Yazar "Sahin, S." seçeneğine göre listele
Listeleniyor 1 - 9 / 9
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Assessment of pretreatment albumin-bilirubin grade in pancreatic cancer patients with liver metastasis(Zerbinis Publications, 2020) Sakin, A.; Sahin, S.; Sakin, A.; Atci, M.M.; Yasar, N.; Arici, S.; Geredeli, C.Purpose: This study aimed to assess the effect of pretreatment albumin-bilirubin (ALBI) score on treatment outcomes in pancreatic cancer (PC) patients with liver metastasis at the time of diagnosis treated with chemotherapy (CT) in the first-line setting. Methods: This was a retrospective study of 273 PC patients ?18 years of age who had liver metastasis at the time of diagnosis and received CT in the first-line. ALBI score was calculated through the following formula; [(log10 bilirubin (?mol/L)×0.66)+[albumin(g/l)×?0.0852]. Patients were stratified into 3 categories based on the ALBI score as follows; grade I:ALBI ?-2.60, grade II:-2.60-1.39. Results: A total of 273 patients, [180 (65.9%) men and 93 (34.1%) women], were evaluated. The median age was 60 years. ALBI grade was I in 45 (16.4%) patients, II in 156 (57.1%) patients, and III in 72 (26.5%) patients. Based on the ALBI grade, median progression-free survival (mPFS) was 9 months in grade I patients, 6 months in grade II patients, and 4 months in grade III patients (p=0.002), with median overall survival (mOS) durations of 12 months vs. 8 months vs. 5 months, respectively (p<0.001). Multivariate analysis showed that ALBI grade II (HR,1.543) or III (HR,2.260) negatively affected survival. Conclusion: A higher pretreatment ALBI grade is related to worse OS and PFS in PC patients with liver metastasis treated with a first-line CT, and therefore it can help predict the treatment outcomes in these patients. © 2020 Zerbinis Publications. All rights reserved.Öğe Effect of Aging Treatment on Surface Roughness, Mechanical Properties, and Fracture Behavior of 6XXX and 7XXX Aluminum Alloys(Springer, 2014) Sevim, I.; Sahin, S.; Cug, H.; Cevik, E.; Hayat, F.; Karali, M.The effect of aging treatment on the surface roughness and mechanical properties of AA6061 and AA7075 alloys was studied. Microhardness and tensile tests were used to investigae the mechanical properties. X-ray diffraction analysis was used to investigate the surface of the specimens. Furthermore, after tensile tests fractured surfaces were examined with scanning electron microscopy. An atomic force microscope was employed for analysis of the effect of aging treatment on surface roughness. Higher surface roughness with an increase in the volume fraction of the precipitate was revealed.Öğe Factors affecting survival in patients with isolated liver-metastatic colorectal cancer treated with local ablative or surgical treatments for liver metastasis(Zerbinis Publications, 2019) Sakin, A.; Sahin, S.; Atci, M.M.; Yasar, N.; Geredeli, C.; Aribal, S.; Alemdar, A.Purpose: Local treatments for isolated synchronous or metachronous liver metastases in colorectal cancer (CRC) have been shown to improve overall survival (OS). The aim of this study was to investigate the factors affecting OS in CRC patients with isolated liver metastasis in whom the primary tumor and corresponding liver metastasis were treated with curative intent using local ablative or surgical methods. Methods: A total of 47 CRC patients presenting with an initial or subsequent isolated liver metastasis, who were treated with local surgical or ablative treatment for liver metastasis with curative intent, were enrolled in this study between 2007 and 2017. The possible factors affecting OS were analyzed. Results: Out of the 47 patients, 35 (74.5%) were male. The median age was 61 (25-80) years. Thirty-four (72.3%) patients underwent liver metastasectomy, while 13 (27.7%) patients were treated with non-surgical local ablative therapies (NSLAT) for liver metastasis. Median OS (mOS) could not be reached in patients who underwent metastasectomy at the time of diagnosis compared to 55 months in those undergoing metastasectomy following a chemotherapy period (p=0.03). Patients treated with NSLAT had a mOS of 60 months compared to “not reached’’ in those who underwent liver metastasectomy (p=0.45). mOS was higher in patients with pT4 stage vs.