-associated pneumonia (VAP) and ventilator-associated tracheobronchitis (VAT) is lacking. Evidence-based approaches to the prevention of VAP and VAT are of paramount importance for improving patients' outcomes. Objectives: This study aimed to (1) compare the effect of 0.12% CHX use for oral care on preventing VAP and VAT with the placebo group, as well as (2) compare its effect on oral health and prevention of oral microbial colonization with the placebo group. Methods: Prospective, single-blinded, randomized controlled trial performed in 2 intensive care units at a hospital. The sample comprised 57 mechanically ventilated adults randomly allocated to the 0.12% CHX group and the placebo group. Barnason's oral assessment guide was used to evaluate the oral health of both groups before oral care during the first 24 hr of tracheal intubation (Day 0) and at Day 2 and Day 3. Oropharyngeal secretion, endotracheal tube aspirate, and nonbronchoscopic bronchoalveolar lavage samples were collected on Day 0 and Day 3. Results: The rate of VAT development was not statistically different between the groups (p = .318). However, a significant difference existed in the rate of VAP development (p = .043). The frequency of oropharyngeal colonization significantly decreased in the 0.12% CHX group compared with the placebo group at Day 3 (p = .001). Conclusion: The use of 0.12% CHX for oral care could be effective for VAP prevention and reducing microbial colonization in mechanically ventilated patients.
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    Genotype Distribution of Hepatitis C Virus and Demographic Features of The Patients in The Province of Karabuk
    (Galenos Yayincilik, 2020) Kuru, Cuneyt; Hamidi, Aziz Ahmad
    Objectives: It was aimed to determine the distribution of hepatitis C virus (HCV) genotypes among patients who had HCV infection, and to identify the demographic characteristics of these patients. Materials and Methods: Adult patients who underwent HCV genotyping between January 2016 and December 2019 in the microbiological laboratory of our hospital were included in the research. The age and gender of the patients were investigated retrospectively from the hospital registry. Results: 63% of the 169 patients who were included in the study were female and the mean age was 63.4 +/- 16.1. It was found out that of the patients, 85.8% were with genotype 1b, 4.2% with genotype 1a and 0.62% with genotype 2, while 3% of them had genotype 3 and 11% of them had genotype 4. It was determined that the mean age (62.2 +/- 14.6) and rate of female gender of patients who had genotype 1 was significantly higher than other patients. Whereas genotype 1b did not decline over the years, a slight increase was determined in genotype 4. Conclusion: It was found out that genotype 1b, was to be the most frequent genotype. The fact that most of the patients were female as well as they were elderly is epidemiologically remarkable.