Detection of the differences in the apparent diffusion coefficient values in different histopathological types of malignant breast lesions and comparison of cellular region/ stroma ratio and histopathological results

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dc.contributor.authorKöremezli Keskin, Nevin
dc.contributor.authorBalcı, Pınar
dc.contributor.authorBasara Akın, Işıl
dc.contributor.authorYavuz Gürkan, Esra
dc.contributor.authorSevınç, Ali İbrahim
dc.contributor.authorDurak, Merih Güray
dc.contributor.authorErsen Danyeli, Ayça
dc.date.accessioned2024-09-29T16:31:08Z
dc.date.available2024-09-29T16:31:08Z
dc.date.issued2018
dc.departmentKarabük Üniversitesien_US
dc.description.abstractBackground/aim: This study aimed to compare the apparent diffusion coefficient (ADC) values of malignant breast lesions with differenthistopathological types on diffusion-weighted imaging (DWI) and the cellular region/stroma (CR/S) ratio and histopathological results.Materials and methods: Breast diffusion-weighted magnetic resonance findings of 59 patients were retrospectively analyzed formalignant breast lesions. The CR/S ratio was calculated using breast wide-excisional biopsy or mastectomy specimens.Results: Receiver operating characteristic analysis was performed for malignant lesions and subtypes. An ADC threshold of 1.260 ×10–3 mm2/s was set to detect invasive ductal carcinoma with 80.8% sensitivity and 81.4% specificity. An ADC threshold of 1.391 × 10–3mm2/s was set to detect invasive lobular carcinoma lesions with 88.2% sensitivity and 79.5% specificity. The ADC value for lesions withlow CR/S ratio (n = 21) was 1.135 ± 0.429 × 10–3 mm2/s and it was 1.155 ± 0.429 × 10–3 mm2/s in the high CR/S ratio group (n = 18).Conclusion: ADC value calculation does not seem to be used as an alternative for histopathological detection, which is the gold standardfor the differentiation of subtypes of malignant breast cancer. In addition, since there is a positive correlation between CR/S ratio andADC values, it may be a strong marker to evaluate the stromal component of lesions.en_US
dc.identifier.doi10.3906/sag-1801-89
dc.identifier.endpage825en_US
dc.identifier.issn1300-0144
dc.identifier.issue4en_US
dc.identifier.startpage817en_US
dc.identifier.trdizinid299297en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1801-89
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/299297
dc.identifier.urihttps://hdl.handle.net/20.500.14619/11181
dc.identifier.volume48en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleDetection of the differences in the apparent diffusion coefficient values in different histopathological types of malignant breast lesions and comparison of cellular region/ stroma ratio and histopathological resultsen_US
dc.typeArticleen_US

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