Öğe High serum levels of IGF-I and IGFBP3 may increase comorbidity risk for asthmatic patients(Comenius Univ, 2017) Acat, M.; Erbay, Toru U.; Sahin, S.; Arik, O.; Ayada, C.OBJECTIVE: Asthma is known as a chronic inflammatory lung disease which has also systemic features. Insulin-like growth factor I (IGF-I) plays a role for asthma pathogenesis. Controversially, IGF-binding protein 3 (IGFBP3) blocks asthma development. That is why IGF-I and IGFBP3 are targeted for future therapeutic treatments of asthma. We aimed to investigate serum level of IGF-I and IGFBP3 in patients with asthma. This study was performed in 27 asthma and 23 healthy individuals. Serum levels of IGF-I and IGFBP3 were measured by human ELISA assay kits. Serum levels of IGF-I and IGFBP3 were significanlty higher in the asthma group than the control group. Significant negative correlation was found between IGF-I and asthma control test (ACT) puan, O-2 saturation, Forced Expiratory Volume in 1 second/ Forced Vital Capacity (FEV1/FVC), Forced Expiratory Flow 25 second/75 second (FEF2575) (%). Significant positive correlation was found between IGFBP3 and IGF-I, systolic blood pressure. Significant negative correlation was found between IGF-I and FEV1 (ml). RESULTS: Our results indicate that the serum levels of IGF-I and IGFBP3 are significanlty elevated in the asthma group. We assume that current treatment strategies are not really good enough for asthma. We suppose further strategies which are seeking to balance IGF-I and IGFBP3 should be developed for more effective and curative treatment of asthma (Tab. 2, Fig. 2, Ref. 22). Text in PDF www.elis.sk.Öğe The impact of primary tumor localization on survival and treatment outcomes in patients with metastatic colorectal cancer-a multicenter study(Zerbinis Publications, 2019) Sahin, S.; Karatas, F.Purpose: To investigate the effects of sidedness on survival and treatment outcomes in patients with metastatic colorectal cancer (mCRC), since the accumulated data have increasingly reported that patient with right-sided mCRC are found to be associated with worse overall survival (OS) and poor response to anti-epidermal growth factor receptor (anti-EGFR) agents. Methods: This was a multi-center retrospective analysis of 177 patients with mCRC, who were treated and followed between 2014 and 2018 in different parts of Turkey. Patients were divided into 2 groups according to the primary tumor localization as right or left colon cancer. Clinical and demographic characteristics, treatment outcomes, and survival were analyzed to determine whether there was any association with tumor localization. Results: There were 53 (30%) patients with mCRC in the right group and 124 (70%) in the left group, with no difference between the groups in terms of clinical and demographic characteristics. There was no difference in OS between the left and right side localization in any RAS-mutant mCRC patients (22.1 vs. 27.9 months, respectively, p=0.19), whereas patients with all RAS-wild type tumor in the right colon were associated with a worse OS than left-sided counterparts (19.4 vs 29.9 months, respectively, p=0.01). Multivariate analysis revealed that the right-sided tumor (HR, 1.74; 95% CI: 1.165-2.608; p=0.007), the presence of comorbid disease (HR, 1.58; 95% CI: 1.079-2.321, p=0.019), body mass index (BMI) <25 (HR, 1.61; 95% CI: 1.108-2.352, p=0.013), grade III tumor (HR, 1.65; 95% CI: 1.109-2.457, p=0.014), and being unable to metastasectomy (HR, 2.10; 95% CI: 1.235-3582, p=0.006) were found to be independent predictors of worse survival. Conclusion: While right side localization was an independent negative predictor of survival in patients with mCRC, tumor sidedness was not found to be associated with response to treatment. The worse OS in right localization may be due to the aggressive nature of right-sided colon tumors which show faster progression, since their response to treatment does not appear to be different. © 2019 Zerbinis Publications. All rights reserved.Öğe Mean platelet volume and platelet distribution width correlates with prognosis of early colon cancer(Zerbinis Publications, 2020) Sakin, A.; Sahin, S.; Sakin, A.; Karatas, F.; Samanci, N.S.; Yasar, N.; Arici, S.Purpose: Several platelet indices have been linked to prognosis of various cancers, including metastatic colorectal cancer. The aim of this study was to investigate the prognostic effect of mean platelet volume (MPV) and platelet distribution width (PDW) in early colon cancer (CC) patients. Methods: This retrospective study included early CC patients who were followed up and treated between 2005 and 2017. Relapse free survival (RFS) and overall survival (OS) were determined with respect to several demographic and clinical characteristics of patients, including