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    Dose-dependent effects of kefir on colitis induced by trinitrobenzene sulfonic acid in rats
    (Wiley, 2019) Sevencan, Nurhayat Ozkan; Isler, Mehmet; Kapucuoglu, Fatma Nilgun; Senol, Altug; Kayhan, Burcak; Kiztanir, Sefa; Kockar, Muhammed Cem
    Evidence suggests that gut microbiota dysbiosis plays a critical role in the initiation and promotion of inflammatory bowel disease (IBD). Kefir is a fermented dairy product including yeast and bacterial species. We aimed to investigate the effect of kefir on trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats using two different doses. Fifty-four Wistar rats were divided into six groups. For 14 days, the normal control and colitis control groups were given tap water, kefir10 control, kefir10 colitis, and kefir30 control, and the kefir30 colitis groups were given phosphate-buffered saline containing 10% or 30% kefir, respectively, instead of tap water. Colitis was induced by intracolonically administrating TNBS in the colitis control, kefir10 colitis, and kefir30 colitis groups. On the 14th day, the rats were sacrificed. The weights and lengths of the colons were measured and macroscopically evaluated, and the distal 10 cm segments were subjected to a histopathological examination. The incidence of bloody stool and diarrhea in the kefir10 colitis group was found to be less than the colitis control and kefir30 colitis groups. The colonic weight/length ratio in the kefir10 colitis group was lower than that in the colitis control and kefir30 colitis groups. We detected that the 10% kefir treatment reduced TNBS-induced macroscopic colonic damage, while it was exacerbated by the 30% kefir treatment. No significant difference was observed between the colitis groups in terms of microscopic colonic damage scoring. These results indicate that kefir, with a careful dose selection, may be a useful agent in the treatment of IBD.
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    Significance of C-reactive Protein in the Endoscopic Retrograd Cholangiopancreatography Related Pancreatitis
    (Derman Medical Publ, 2015) Akin, Mete; Kockar, Muhammed Cem; Aksakal, Gokhan; Senol, Altug
    Aim: Endoscopic retrograde cholangiopancreatography ( ERCP) may be related with complications such as pancreatitis. C-reactive protein (CRP) can be provides reliable informations about post-ERCP complications and their severity. In our study, the role of CRP levels in the follow-up post-ERCP pancreatitis was investigated. Material and Method: 476 patients, whom performed ERCP for different indications, were retrospectively evaluated. 136 patients with measurement of serum amylase, lipase and CRP levels before and 1224 hours after the procedure were included the study. Alterations of these parameters in complicated and uncomplicated patiens were investigated. The role of CRP in the follow-up and prediction of severity of pancreatitis was investigated in 22 complicated patients with measurement of serum amylase, lypase and CRP levels 36-48 hours after the procedure. Pancreatitis were classified as mild, moderate, or severe. Results: Post-ERCP pancreatitis occured in 23 (17%) patients ( 9 mild and 14 moderate pancreatitis). The mean CRP levels (mg/l) at 12 to 24 hours were 23,5 +/- 24,18 in uncomplicated patients, and 59,2 +/- 44,87 in patiens with pancreatitis (p<0,05). The mean CRP levels (mg/l) at 12 to 24 hours were 30,8 +/- 14,24 in mild pancreatitis and 77,5 +/- 48,66 in moderate pancreatitis (p<0,05). The levels, respectively, at 36 to 48 hours were 37,7 +/- 20,73 and 84,6 +/- 48,31 (p<0,05). In the ROC curve analysis, significant cut-off values of CRP levels at 12 to 24 and 36 to 48 hours were 41 mg/l and 45 mg/l, respectively. Discussion: The follow-up of serum CRP levels after ERCP is a useful method for predicting and determining of severity of post-ERCP pancreatitis.