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Öğe Comparison of the Fractional Exhaled Nitric Oxide Levels in Adolescents at Three Schools Located Three Different Distances from a Large Steel Mill(Hindawi Ltd, 2017) Acat, Murat; Aydemir, Yusuf; Yazjcj, Onur; Turgut, Mahmut; Cortuk, Mustafa; Cakar, Murat; Yasar, ZehraObjectives. Exposure to ambient metals and air pollutants in urban environments has been associated with impaired lung health and inflammation in the lungs. Fractional exhaled nitric oxide (FeNO) is a reliablemarker of airway inflammation. In this study, we aimed to compare the FeNO levels of three schools that have different distances from iron and steel industry zone for assessing the effects of heavy metals and air pollution on their respiratory health. Methods. Pulmonary function test and FeNO measurements were evaluated in 387 adolescents in three schools which have different distance from plant. Results. FeNO levels were significantly higher in School I (n = 142; 18.89 +/- 12.3ppb) and School II (n = 131; 17.68 +/- 7.7 ppb) than School III (n = 114; 4.28 +/- 3.9 ppb). Increased FeNO concentration was related to the distance of iron and steel industry zone in young adults. Conclusion. The FeNO concentrations in school children were inversely proportional to the distance from the steel mill. There are needed some studies that can evaluate the safe distance and legislation must consider these findings.Öğe Diagnosis of Pulmonary Hydatid Cyst by Bronchoscopy(Lippincott Williams & Wilkins, 2015) Yasar, Zehra; Acat, Murat; Turgut, Erhan; Onaran, Hilal; Dincer, Huseyin Erhan; Arda, Naciye; Cetinkaya, ErdoganHydatid cyst is a parasitic infestation caused by Echinococcus granulosus. Lungs are the second most common site of involvement after liver. The diagnosis of complicated pulmonary hydatid cysts may not be easy because hydatid cyst disease mimics tuberculosis, lung cancer, empyema, or abscess. Fiberoptic bronchoscopy can be a valuable tool in the diagnosis of the infestation by visualization of hydatid cyst membrane. Here, we report the case of a 33-year-old woman who presented with hemoptysis and chest discomfort and was diagnosed with a hydatid cyst by fiberoptic bronchoscopy.Öğe Evaluation of ACE2 and AT2R Polymorphisms in Patients with Asthma(Wiley-Blackwell, 2015) Ayada, Ceylan; Toru, Umran; Genc, Osman; Sahin, Server; Taskin, Emre; Yasar, Zehra; Bulut, Ismet[No abstract available]Öğe Evaluation of multidrug resistance-1 gene C > T polymorphism frequency in patients with asthma(Hospital Clinicas, Univ Sao Paulo, 2015) Toru, Umran; Ayada, Ceylan; Genc, Osman; Yasar, Zehra; Sahin, Server; Taskin, Emre; Bulut, IsmetOBJECTIVES: Asthma is a chronic inflammatory lung disease characterized by bronchial hyperresponsiveness and airflow obstruction. Genetic and oxidative stress factors, in addition to pulmonary and systemic inflammatory processes, play a pivotal role in the pathogenesis of asthma. The products of the multidrug resistance-1 gene protect lung tissue from oxidative stress. Here, we aimed to evaluate the association between the multidrug resistance-1 gene C>T polymorphism and asthma with regard to oxidative stress-related parameters of asthmatic patients. METHODS: Forty-five patients with asthma and 27 healthy age-matched controls were included in this study. Blood samples were collected in tubes with ethylenediaminetetraacetic acid. DNA was extracted from the blood samples. The multidrug resistance-1 gene polymorphism was detected by polymerase chain reaction and a subsequent enzyme digestion technique. The serum levels of total oxidant status and total antioxidant status were determined by the colorimetric measurement method. RESULTS: The heterozygous polymorphic genotype was the most frequent in both groups. A significant difference in the multidrug resistance-1 genotype frequencies between groups indicated an association of asthma with the TT genotype. A significant difference between groups was found for wild type homozygous participants and carriers of polymorphic allele participants. The frequency of the T allele was significantly higher in asthmatic patients. The increase in the oxidative stress index parameter was significant in the asthma group compared with the control group. CONCLUSIONS: The multidrug resistance-1 gene C/T polymorphism may be an underlying genetic risk factor for the development of asthma via oxidant-antioxidant imbalance, leading to increased oxidative stress.