Evaluation of Dynamic Thiol/Disulfide Homeostasis in Patients with Non-Muscle Invasive Bladder Tumor

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dc.authoridAYKAC, AYKUT/0000-0001-7078-0135
dc.authoridBURLUKKARA, SALIH/0000-0002-2149-0163
dc.contributor.authorBurlukkara, Salih
dc.contributor.authorBaran, Ozer
dc.contributor.authorAykac, Aykut
dc.contributor.authorSunay, M. Mehmet
dc.date.accessioned2024-09-29T16:08:32Z
dc.date.available2024-09-29T16:08:32Z
dc.date.issued2023
dc.departmentKarabük Üniversitesien_US
dc.description.abstractObjective: To evaluate the thiol-disulfide homeostasis in patients with a diagnosis of non-muscle invasive bladder tumor (NMIBC), which is a new oxidative stress marker, and to investigate the relationship between the development of NMIBC and native thiol, total thiol, and dynamic disulfide values. Materials and Methods: Fifty-three patients who were operated for bladder tumor in Karabuk University Karabuk Training and Research Hospital, Clinic of Urology between February and November 2020 and diagnosed with NMIBC in the pathological examination and 60 healthy volunteers were included in the study. Plasma native thiol, total thiol and disulfide levels of these two groups were measured and compared. Results: There was a statistically significant difference between the two groups in terms of native thiol, total thiol and disulfide values. In the subgroup analysis in those diagnosed with NMIBC, native thiol values were found to be 255,870 mu mol/L in the low grade patient group and 169,420 mu mol/L in the high grade patient group. This difference was statistically significant. Conclusion: The thiol disulfide homeostasis shifted to the disulfide side in the NMIBC group. It was determined that an increase in serum disulfide level and a decrease in native thiol level may have diagnostic value in predicting NMIBC. In addition, in the group diagnosed with NMIBC, there was a significant decrease in native thiol values as the pathological grade increased. This was interpreted as a shift of the equilibrium towards the oxidant side as the tumor showed an aggressive course.en_US
dc.identifier.doi10.4274/jus.galenos.2022.2022.0033
dc.identifier.endpage35en_US
dc.identifier.issn2148-9580
dc.identifier.issue1en_US
dc.identifier.startpage31en_US
dc.identifier.trdizinid1168246en_US
dc.identifier.urihttps://doi.org/10.4274/jus.galenos.2022.2022.0033
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1168246
dc.identifier.urihttps://hdl.handle.net/20.500.14619/7605
dc.identifier.volume10en_US
dc.identifier.wosWOS:000994428100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal of Urological Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBladder canceren_US
dc.subjectthiolen_US
dc.subjectdisulfideen_US
dc.titleEvaluation of Dynamic Thiol/Disulfide Homeostasis in Patients with Non-Muscle Invasive Bladder Tumoren_US
dc.typeArticleen_US

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