MPV and PDW. The cut-off value was determined as >8.5 fL for MPV (sensitivity: 67.1%, specificity 54.5%) and ?16% for PDW (sensitivity: 66.7%, specificity: 60.0%). Results: The study included 394 patients, 53.3% of which were male. Stage I, II, and III patients constituted 8.9%, 46.4%, and 44.7% of the study population, respectively. Among all patients, RFS and OS were significantly longer in patients with MPV?8.5 fL and PDW>16 fL (p<0.001 and p=0.011 for MPV, respectively; and p<0.001 and p=0.026 for PDW, respectively). In patients with stage III disease, those with MPV?8.5 fL had significantly longer RFS and OS compared to those with MPV >8.5 fL (p<0.001 and p=0.001, respectively). On the other hand, those with PDW>16% had significantly longer RFS than that in those with PDW ?16 fL among stage III patients (p<0.001). In multivariate analysis, stage, perineural invasion, lymphovascular invasion, adjuvant treatment, CEA, CA19-9, PDW, and MPV were found the most significant factors affecting RFS. Conclusion: Our study suggests that elevated MPV and decreased PDW appear to be unfavorable prognostic factors in early CC, especially in patients with stage III disease. Considering the wide availability and accessibility of these indices, it is reasonable to designate further larger prospective studies to clarify and verify their potential roles in early CC. © This work by JBUON is licensed under a Creative Commons Attribution 4.0 International License.Öğe The physical and mechanical properties of alumina-based ultralow cement castable refractories(Elsevier Sci Ltd, 2012) Gungor, A.; Celikcioglu, O.; Sahin, S.In this study, the effects of the type of alumina on the physical, chemical and mechanical properties of the ultralow cement castable (ULCC) refractories were investigated. Brown fused alumina, tabular alumina and rotary bauxite-based ULCC refractories were prepared by mixing each type of alumina with silicon carbide, carbon, cement, metallic silicon and microsilica. The density, porosity and cold crushing strength (CCS) of the refractory castables were measured after drying at 110 degrees C for 24 h and firing at 1450 degrees C for 5 h. The slag penetration resistance of the refractory castables was determined using slag corrosion tests. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX) and X-ray diffractometry (XRD) were used to characterize the castables. It was found that all three refractory castables had strong slag penetration resistance and that the tabular alumina-based refractory castable had the largest specific cold crushing strength with an acceptable percent of porosity among the refractory castables. (C) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.Öğe Visfatin and ghrelin: Can they be forthcoming biomarkers or new drug targets for asthma?(E-Century Publishing Corporation, 2015) Toru, Ü.; Ayada, C.; Genç, O.; Sahin, S.; Arik, Ö.; Acat, M.; Bulut, I.Background & aim: Asthma represents chronic inflammation of the airways and is associated with bronchial hyperresponsiveness and reversible airway obstruction. A novel adipokine visfatin and an appetite-modulating hormone ghrelin play a role in several diseases related with inflammation. Although visfatin is a pro-inflammatory adipokine, ghrelin mainly exerts anti-inflammatory effects. However, very little is known about the role of visfatin and ghrelin in asthma. In the present study, we aimed to investigate the role of visfatin and ghrelin in asthma by evaluating their serum levels in asthmatic patients. Materials and methods: This study was performed on 27 asthma and 23 healthy controls. Blood samples were collected in tubes without EDTA. Serum levels of visfatin and ghrelin were measured by human ELISA assay kits. Statistical analyses were performed by SPSS 16.0 package program and differences were considered statistically significant at p < 0.05. Results: Serum levels of visfatin and ghrelin were significantly higher in asthma group (respectively; p = 0.001, p = 0.002). Conclusion: While visfatin has a pro-inflammatory role, ghrelin exerts an anti-inflammatory effect in asthma. Therefore, visfatin can be a forthcoming biomarker and ghrelin may be a new anti-inflammatory drug target to diagnose and treat asthmatic patients. © 2015, E-Century Publishing Corporation. All rights reserved.Öğe Which Came First Chicken Or Egg: Are Ghrelin And Visfatin Markers Or Results Of Asthma?(Amer Thoracic Soc, 2015) Toru, U.; Ayada, C.; Genc, O.; Sahin, S.; Arik, O.; Acat, M.[No abstract available]