Öğe Primary pulmonary lymphoma: four different and unusual radiologic and clinical manifestations(Taylor & Francis Ltd, 2017) Tanriverdi, Elif; Acat, Murat; Ozgul, Guler; Abbasli, Kenan; Gul, Sule; Yasar, Zehra; Cortuk, Mustafa[No abstract available]Öğe Retrospective review of epidemic viral pneumonia cases in Turkey: A multicenter study(Spandidos Publ Ltd, 2017) Cortuk, Mustafa; Acat, Murat; Yazici, Onur; Yasar, Zehra; Kiraz, Kemal; Ataman, Sena Yapicioglu; Tanriverdi, ElifInfluenza A (H1N1) caused its first pandemic in 2009 in USA and Mexico. Since then, clinicians have exercised great care in order to make an early diagnosis of viral pneumonias. This is due in part to pandemic influenza A infection having greater impact on populations <65 years old than other viral strains, including seasonal influenza. Chest radiographies of those affected displayed a rapid progression of patchy infiltrates, and a large proportion of individuals required admission to intensive care units (ICU). Despite efforts, patients infected with the virus had a high mortality rate. The present multicenter study aimed to retrospectively evaluate the clinical, demographic and prognostic characteristics of patients diagnosed with epidemic viral pneumonia in Turkey. A total of 92 patients were included in the study. The Student's t-test and Chi-square tests were performed to analyze quantitative data, assuming a normal distribution, and to analyze qualitative data, respectively. Stepwise logistic regression was used to evaluate the effects of demographic variables and laboratory values on the virus mortality rate. The male/female ratio was 42/50 and the mean age was 48.74 +/- 16.65 years. A total of 69 (75%) patients were unvaccinated against influenza. The most common symptoms were cough (87%) and fever (63%). Chest computed tomography showed peripheral patchy areas of the lungs of ground glass density in 38 patients (41.3%). A total of 22 (59.4%) patients had H1N1, 5 (12.5%) patients had influenza B, and 38 (41.3%) patients met the criteria for admission to the ICU. Of these patients, 20 (52.63%) were monitored with a mechanical ventilator, with a noninvasive ventilator being adequate for 10 (26.32%) of patients. The length of stay in the ICU was 6.45 +/- 5.97 days and the duration of mechanical ventilation was 5.06 +/- 4.69 days. A total of 12 (13.04%) patients in the ICU succumbed. Logistic regression analysis revealed that among the parameters possibly associated with mortality, being an active smoker increased the risk of mortality 7.08-fold compared to other groups (P=0.005). In conclusion, viral pneumonia remains a significant health problem during the winter period. Considering the high number of ICU admissions and high rate of mortality for patients in the present study, earlier initiation of antiviral therapy is necessary. Active smoking increased mortality in viral pneumonia.Öğe Smoking prevalence, associated attitudes and comparison of negative automatic thoughts among high school students in Turkey(European Respiratory Soc Journals Ltd, 2015) Acat, Murat; Memis, Cagdas Oyku; Turan, Muhammet Kamil; Benli, Ali Ramazan; Taskin, Emre; Yasar, Zehra; Memis, Seda Derici[No abstract available]Öğe Tracheobronchial Amyloidosis Mimicking Tracheal Tumor(Hindawi Ltd, 2016) Tanriverdi, Elif; Ozgul, Mehmet Akif; Uzun, Oguz; Gul, Sule; Cortuk, Mustafa; Yasar, Zehra; Acat, MuratTracheobronchial amyloidosis is a rare presentation and accounts for about 1% of benign tumors in this area. The diagnosis of disease is delayed due to nonspecific pulmonary symptoms. Therapeutic approaches are required to control progressive pulmonary symptoms for most of the patients. Herein, we report a case of a 68-year-old man admitted with progressive dyspnea to our institution for further evaluation and management. He was initially diagnosed with and underwent management for bronchial asthma for two years but had persistent symptoms despite optimal medical therapy. Pulmonary computed tomography scan revealed severe endotracheal stenosis. Bronchoscopy was performed and showed endotracheal mass obstructing 70% of the distal trachea and mimicking a neoplastic lesion. The mass was successfully resected by mechanical resection, argon plasma coagulation (APC), and Nd-YAG laser during rigid bronchoscopy. Biopsy materials showed deposits of amorphous material by hematoxylin and eosin staining and these deposits were selectively stained with Congo Red. Although this is a rare clinical condition, this case indicated that carrying out a bronchoscopy in any patient complaining of atypical bronchial symptoms or with uncontrolled asthma is very important.Öğe Treatment of persistent air leak with endobronchial valves: a case report(Turkish Assoc Tuberculosis & Thorax, 2015) Cetinkaya, Erdogan; Yasar, Zehra; Acat, Murat[No abstract available]
